2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-167824
    SSR180711
    SSR180711 is a potent and subtype-selective α7 agonist with activity in Alzheimer's disease and schizophrenia research. SSR180711 can be used to study subtypes of intracerebral hemorrhage associated with cerebral small vessel disease. SSR180711 shows potential in electrophysiological and behavioral studies to evaluate its effects on cognitive function. SSR180711 also has potential for studying cerebrovascular lesions and their effects.
    SSR180711
  • HY-B1295R
    Lithium citrate tetrahydrate (Standard)
    Lithium citrate (tetrahydrate) (Standard) is the analytical standard of Lithium citrate (tetrahydrate). This product is intended for research and analytical applications. Lithium citrate (Litarex) tetrahydrate is a natural preservative and food tartness enhancer. Lithium citrate tetrahydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Lithium citrate tetrahydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Lithium citrate tetrahydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
    Lithium citrate tetrahydrate (Standard)
  • HY-W744739
    Betulinic acid-d3
    Betulinic acid-d3 (Lupatic acid-d3) is a deuterium labeled Betulinic acid (HY-10529). Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties.
    Betulinic acid-d<sub>3</sub>
  • HY-13936R
    1-Methylimidazoleacetic acid (Standard)
    1-Methylimidazoleacetic acid (Standard) is the analytical standard of 1-Methylimidazoleacetic acid. This product is intended for research and analytical applications. 1-Methylimidazoleacetic acid (1-Methylimidazole-4-acetic acid) is a histamine metabolite in urine that can be used in the study of mastocytosis.
    1-Methylimidazoleacetic acid (Standard)
  • HY-113432S1
    Nudifloramide-d6
    Nudifloramide-d6 (2PY-d6) is deuterium-labeled Nudifloramide (HY-113432).
    Nudifloramide-d<sub>6</sub>
  • HY-B0389S13
    D-Glucose-13C-3
    D-Glucose-13C-3 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
    D-Glucose-<sup>13</sup>C-3
  • HY-W013215S
    Adrenic acid-d8
    Adrenic acid-d8 (cis-7,10,13,16-Docosatetraenoic acid-d8) is deuterium-labeled Adrenic acid (HY-W013215).
    Adrenic acid-d<sub>8</sub>
  • HY-B0910
    Pyrithioxin
    Pyrithioxin is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia.
    Pyrithioxin
  • HY-164434
    Xanthosine-5'-monophosphate
    Xanthosine-5'-monophosphate can be obtained by catalyzing inosine 5'-monophosphate (IMP) with inosine 5'-monophosphate dehydrogenase (IMPDH).
    Xanthosine-5'-monophosphate
  • HY-B2167S2
    Docosahexaenoic acid-13C4
    Docosahexaenoic acid-13C4 is 13C labeled Docosahexaenoic acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.
    Docosahexaenoic acid-<sup>13</sup>C<sub>4</sub>
  • HY-113126B
    (R)-3-Hydroxyisobutyric acid sodium
    (R)-3-Hydroxyisobutyric acid (sodium) serves as a biochemical hallmark for the metabolic disorder known as 3-hydroxyisobutyric aciduria, characterized by elevated urinary concentrations.
    (R)-3-Hydroxyisobutyric acid sodium
  • HY-123016
    9(S)-HODE cholesteryl ester
    9(S)-HODE cholesteryl ester is originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation.2 9(S)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.
    9(S)-HODE cholesteryl ester
  • HY-B0430B
    (±)-Pantothenic acid
    (±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice.
    (±)-Pantothenic acid
  • HY-126747
    Corynecin IV
    Corynecin IV is a chloramphenicol-like bacterial metabolite originally isolated from Corynebacterium.
    Corynecin IV
  • HY-110194
    Virodhamine TFA
    Virodhamine TFA is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine TFA induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine TFA can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases.
    Virodhamine TFA
  • HY-112540AR
    Acetoacetic acid lithium (Standard)
    Acetoacetic acid (lithium) (Standard) is the analytical standard of Acetoacetic acid (lithium). This product is intended for research and analytical applications. Acetoacetic acid lithium is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid lithium induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid lithium can be used to study metabolic diseases.
    Acetoacetic acid lithium (Standard)
  • HY-I0352R
    Epiandrosterone (Standard)
    Epiandrosterone (Standard) is the analytical standard of Epiandrosterone. This product is intended for research and analytical applications. Epiandrosterone is a steroid hormone. Epiandrosterone activates BKCa. Epiandrosterone inhibits glucose transport and insulin release. Epiandrosterone has weak androgenic activity.
    Epiandrosterone (Standard)
  • HY-110382S
    13C20,15N10-Cyclic di-GMP sodium
    13C20,15N10-Cyclic di-GMP (13C20,15N10-c-di-GMP) is 13C and 15N labeled Cyclic-di-GMP (disodium). Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research.
    <sup>13</sup>C<sub>20</sub>,<sup>15</sup>N<sub>10</sub>-Cyclic di-GMP sodium
  • HY-N13714
    O-Methylcassythine
    O-Methylcassythine is an aporphine alkaloid, that can be isolated from Cassytha filiformis. O-Methylcassythine exhibits vasodilator activity.
    O-Methylcassythine
  • HY-B0275BR
    Oxytetracycline dihydrate (Standard)
    Oxytetracycline (dihydrate) (Standard) is the analytical standard of Oxytetracycline (dihydrate). This product is intended for research and analytical applications. Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity.
    Oxytetracycline dihydrate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity