2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. PARP

PARP

poly ADP ribose polymerase

PARP

Related Products

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PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. The PARP family comprises 17 members. They have all very different structures and functions in the cell. PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2) have a confirmed PARP activity. Others include PARP3, PARP6, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. PARP is found in the cell’s nucleus. The main role is to detect and signal single-strand DNA breaks (SSB) to the enzymatic machinery involved in the SSB repair.

PARP Isoform Specific Products:

PARP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W424851
    DPQ hydrochloride
    		Inhibitor
    DPQ hydrochloride is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD+/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ hydrochloride inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ hydrochloride can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases.
    DPQ hydrochloride
  • HY-131688R
    2-Chlorohexadecanoic acid (Standard)
    		Inhibitor
    Neomycin (sulfate) (Standard) is the analytical standard of Neomycin (sulfate). This product is intended for research and analytical applications. Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis.
    2-Chlorohexadecanoic acid (Standard)
  • HY-RS10063
    PARP3 Human Pre-designed siRNA Set A
    		Inhibitor

    PARP3 Human Pre-designed siRNA Set A contains three designed siRNAs for PARP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PARP3 Human Pre-designed siRNA Set A
    PARP3 Human Pre-designed siRNA Set A
  • HY-150613
    PARP1/BRD4-IN-2
    		Inhibitor
    PARP1/BRD4-IN-2 is a potent and selective PARP1 and BRD4 inhibitor with IC50 values of 197 nM and 238 nM, respectively. PARP1/BRD4-IN-2 inhibits DNA damage repair, arrests G0/G1 transition and induces apoptosis. PARP1/BRD4-IN-2 has anti-tumor activity in MDA-MB-468 xenograft mouse model. PARP1/BRD4-IN-2 can be used for researching triple-negative breast cancer (TNBC).
    PARP1/BRD4-IN-2
  • HY-173349
    TDI-012804
    		Inhibitor
    TDI-012804 is a TNKS2 inhibitor that selectively inhibits intracellular endogenous TNKS2 protein. TDI-012804 increases the expression of AXIN1 protein in cells that are heterozygous (Tnks1HET) and completely knocks out (Tnks1KO) for TNKS1. TDI-012804 inhibits the proliferation of ApcQ1405X/Tnks1KO organoids (EC50 of 59.1 nM) and is selectively toxic to Tnks1KO AKP-G12D and AKP-G13D organoids.
    TDI-012804
  • HY-RS14547
    Tiparp Mouse Pre-designed siRNA Set A
    		Inhibitor

    Tiparp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tiparp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Tiparp Mouse Pre-designed siRNA Set A
    Tiparp Mouse Pre-designed siRNA Set A
  • HY-168724
    Thalidomide-piperidine-C-Pip-C2-Pip-C2-OH
    		Degrader
    Thalidomide-piperidine-C-Pip-C2-Pip-C2-OH (Compound C6) is a conjugate of the linker and E3 ligase ligand, that can be used in synthesis of PROTAC PARP1 degrader-30 (HY-168722).
    Thalidomide-piperidine-C-Pip-C2-Pip-C2-OH
  • HY-155766
    PARP1-IN-14
    		Inhibitor
    PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1−/−) and Capan-1 (BRCA2−/−) cells with IC50 values below 0.3 nM.
    PARP1-IN-14
  • HY-173259
    PARP7-IN-23
    		Inhibitor
    PARP7-IN-23 (compound 56) is a potent PARP7 inhibitor with an EC50 of 0.915 nM for pSTAT1 in NCI-H1373 cells. PARP7-IN-23 has the potential for cancer research.
    PARP7-IN-23
  • HY-152198
    Tankyrase-IN-4
    		Inhibitor
    Tankyrase-IN-4 is a tankyrase 1 (TNKS1) inhibitor with an IC50 value of 0.8 nM. Tankyrase-IN-4 can be used for the research of cancer.
    Tankyrase-IN-4
  • HY-158680
    PARP1-IN-21
    		Inhibitor
    PARP1-IN-21 (example 16) is a potent inhibitor of PARP1, with the IC50 of ＜ 10 nM.
    PARP1-IN-21
  • HY-RS10066
    PARP4 Human Pre-designed siRNA Set A
    		Inhibitor

    PARP4 Human Pre-designed siRNA Set A contains three designed siRNAs for PARP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PARP4 Human Pre-designed siRNA Set A
    PARP4 Human Pre-designed siRNA Set A
  • HY-147514
    Anticancer agent 64
    		Inhibitor
    Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization.
    Anticancer agent 64
  • HY-N15380
    4,4′-Secalonic acid D
    		Inhibitor
    4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the caspase-3/GSDME pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity.
    4,4′-Secalonic acid D
  • HY-145471A
    KSQ-4279 (gentisate)
    		Inhibitor
    KSQ-4279 (gentisate) (Compound Formula I) is a potent USP1 inhibitor and a selective PARP1 inhibitor. KSQ-4279 (gentisate) is promising for research of cancers.
    KSQ-4279 (gentisate)
  • HY-162643
    Antitumor agent-169
    		Inhibitor
    Antitumor agent-169 (Compound B3) is a dual inhibitor PD-1/PD-L1 interaction and PARP7, with IC50s of 0.426 μM and 2.50 nM. Antitumor agent-169 exhibits an affinity to human PD-L1, with Ki of 20.2 nM. Antitumor agent-169 restores the T cell function, increases IFN-γ secretion. Antitumor agent-169 inhibits cell viability of MDA-MB-231 and Jurkat T, exhibits antitumor efficacy against melanoma in mouse model and good pharmacokinetic characteristics.
    Antitumor agent-169
  • HY-12601
    TNKS 22
    		Inhibitor
    TNKS 22 (compound 22) is an orally active and selective tankyrase inhibitor. TNKS 22 inhibits TNKS1 and TNKS2 with IC50s of 0.1 and 4.1 nM, respectively.
    TNKS 22
  • HY-15050
    KCL-440
    		Inhibitor
    KCL-440 is a CNS-penetrated PARP inhibitor, with an IC50 of 68 nM. KCL-440 has strong inhibition of PARP-1.
    KCL-440
  • HY-D1188
    PARP7-probe-1
    PARP7-probe-1 is a chemiluminescent labeled PARP7 probe. PARP7-probe-1 is a biotinylated probe binding to the PARP7 active site. PARP7-probe-1 can be used for the research of PARP7 function.
    PARP7-probe-1
  • HY-151624
    PARP-2-IN-2
    		Inhibitor
    PARP-2-IN-2 (compound 27) is a PARP 2 inhibitor with an IC50 value of 0.057 μM. PARP-2-IN-2 induces cell cycle arrest and apoptosis of MCF-7 breast cancer cells. PARP-2-IN-2 can be used for the research of cancer.
    PARP-2-IN-2
Cat. No. Product Name / Synonyms Application Reactivity
PARP Isoform Comparison

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