2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113338A
    8-Hydroxyguanine hydrochloride
    8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage.
    8-Hydroxyguanine hydrochloride
  • HY-E70328
    Alkalophilic Proteinase, Streptomyces sp
    Alkalophilic Proteinase, Streptomyces sp is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible.
    Alkalophilic Proteinase, Streptomyces sp
  • HY-E70163
    Carbohydrate Sulfotransferase 3
    Carbohydrate Sulfotransferase 3 (EC:2.8.2.17) can catalyze sulphate transfer to position 6 of GalNAc residue of chondroitin.
    Carbohydrate Sulfotransferase 3
  • HY-113405S
    21-Desoxycortisol-d4
    21-Desoxycortisol-d4 is the deuterium labeled 21-Desoxycortisol.
    21-Desoxycortisol-d<sub>4</sub>
  • HY-117679
    LY 135114 free base
    LY 135114 free base is a metabolite with antitumor activity. LY 135114 free base is a metabolite of LY 195448, a phenylethanolamine compound with antitumor activity. LY 135114 free base has shown potential biological activity in research and may be used for cancer inhibition.
    LY 135114 free base
  • HY-145537
    1,3-Dipalmitoyl-2-eicosapentaenoyl glycerol
    1,3-Dipalmitoyl-2-eicosapentaenoyl glycerol is a positional isomer of triglyceride that can affect lipid metabolism.
    1,3-Dipalmitoyl-2-eicosapentaenoyl glycerol
  • HY-134129
    Benzoyl coenzyme A
    Benzoyl coenzyme A (Benzoyl CoA) is A derivative of Coenzyme A (CoA) in which the mercaptan group of CoA binds to the benzoyl group. Benzoyl coenzyme A is involved in the catalytic reaction as a substrate for the acyl transfer reaction. Benzoyl coenzyme A is a versatile metabolic intermediate that can be used to reveal substrate specificity of enzymes, metabolic regulation, and drug metabolism.
    Benzoyl coenzyme A
  • HY-B0539R
    Desloratadine (Standard)
    Desloratadine (Standard) is the analytical standard of Desloratadine. This product is intended for research and analytical applications. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities.
    Desloratadine (Standard)
  • HY-115899
    Malonyl CoA
    Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1.
    Malonyl CoA
  • HY-A0132S3
    N-Acetyl-D-glucosamine-2-13C
    N-Acetyl-D-glucosamine-2-13C is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc.
    N-Acetyl-D-glucosamine-2-<sup>13</sup>C
  • HY-B2176D
    ATP ditromethamine
    ATP ditromethamine (Adenosine 5'-triphosphate ditromethamine) is a central component of energy storage and metabolism in vivo. ATP ditromethamine provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP ditromethamine is an important endogenous signaling molecule in immunity and inflammation.
    ATP ditromethamine
  • HY-E70236
    CoA-S-S-CoA
    CoA–S-S–CoA is an endogenous metabolite found inP. furiousus. CoA–S-S–CoA is a substrate of NOXA2.
    CoA-S-S-CoA
  • HY-W049735R
    N,N,O-Tridesmethylvenlafaxine (Standard)
    Vardenafil (dihydrochloride) (Standard) is the analytical standard of Vardenafil (dihydrochloride). This product is intended for research and analytical applications. Vardenafil dihydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil dihydrochloride shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM respectively, while IC50s are >1000 nM for PDE3 and PDE4. Vardenafil dihydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil dihydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes-.
    N,N,O-Tridesmethylvenlafaxine (Standard)
  • HY-N0667S3
    L-Asparagine-13C4 monohydrate
    L-Asparagine-13C4 monohydrate is the 13C-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine-<sup>13</sup>C<sub>4</sub> monohydrate
  • HY-N1272
    Secaubryenol
    Secaubryenol is a class of 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla. Secaubryenol does not display any cytotoxic effect at a dose of 10 μg/mL.
    Secaubryenol
  • HY-E70341
    Histamine N-methyl transferase, rat
    Histamine N-methyl transferase, rat is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible.
    Histamine N-methyl transferase, rat
  • HY-129878
    N-Trifluoroacetyladriamycin
    N-Trifluoroacetyladriamycin (AD-41) is a chemotherapeutic compound with antitumor activity. N-Trifluoroacetyladriamycin exhibits the highest fluorescence and radioactivity levels in the small intestine and liver, indicating its significant accumulation in these tissues. N-Trifluoroacetyladriamycin also shows significant accumulation in the kidney, spleen, large intestine, lung, and heart. N-Trifluoroacetyladriamycin is a metabolite of Valrubicin, which is used to inhibit bladder cancer. The presence of N-Trifluoroacetyladriamycin and its derivatives may be related to the biotransformation of the compound and its antitumor mechanism.
    N-Trifluoroacetyladriamycin
  • HY-111499
    Emopamil
    Emopamil is an inhibitor of calcium channel that can reduce ischemia-induced neuronal cell damage.
    Emopamil
  • HY-W009371A
    D-Ribose 5-phosphate
    D-Ribose 5-phosphate is an intermediate of the oxidative branch of the pentose phosphate pathway (PPP) and an end product of the nonoxidative branch of the PPP. D-Ribose 5-phosphate is used in the synthesis of nucleotides and nucleic acids.
    D-Ribose 5-phosphate
  • HY-142908
    Maximiscin
    Maximiscin, a fungal metabolite, induces DNA damage and shows selective cytotoxic activity against a subtype of triple-negative breast cancer.
    Maximiscin
Cat. No. Product Name / Synonyms Application Reactivity