2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P3570
    Adipokinetic hormone II (Locusta migratoria)
    		Inducer
    Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs).
    Adipokinetic hormone II (Locusta migratoria)
  • HY-N0010R
    Geniposidic acid (Standard)
    Geniposidic acid (Standard) is the analytical standard of Geniposidic acid. This product is intended for research and analytical applications. Geniposidic acid has radiation protection and anti-cancer activity.
    Geniposidic acid (Standard)
  • HY-P2966
    Protein-arginine deiminase
    Protein-arginine deiminase is a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline.
    Protein-arginine deiminase
  • HY-B0421AR
    Mycophenolic acid (sodium) (Standard)
    Mycophenolic acid (sodium) (Standard) is the analytical standard of Mycophenolic acid (sodium). This product is intended for research and analytical applications. Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects.
    Mycophenolic acid (sodium) (Standard)
  • HY-W041470R
    4-Methyl-1-phenyl-2-pentanone (Standard)
    Chlorpromazine (hydrochloride) (Standard) is the analytical standard of Chlorpromazine (hydrochloride). This product is intended for research and analytical applications. Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis.
    4-Methyl-1-phenyl-2-pentanone (Standard)
  • HY-12033S
    2-Methoxyestradiol-13C,d3
    2-Methoxyestradiol-13C,d3 is the 13C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].
    2-Methoxyestradiol-<sup>13</sup>C,d<sub>3</sub>
  • HY-135212S
    Hydroxy ipronidazole-d3
    Hydroxy ipronidazole-d3 is the deuterium labeled Hydroxy ipronidazole. Hydroxy ipronidazole (Ipronidazole-OH) is a metabolite of nitroimidazole antibiotics, such as ipronidazole (IPZ). Hydroxy ipronidazole may has similar mutagenic potential as the parent compound[1].
    Hydroxy ipronidazole-d<sub>3</sub>
  • HY-N7092S16
    D-Fructose-d2
    D-Fructose-d2 is the deuterium labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
    D-Fructose-d<sub>2</sub>
  • HY-128746S1
    2,6-Diaminoheptanedioic acid-15N2
    2,6-Diaminoheptanedioic acid-15N2 is 15N labeled 2,6-Diaminoheptanedioic acid (HY-128746). 2,6-Diaminoheptanedioic acid is an endogenous metabolite.
    2,6-Diaminoheptanedioic acid-<sup>15</sup>N<sub>2</sub>
  • HY-17552R
    sn-Glycero-3-phosphocholine (Standard)
    sn-Glycero-3-phosphocholine (Standard) is the analytical standard of sn-Glycero-3-phosphocholine. This product is intended for research and analytical applications. sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia[1][2].
    sn-Glycero-3-phosphocholine (Standard)
  • HY-125863B
    Glucose 6-phosphate dehydrogenase (yeast, recombinant)
    Glucose 6-phosphate dehydrogenase (yeast, recombinant) is the rate-limiting enzyme of the pentose phosphate pathway and a major source of NADPH in antioxidant pathways, nitric oxide synthase, NADPH oxidase, and cytochrome P450 systems. Glucose 6-phosphate dehydrogenase helps cells resist oxidative stress and regulates metabolic rates. It holds potential for research in fields such as diabetes, endothelial dysfunction, cancer, and cardiomyopathy.
    Glucose 6-phosphate dehydrogenase (yeast, recombinant)
  • HY-W010256S1
    D-Xylulose-2-13C
    D-Xylulose-2-13C is the 13C labeled D-Xylulose. D-xylulose is a precursor of the pentiol D-arabi[1][2].
    D-Xylulose-2-<sup>13</sup>C
  • HY-B1465S
    1-Hexadecanol-d31
    1-Hexadecanol-d31 is the deuterium labeled 1-Hexadecanol[1]. 1-Hexadecanol is a fatty alcohol, a lipophilic substrate[2].
    1-Hexadecanol-d<sub>31</sub>
  • HY-N15223
    [(2E,4E)-Octadienoyl]-N-isobutylamide
    [(2E,4E)-Octadienoyl]-N-isobutylamide (compound 2) is an isobutylamide that can be isolated from pepper seeds.
    [(2E,4E)-Octadienoyl]-N-isobutylamide
  • HY-N0132B
    Synephrine hemitartrate
    Synephrine (Oxedrine) hemitartrate, an alkaloid, is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium. Synephrine hemitartrate is a sympathomimetic compound and can be used for weight loss.
    Synephrine hemitartrate
  • HY-113263R
    17a-Hydroxypregnenolone (Standard)
    17a-Hydroxypregnenolone (Standard) is the analytical standard of 17a-Hydroxypregnenolone. This product is intended for research and analytical applications. 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).
    17a-Hydroxypregnenolone (Standard)
  • HY-W013014R
    3-Methyl-2-cyclopenten-1-one (Standard)
    3-Methyl-2-cyclopenten-1-one (Standard) is the analytical standard of 3-Methyl-2-cyclopenten-1-one. This product is intended for research and analytical applications. 3-Methyl-2-cyclopenten-1-one is an endogenous metabolite.
    3-Methyl-2-cyclopenten-1-one (Standard)
  • HY-D0850R
    Tartaric acid disodium dihydrate (Standard)
    Tartaric acid (disodium dihydrate) (Standard) is the analytical standard of Tartaric acid (disodium dihydrate). This product is intended for research and analytical applications. Tartaric acid disodium dehydrate (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. Tartaric acid disodium dehydrate has vasodilatory and antihypertensive effects. Tartaric acid disodium dehydrate can be used as flavorings and antioxidants in a range of foods and beverages. Tartaric acid disodium dehydrate can be used in laser frequency doubling and optical limiting applications[4].
    Tartaric acid disodium dihydrate (Standard)
  • HY-10572S1
    Efavirenz-13C6
    Efavirenz-13C6 is the 13C-labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1].
    Efavirenz-<sup>13</sup>C<sub>6</sub>
  • HY-P1067A
    Enterostatin(human,mouse,rat) TFA
    Enterostatin (human,mouse,rat) TFA is a pentapeptide mainly formed in the intestine by the cleavage of secreted pancreatic procolipase. Enterostatin  selectively reduces fat intake, bodyweight, and body fat in vivo.
    Enterostatin(human,mouse,rat) TFA
Cat. No. Product Name / Synonyms Application Reactivity