2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Microtubule/Tubulin

Microtubule/Tubulin

Microtubule/Tubulin

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Microtubules are a component of the cytoskeleton, found throughout the cytoplasm. These tubular polymers of tubulin can grow as long as 50 micrometres, with an average length of 25 µm, and are highly dynamic. The outer diameter of a microtubule is about 24 nm while the inner diameter is about 12 nm. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. Tubulin is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family which is present only in kinetoplastid protozoa. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-17435R
    4'-Demethylepipodophyllotoxin (Standard)
    		Inhibitor
    4'-Demethylepipodophyllotoxin (Standard) is the analytical standard of 4'-Demethylepipodophyllotoxin. This product is intended for research and analytical applications. 4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.
    4'-Demethylepipodophyllotoxin (Standard)
  • HY-160992
    Vinepidine sulfate
    		Inhibitor
    Vinepidine (LY-119863) sulfate is a derivative of vincristine (HY-N0488). Vinepidine sulfate has antitumor activity.
    Vinepidine sulfate
  • HY-Z8644
    N-Deacetyl-N-formylcolchicine
    		Inhibitor
    N-Deacetyl-N-formylcolchicine (N-Formyl-N-deacetylcolchicine, Compound 11) is a selective inhibitor targeting the colchicine-binding site of tubulin. N-Deacetyl-N-formylcolchicine shows antiproliferative activity against various cancer cell lines with IC50 values of 32.61-100.28 nM. N-Deacetyl-N-formylcolchicine inhibits microtubule polymerization to block cell division, induces cancer cell apoptosis and suppresses migration. N-Deacetyl-N-formylcolchicine is promising for research of cancers such as lung cancer and various solid tumors.
    N-Deacetyl-N-formylcolchicine
  • HY-119427
    Anti-melanoma agent 3
    		Inhibitor
    Anti-melanoma agent 3 (compound 5cb) is a 2-aryl-4-benzoyl-imidazole (ABI) derivative and an inhibitor of melanoma xenogeneic tumors. Anti-melanoma agent 3 exerts anticancer activity by interacting with the colchicine binding site to inhibit tubulin polymerization.
    Anti-melanoma agent 3
  • HY-115958
    Tubulin inhibitor 20
    		Inhibitor
    Tubulin inhibitor 20 (compound 1) is a potent inhibitor of tubulin. Tubulin inhibitor 20 has the potential for the research of cancer diseases.
    Tubulin inhibitor 20
  • HY-149363
    Tubulin polymerization-IN-43
    		Inhibitor 99.60%
    Tubulin polymerization-IN-43 (compound 15h) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-43 disrupts cellular microtubule networks by targeting the Colchicine (HY-16569) site, and promots cell cycle arrest of leukemia cells at G2/M phase and cell apoptosis, as well as inhibiting angiogenesis.
    Tubulin polymerization-IN-43
  • HY-13589A
    Cemadotin hydrochloride
    		Inhibitor
    Cemadotin (LU103793) hydrochloride is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin hydrochloride blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin hydrochloride can be used to research anticancer.
    Cemadotin hydrochloride
  • HY-157529
    IR820-PTX
    IR820-PTX, an IR-820 (HY-136886)-Paclitaxel (HY-B0015) conjugate, is an amphipathic small molecule prodrug. IR820-PTX effectively inhibits tumor growth via combined photothermal therapy (PTT) and chemotherapy.
    IR820-PTX
  • HY-145868
    Tubulin polymerization-IN-3
    		Inhibitor
    Tubulin polymerization-IN-3 (compound 4c) is a potent tubulin polymerization inhibitor, with an IC50 of 3.84 µM. Tubulin polymerization-IN-3 can induce apoptosis in colon cancer cells.
    Tubulin polymerization-IN-3
  • HY-156958
    S-72
    		Inhibitor
    S-72 inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing STAT3 signaling.
    S-72
  • HY-150595
    HDAC6-IN-10
    		Inhibitor
    HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC50 of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells.
    HDAC6-IN-10
  • HY-164272
    2'-O-TBDMS-Paclitaxel
    2'-O-TBDMS-Paclitaxel is a paclitaxel (HY-B0015) derivative which 2'-OH group is protected as a tert-butyldimethylsilyl (TBDMS) ether.
    2'-O-TBDMS-Paclitaxel
  • HY-P990894
    Anti-DM1 antibody(14E3) (Rabbit mAb)
    		Control
    Anti-DM1 antibody (14E3) (Rabbit mAb) is a rabbit-derived IgG type antibody, targeting to DM1 (HY-19792). Anti-DM1 antibody (14E3) (Rabbit mAb) can be used for ELISA experiment in species independent background.
    Anti-DM1 antibody(14E3) (Rabbit mAb)
  • HY-D0958R
    Methylene blue hydrate (Standard)
    		Inhibitor
    Methylene blue (hydrate) (Standard) is the analytical standard of Methylene blue (hydrate). This product is intended for research and analytical applications. Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation.
    Methylene blue hydrate (Standard)
  • HY-111555
    AmPEG6C2-Aur0131
    		Inhibitor
    AmPEG6C2-Aur0131 is a agent-linker conjugate for ADC (anti-CXCR4 ADC) with potent antitumor activity by using Aur0131 (an auristatin microtubule inhibitor), linked via the non-cleavable linker AmPEG6C2.
    AmPEG6C2-Aur0131
  • HY-146114
    Antitumor agent-67
    		Inhibitor
    Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity.
    Antitumor agent-67
  • HY-175292
    EGFR WT/T790M-IN-3
    		Inhibitor
    EGFR WT/T790M-IN-3 is an irreversible covalent EGFRWT and EGFRT790M inhibitor with IC50s value of 28.1 and 24.6 nM. EGFR WT/T790M-IN-3 hampers tubulin polymerization through IC50 value of 5.1 μM. EGFR WT/T790M-IN-3 shows significant anti-proliferative effects on HCT116 and T47D cells, with IC50 values of 3.12 and 4.12 μM, respectively. EGFR WT/T790M-IN-3 can be used for the study of cancers such as non-small cell lung cancer, colon cancer and breast cancer.
    EGFR WT/T790M-IN-3
  • HY-168721
    Tubulin inhibitor 48
    Tubulin inhibitor 48 (compound 16) is an anti-cancer agent targeting tubulin. Tubulin inhibitor 48 has an IC50 of 0.1 and 0.07 μM for LN-229 and Capan-1 cell, respectively.
    Tubulin inhibitor 48
  • HY-113722
    DAT1
    DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization.
    DAT1
  • HY-119361
    (Rac)-Deox B 7,4
    		Inhibitor
    (Rac)-Deox B 7,4, a homoisoflavanoid compound, inhibits microtubule polymerization via binding near the colchicine site and promote reversible G2 arrest. (Rac)-Deox B 7,4 possesses nanomolar anti-leukemic activity.
    (Rac)-Deox B 7,4
Cat. No. Product Name / Synonyms Application Reactivity