2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-129546
    Eprozinol hydrochloride
    Eprozinol hydrochloride is a compound with antibronchoconstrictor activity. Eprozinol hydrochloride can be used in the study of bronchospasm.
    Eprozinol hydrochloride
  • HY-N0379S18
    D-Mannose-13C6,d7
    D-mannose-13C6,d7 is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote.
    D-Mannose-<sup>13</sup>C<sub>6</sub>,d<sub>7</sub>
  • HY-N0210S2
    D-Galactose-13C-3
    D-Galactose-13C-3 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
    D-Galactose-<sup>13</sup>C-3
  • HY-B0442AS
    Vardenafil-d5 hydrochloride
    Vardenafil-d5 hydrochloride is deuterated labeled Vardenafil hydrochloride (HY-B0442A). Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4. Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil hydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes[1]-[6].
    Vardenafil-d<sub>5</sub> hydrochloride
  • HY-111487
    α-Methylacyl-CoA racemase 1
    α-methylacyl-CoA racemase 1 is an enzyme that catalyzes a key chiral inversion step in the metabolism of branched-chain fatty acids, and used as a maker in prostate and other cancer.
    α-Methylacyl-CoA racemase 1
  • HY-30152R
    Xanthotoxol (Standard)
    Xanthotoxol (Standard) is the analytical standard of Xanthotoxol. This product is intended for research and analytical applications. Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.
    Xanthotoxol (Standard)
  • HY-N2325S
    D-(+)-Cellobiose-13C
    D-(+)-Cellobiose-13C is the 13C labeled D-(+)-Cellobiose. D-(+)-Cellobiose is an endogenous metabolite.
    D-(+)-Cellobiose-<sup>13</sup>C
  • HY-125114
    Jatrophane 4
    Jatrophane 4 is a secondary metabolite of Euphorbia peplus. Jatrophane 4 is a diterpene.
    Jatrophane 4
  • HY-B0451AR
    Dopamine hydrochloride (Standard)
    Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
    Dopamine hydrochloride (Standard)
  • HY-114646
    TMC-205
    TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter.
    TMC-205
  • HY-W013636AR
    2-Ketoglutaric acid Sodium (Standard)
    2-Ketoglutaric acid (Sodium) (Standard) is the analytical standard of 2-Ketoglutaric acid Sodium (HY-W013636A). This product is intended for research and analytical applications. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) Sodium (Standard) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM).
    2-Ketoglutaric acid Sodium (Standard)
  • HY-145528
    Heptanoyl-L-carnitine chloride
    Heptanoyl-L-carnitine chloride (trans-3,4-methylene-heptanoylcarnitine) is an acylcarnitine. Heptanoyl-L-carnitine chloride causes exercise-induced alterations in the human metabolome in plasma and skeletal muscle tissue.
    Heptanoyl-L-carnitine chloride
  • HY-N6692S
    Diacetoxyscirpenol-13C19
    Diacetoxyscirpenol-13C19 is 13C labeled Diacetoxyscirpenol (HY-N6692). Diacetoxyscirpenol (DAS) is a trichothecene mycotoxin, a secondary metabolite product of fungi. Diacetoxyscirpenol (DAS) consumption induces haematological disorders (neutropenia, aplastic anemia) in human and animals.
    Diacetoxyscirpenol-<sup>13</sup>C<sub>19</sub>
  • HY-165053
    1,3-Distearoyl-2-palmitoyl glycerol
    1,3-Distearoyl-2-palmitoyl glycerol (1,3-Stearin-2-palmitin) is a compound mentioned in the study of the triglyceride composition of bovine milk fat. It was analyzed and identified by multiple chromatographic techniques, and a total of 120 triglycerides were identified.
    1,3-Distearoyl-2-palmitoyl glycerol
  • HY-121385S1
    Hydroxy Bosentan-d4
    Hydroxy Bosentan-d4 is deuterium labeled Hydroxy bosentan. Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities.
    Hydroxy Bosentan-d<sub>4</sub>
  • HY-B0389S32
    D-Glucose-18O-3
    D-Glucose-18O-3 is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecule
    D-Glucose-<sup>18</sup>O-3
  • HY-117760
    Spirolaxine
    Spirolaxine is a plant growth inhibitor and possess significant anti-Helicobacter pylori activity. Spirolaxine exhibits cholesterol-lowering activity.
    Spirolaxine
  • HY-113350
    Thromboxane A2
    Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses.
    Thromboxane A2
  • HY-113019S
    3β,7α-Dihydroxycholest-5-enoic acid-d3
    		99.5%
    3β,7α-Dihydroxycholest-5-enoic acid-d3 is deuterium labeled 3β,7α-Dihydroxycholest-5-enoic acid.
    3β,7α-Dihydroxycholest-5-enoic acid-d<sub>3</sub>
  • HY-W768245
    a-D-Galactose-1,2-13C2 1-phosphate potassium
    a-D-Galactose-1,2-13C2 1-phosphate potassium is the 13C- and 15N-labeled a-D-Galactose (HY-121370). α-D-Galactose is a non-starch polysaccharide found in the bulb tissues of Lilium davidii var. unicolor Salisb. α-D-Galactose has anti-oxidation properties, anti-tumour activities, immunomodulatory effects and anti-HIV functions.
    a-D-Galactose-1,2-<sup>13</sup>C<sub>2</sub> 1-phosphate potassium
Cat. No. Product Name / Synonyms Application Reactivity