2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14608S9
    L-Glutamic acid-15N,d5
    L-Glutamic acid-15N,d5 is the deuterium and 15N-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
    L-Glutamic acid-<sup>15</sup>N,d<sub>5</sub>
  • HY-P2855
    Phenylpyruvate tautomerase
    Phenylpyruvate tautomerase catalyzes the interconversion of the enol and keto isomers of phenylpyruvate and (p-hydroxyphenyl)pyruvate.
    Phenylpyruvate tautomerase
  • HY-134115
    Flumethasone 21-acetate
    Flumethasone 21-acetate (Compound 35) is a type of steroid. Flumethasone 21-acetate has lipophilic properties.
    Flumethasone 21-acetate
  • HY-W127408
    Tripalmitolein
    1,2,3-Tripalmitoleoyl-rac-glycerol is a triacylglycerol containing palmitoleic acid at the sn-1, sn-2 and sn-3 positions. It reduces erythrocyte deformability in a concentration-dependent manner in the Reid filtration assay. Hepatic levels of 1,2,3-tripalmitoleoyl-rac-glycerol are increased in a JAK2L mouse model of hepatic steatosis. 1,2,3-Tripalmitoleoyl-rac-glycerol plasma levels are reduced in patients with predialysis renal disease.
    Tripalmitolein
  • HY-114862
    13,14-dihydro-15(R)-Prostaglandin E1
    13,14-dihydro-15(R)-Prostaglandin E1 (13,14-dihydro-15(R)- PGE1) is an analog of 13,14-dihydro- PGE1 which has the hydroxyl group at C-15 in the unnatural R configuration.
    13,14-dihydro-15(R)-Prostaglandin E1
  • HY-12033S1
    2-Methoxyestradiol-13C6
    2-Methoxyestradiol-13C6 is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa.
    2-Methoxyestradiol-<sup>13</sup>C<sub>6</sub>
  • HY-125818S4
    Cytidine-5'-triphosphate-d14 dilithium
    		98.2%
    Cytidine-5'-triphosphate-d14 (Cytidine triphosphate-d14 dilithium; 5'-CTP-d14) dilithium is deuterium labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
    Cytidine-5'-triphosphate-d<sub>14</sub> dilithium
  • HY-E70315
    Chimax-G
    Chimax-G (Fungal Endo- and Exo- chitosanases) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible.
    Chimax-G
  • HY-Y0740R
    4-Methoxybenzaldehyde (Standard)
    4-Methoxybenzaldehyde (Standard) is the analytical standard of 4-Methoxybenzaldehyde. This product is intended for research and analytical applications. 4-Methoxybenzaldehyde (p-anisaldehyde) is a fragrant phenolic compound. 4-Methoxybenzaldehyde has been found in many plant species including horseradish, anise, star anise. 4-Methoxybenzaldehyde is a possible neurotoxicant and it has shown effects that include mortality, attractancy, and interference with host seeking .
    4-Methoxybenzaldehyde (Standard)
  • HY-W015346R
    Desaminotyrosine (Standard)
    Apronal (Standard) is the analytical standard of Apronal. This product is intended for research and analytical applications. Apronal (Allylisopropylacetylurea, Apronalide) can bu used for the research of neuropsychiatry disorders.
    Desaminotyrosine (Standard)
  • HY-N0326S9
    L-Methionine-15N,d8
    L-Methionine-15N,d8 is the deuterium and 15N-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
    L-Methionine-<sup>15</sup>N,d<sub>8</sub>
  • HY-105747A
    Guanoxyfen nitrate
    Guanoxyfen (N-(3-Phenoxypropyl)guanidine) nitrate is a compound that exhibits potent inhibitory activity against the serine protease enzyme TMPRSS2, which plays a crucial role in the infectivity of coronaviruses. Guanoxyfen nitrate is also an effective inhibitor of vasoconstrictor responses to sympathetic nerve stimulation.
    Guanoxyfen nitrate
  • HY-E70320
    AMK618
    AMK618 (Immobilized cefadroxil acylase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible.
    AMK618
  • HY-W725504
    2-Hydroxy-3-methylbutanoic acid-d7
    2-Hydroxy-3-methylbutanoic acid-d7 is the deuterium labeled 2-Hydroxy-3-methylbutanoic acid (HY-W008150). 2-Hydroxy-3-methylbutanoic acid is an α-hydroxy analogue of valine and a valine precursor that reduces urea excretion. 2-Hydroxy-3-methylbutanoic acid can promote the growth of chickens and rats, and is converted into valine in the body, participating in protein synthesis and maintaining nitrogen balance, thereby supporting animal growth and development. 2-Hydroxy-3-methylbutanoic acid has a more significant effect on the valine-deficient dietary model. 2-Hydroxy-3-methylbutanoic acid is mainly used in animal nutrition research to evaluate its potential application as a nitrogen source substitute in feed.
    2-Hydroxy-3-methylbutanoic acid-d<sub>7</sub>
  • HY-E70311
    TLL-10X
    TLL-10X (Thermomyces lanuginosus lipase) is a high-efficiency biocatalyst, a lipase from Thermomyces lanuginosus. TLL-10X can be conjugated to magnetic nanoparticles and coupled to the surface of Fe(3)O(4)-COOH to obtain better temperature resistance and pH resistance. The activity unit (U) of lipase is defined as the amount of enzyme that produces 1 μmol of fatty acid per minute under experimental conditions.
    TLL-10X
  • HY-113801R
    N-(3-Oxooctanoyl)-DL-homoserine lactone (Standard)
    4-Epitetracycline (hydrochloride) (Standard) is the analytical standard of 4-Epitetracycline (hydrochloride). This product is intended for research and analytical applications. 4-Epitetracycline hydrochloride is an epimer of Tetracycline.html" class="link-product" target="_blank">Tetracycline (HY-A0107). Tetracycline can undergo epimerization in solution to 4-Epitetracycline hydrochloride, which shows a much lower antibiotic activity.
    N-(3-Oxooctanoyl)-DL-homoserine lactone (Standard)
  • HY-Y0252S6
    L-Proline-13C5,15N,d7
    L-Proline-13C5,15N,d7 is the deuterium, 13C and 15N labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
    L-Proline-<sup>13</sup>C<sub>5</sub>,<sup>15</sup>N,d<sub>7</sub>
  • HY-N0378S5
    D-Mannitol-d
    D-Mannitol-d is the deuterium labeled D-Mannitol.
    D-Mannitol-d
  • HY-W015883AS
    Fumaric acid2,3-13C2 disodium
    Fumaric acid2,3-13C2 (disodium) is the deuterium labeled Fumaric acid disodium.
    Fumaric acid2,3-<sup>13</sup>C<sub>2</sub> disodium
  • HY-W001132S3
    Indole-15N
    Indole-15N is the 15N labeled Indole. Indole is an endogenous metabolite.
    Indole-<sup>15</sup>N
Cat. No. Product Name / Synonyms Application Reactivity