2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112540AR
    Acetoacetic acid lithium (Standard)
    Acetoacetic acid (lithium) (Standard) is the analytical standard of Acetoacetic acid (lithium). This product is intended for research and analytical applications. Acetoacetic acid lithium is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid lithium induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid lithium can be used to study metabolic diseases.
    Acetoacetic acid lithium (Standard)
  • HY-I0352R
    Epiandrosterone (Standard)
    Epiandrosterone (Standard) is the analytical standard of Epiandrosterone. This product is intended for research and analytical applications. Epiandrosterone is a steroid hormone. Epiandrosterone activates BKCa. Epiandrosterone inhibits glucose transport and insulin release. Epiandrosterone has weak androgenic activity.
    Epiandrosterone (Standard)
  • HY-110382S
    13C20,15N10-Cyclic di-GMP sodium
    13C20,15N10-Cyclic di-GMP (13C20,15N10-c-di-GMP) is 13C and 15N labeled Cyclic-di-GMP (disodium). Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research.
    <sup>13</sup>C<sub>20</sub>,<sup>15</sup>N<sub>10</sub>-Cyclic di-GMP sodium
  • HY-N13714
    O-Methylcassythine
    O-Methylcassythine is an aporphine alkaloid, that can be isolated from Cassytha filiformis. O-Methylcassythine exhibits vasodilator activity.
    O-Methylcassythine
  • HY-B0275BR
    Oxytetracycline dihydrate (Standard)
    Oxytetracycline (dihydrate) (Standard) is the analytical standard of Oxytetracycline (dihydrate). This product is intended for research and analytical applications. Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity.
    Oxytetracycline dihydrate (Standard)
  • HY-113278R
    Leucyl-phenylalanine (Standard)
    Leucyl-phenylalanine (Standard) is the analytical standard of Leucyl-phenylalanine. This product is intended for research and analytical applications. Leucyl-phenylalanine belongs to the class of organic compounds known as dipeptides.
    Leucyl-phenylalanine (Standard)
  • HY-18252S3
    Avanafil-13C5
    		Modulator
    Avanafil-13C5 (TA1790-13C5) is 13C labeled Avanafil. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis.
    Avanafil-<sup>13</sup>C<sub>5</sub>
  • HY-N0470R
    L-Lysine hydrochloride (Standard)
    L-Lysine hydrochloride (Standard) is the analytical standard of L-Lysine hydrochloride. This product is intended for research and analytical applications. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine hydrochloride (Standard)
  • HY-N7032S
    Uridine 5′-diphosphoglucose-13C disodium
    Uridine 5′-diphosphoglucose-13C (UDP-D-Glucose-13C) disodium is the 13C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032). Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.
    Uridine 5′-diphosphoglucose-<sup>13</sup>C disodium
  • HY-118217
    Cyclanilide
    		99.91%
    Cyclanilide (RPA90946) serves as a plant growth regulator that is applied to cotton during various growth stages.
    Cyclanilide
  • HY-Y0313R
    p-Hydroxybenzaldehyde (Standard)
    p-Hydroxybenzaldehyde (Standard) is the analytical standard of p-Hydroxybenzaldehyde. This product is intended for research and analytical applications. p-Hydroxybenzaldehyde is a one of the major components in vanilla aroma, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.
    p-Hydroxybenzaldehyde (Standard)
  • HY-131511
    Rovicurt
    Rovicurt (Permethrin-tetramethrin mixture) is a pesticide that has the activity of stimulating biological adaptation mechanisms. Rovicurt increases the diameter of seminiferous tubules and the number of Sertoli cells. Rovicurt also improves the fertilizing ability of sperm.
    Rovicurt
  • HY-B0158S8
    Cytidine-d13
    Cytidine-d13 (Cytosine β-D-riboside-d13; Cytosine-1-β-D-ribofuranoside-d13) is deuterium labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine-d<sub>13</sub>
  • HY-171000
    Propiverine N-oxide
    Propiverine N-oxide is the main metabolite of hydrochloride propiverine, and it can affect bladder contractions and saliva secretion in small pigs.
    Propiverine N-oxide
  • HY-W320276
    Dill apiole
    Dill apiole is an aromatic ether, which is an important aroma component in herbs and spices such as dill (Anethum graveolens), parsley (Petroselinum crispum) and basil (Perilla frutescens). Dill apiole exhibits antimicrobial activity against Aspergillus parasiticus and Aedes aegypti.
    Dill apiole
  • HY-N0684S4
    Vitamin K1-d3
    Vitamin K1-d3 (Phylloquinone-d3; Phytomenadione-d3) is deuterium-labeled Vitamin K1 (HY-N0684).
    Vitamin K1-d<sub>3</sub>
  • HY-N11287
    UDP-xylose
    UDP-xylose is an endogenous sugar nucleotide and a catalytic substrate of UDP-xylose synthase (UXS). UDP-xylose is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites and oligosaccharides in plants, vertebrates and fungi, and participates in the synthesis of proteoglycans as a glycosyl donor. UDP-xylose participates in the regulation of the synthesis of extracellular matrix components and can be used to study the mechanism of proteoglycan biosynthesis in glycobiology and related diseases (such as connective tissue diseases)[1][2].
    UDP-xylose
  • HY-127035S1
    Tristearin-13C3
    Tristearin-13C3 (Glycerol tristearate-13C3) is 13C labeled Tristearin. Tristearin is a triglyceride derived from three units of stearic acid.
    Tristearin-13C3
  • HY-113071AR
    Mevalonic acid lithium salt (Standard)
    Mevalonic acid (lithium salt) (Standard) is the analytical standard of Mevalonic acid (lithium salt). This product is intended for research and analytical applications. Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure.
    Mevalonic acid lithium salt (Standard)
  • HY-168382A
    5S(6R)-EET
    5S(6R)-EET is the metabolite of Arachidonic acid (HY-109590). 5S(6R)-EET activates the synthesis of endogenous prostaglandin (PGE2), which inhibits the Na+ absorption, increases the intracellular Ca2+, and promotes the depolarization of transmembrane voltage. 5S(6R)-EET is more active than 5R(6S)-EET (HY-168382).
    5S(6R)-EET
Cat. No. Product Name / Synonyms Application Reactivity