2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-110189S
    Pregnenolone monosulfate sodium-13C2,d2
    Pregnenolone monosulfate (sodium)-13C2,d2 is the 13C- and deuterium labeled Pregnenolone monosulfate sodium. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium salt is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.
    Pregnenolone monosulfate sodium-<sup>13</sup>C<sub>2</sub>,d<sub>2</sub>
  • HY-N1423AR
    Glycocholic acid sodium (Standard)
    Glycocholic acid (sodium) (Standard) is the analytical standard of Glycocholic acid (sodium). This product is intended for research and analytical applications. Glycocholic acid sodium is an orally active bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1].
    Glycocholic acid sodium (Standard)
  • HY-N15224
    15-Hydroxy-3,11,23-trioxolanost-8,20-dien-26-oic acid
    15-Hydroxy-3,11,23-trioxolanost-8,20-dien-26-oic acid (comound 35) is a triterpenoid that can be isolated from Ganoderma lucidum.
    15-Hydroxy-3,11,23-trioxolanost-8,20-dien-26-oic acid
  • HY-E70294
    N-Acetylgalactosaminyltransferase 13
    N-Acetylgalactosaminyltransferase 13 (GALNT13) is a glycosaminyltransferase. N-Acetylgalactosaminyltransferase 13 participates in neuronal differentiation by glycosylating and stabilizing PDPN.
    N-Acetylgalactosaminyltransferase 13
  • HY-113332R
    Myristoleic acid (Standard)
    Myristoleic acid (Standard) is the analytical standard of Myristoleic acid. This product is intended for research and analytical applications. Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells[1].
    Myristoleic acid (Standard)
  • HY-121656
    AKR1C2/3-IN-2
    AKR1C2/3-IN-2 is a potential AKR1C3 inhibitor with selective AKR1C3 activity. AKR1C2/3-IN-2 is able to block AKR1C3-mediated testosterone (T) production and PSA induction, affecting the endocrine activity of prostate cancer cells. AKR1C2/3-IN-2 shows selectivity over other AKR1C enzymes, indicating its potential application in inhibiting drug-resistant prostate cancer. AKR1C2/3-IN-2 has no inhibitory activity against COX isomerases, further emphasizing its specificity as a prostate cancer inhibitory compound.
    AKR1C2/3-IN-2
  • HY-N0379S13
    D-Mannose-d-2
    D-Mannose-d-2 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
    D-Mannose-d-2
  • HY-113305
    Dopamine 3-O-sulfate
    Dopamine 3-O-sulfate mainly exists in plasma and can be used as a biomarker to characterize aromatic amino acid decarboxylase (AADC) deficiency.
    Dopamine 3-O-sulfate
  • HY-W007686R
    Imidazoleacetic acid hydrochloride (Standard)
    Imidazoleacetic acid (hydrochloride) (Standard) is the analytical standard of Imidazoleacetic acid (hydrochloride). This product is intended for research and analytical applications. Imidazoleacetic acid hydrochloride is a γ-aminobutyric acid receptor agonist. Imidazoleacetic acid hydrochloride inhibits GABA-T in a non-competitive manner, with a Ki value of 0.34 mM. Imidazoleacetic acid hydrochloride increases total free GABA in brain[1][2][3].
    Imidazoleacetic acid hydrochloride (Standard)
  • HY-113166R
    Dodecanoylcarnitine (Standard)
    Dodecanoylcarnitine (Standard) is the analytical standard of Dodecanoylcarnitine. This product is intended for research and analytical applications. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma.
    Dodecanoylcarnitine (Standard)
  • HY-168764
    C16 Galactosylceramide
    		98.00%
    C16 Galactosylceramide is a sphingolipid compound. C16 Galactosylceramide participates in the physiological processes of lipid metabolism and immune regulation in cells. C16 Galactosylceramide can be used in the study of diabetes.
    C16 Galactosylceramide
  • HY-W654255
    Mandelic Acid-13C8
    Mandelic Acid-13C8 ((±)-Mandelic acid-13C8) is the 13C-labeled Mandelic acid (HY-W015591). Mandelic acid ((±)-Mandelic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. Mandelic acid shows antimicrobial activity and has been used for the research of urinary tract infections and vaginal trichomoniasis. Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation.
    Mandelic Acid-<sup>13</sup>C<sub>8</sub>
  • HY-104026S1
    L-Kynurenine-d4-1
    L-Kynurenine-d4-1 is deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
    L-Kynurenine-d<sub>4</sub>-1
  • HY-N10205
    Rostratin C
    Rostratin C, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 value of 0.76μg /mL.
    Rostratin C
  • HY-N7092S7
    D-Fructose-6-13C
    		≥98.0%
    D-Fructose-6-13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
    D-Fructose-6-<sup>13</sup>C
  • HY-N0210S9
    D-Galactose-d2
    D-Galactose-d2 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
    D-Galactose-d<sub>2</sub>
  • HY-117578
    KB 5666
    KB 5666 is a benzoxazine derivative with lipid peroxidation inhibitory activity. KB 5666 showed protective effects against post-ischemic neuronal death. KB 5666 effectively protected CA1 neurons when injected 5 minutes before or immediately after ischemia. KB 5666 also showed a dose-dependent protective effect when injected within 1 hour after ischemia. KB 5666 effectively prevented the significant decrease in microtubule-associated protein 2 immunoreactivity within the dendritic field of CA1 pyramidal cells. KB 5666 prevented the decrease in [3H]PDBu binding activity in different layers of the CA1 region after ischemia. The application of KB 5666 showed the ability to improve the cellular and functional consequences of ischemia.
    KB 5666
  • HY-125848R
    Ginsenoside F2 (Standard)
    Ginsenoside F2 (Standard) is the analytical standard of Ginsenoside F2. This product is intended for research and analytical applications. Ginsenoside F2, a metabolite from Ginsenoside Rb1, induces apoptosis accompanied by protective autophagy in breast cancer stem cells.
    Ginsenoside F2 (Standard)
  • HY-B0228S3
    Adenosine-3′-13C
    Adenosine-3′-13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo
    Adenosine-3′-<sup>13</sup>C
  • HY-128743R
    12-Hydroxydodecanoic acid (Standard)
    Methyl isoeugenol (Standard) is the analytical standard of Methyl isoeugenol. This product is intended for research and analytical applications. Methyl isoeugenol (MIE) is a natural food flavour that can be isolated from Pimenta pseudocaryophyllus leaf. Methyl isoeugenol shows anxiolytic and antidepressant like effects. Methyl isoeugenol is orally active.
    12-Hydroxydodecanoic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity