2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P2039
    Retrobradykinin
    Retrobradykinin has the reverse sequence of Bradykinin (HY-P0206). Retrobradykinin exhibits no kinin activity and can be used as a negative control for Bradykinin.
    Retrobradykinin
  • HY-W747564
    (+/-)12-HpETE
    (+/-)12-HpETE is a 12-hydroxyicosatetraenoic acid product by lipoxygenase. (+/-)12-HpETE has vasodilator action.
    (+/-)12-HpETE
  • HY-115387
    Oleoyl proline
    Oleoyl proline is a novel N-acyl amine compound.
    Oleoyl proline
  • HY-W250315
    Polypectate sodium
    Polypectate sodium is a major component of cell wall polysaccharides (pectins) and is used as a carbon source and inducer of polygalacturonase. Polypectate sodium can also be used to evaluate alkaline active and alkaline stable pectate lyases from Streptomyces spp. and to study the optimization of polygalacturonase production from Xanthophyllum spp. and reaction conditions.
    Polypectate sodium
  • HY-18258S
    Berberine-d6 chloride
    Berberine-d6 (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties[1].
    Berberine-d<sub>6</sub> chloride
  • HY-Y0488AR
    Formic acid (ammonium) (Standard)
    Formic acid (ammonium) (Standard) is the analytical standard of Formic acid (ammonium). This product is intended for research and analytical applications. Formic acid ammonium salt is an endogenous metabolite.
    Formic acid (ammonium) (Standard)
  • HY-110189S
    Pregnenolone monosulfate sodium-13C2,d2
    Pregnenolone monosulfate (sodium)-13C2,d2 is the 13C- and deuterium labeled Pregnenolone monosulfate sodium. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium salt is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
    Pregnenolone monosulfate sodium-<sup>13</sup>C<sub>2</sub>,d<sub>2</sub>
  • HY-N1423AR
    Glycocholic acid sodium (Standard)
    Glycocholic acid (sodium) (Standard) is the analytical standard of Glycocholic acid (sodium). This product is intended for research and analytical applications. Glycocholic acid sodium is an orally active bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1].
    Glycocholic acid sodium (Standard)
  • HY-N15224
    15-Hydroxy-3,11,23-trioxolanost-8,20-dien-26-oic acid
    15-Hydroxy-3,11,23-trioxolanost-8,20-dien-26-oic acid (comound 35) is a triterpenoid that can be isolated from Ganoderma lucidum.
    15-Hydroxy-3,11,23-trioxolanost-8,20-dien-26-oic acid
  • HY-E70294
    N-Acetylgalactosaminyltransferase 13
    N-Acetylgalactosaminyltransferase 13 (GALNT13) is a glycosaminyltransferase. N-Acetylgalactosaminyltransferase 13 participates in neuronal differentiation by glycosylating and stabilizing PDPN.
    N-Acetylgalactosaminyltransferase 13
  • HY-113332R
    Myristoleic acid (Standard)
    Myristoleic acid (Standard) is the analytical standard of Myristoleic acid. This product is intended for research and analytical applications. Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells[1].
    Myristoleic acid (Standard)
  • HY-121656
    AKR1C2/3-IN-2
    AKR1C2/3-IN-2 is a potential AKR1C3 inhibitor with selective AKR1C3 activity. AKR1C2/3-IN-2 is able to block AKR1C3-mediated testosterone (T) production and PSA induction, affecting the endocrine activity of prostate cancer cells. AKR1C2/3-IN-2 shows selectivity over other AKR1C enzymes, indicating its potential application in inhibiting drug-resistant prostate cancer. AKR1C2/3-IN-2 has no inhibitory activity against COX isomerases, further emphasizing its specificity as a prostate cancer inhibitory compound.
    AKR1C2/3-IN-2
  • HY-N0379S13
    D-Mannose-d-2
    D-Mannose-d-2 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
    D-Mannose-d-2
  • HY-113305
    Dopamine 3-O-sulfate
    Dopamine 3-O-sulfate mainly exists in plasma and can be used as a biomarker to characterize aromatic amino acid decarboxylase (AADC) deficiency.
    Dopamine 3-O-sulfate
  • HY-W004114
    N-Acetyl-L-proline
    N-Acetyl-L-proline is aproline derivatives.
    N-Acetyl-L-proline
  • HY-W007686R
    Imidazoleacetic acid hydrochloride (Standard)
    Imidazoleacetic acid (hydrochloride) (Standard) is the analytical standard of Imidazoleacetic acid (hydrochloride). This product is intended for research and analytical applications. Imidazoleacetic acid hydrochloride is a γ-aminobutyric acid receptor agonist. Imidazoleacetic acid hydrochloride inhibits GABA-T in a non-competitive manner, with a Ki value of 0.34 mM. Imidazoleacetic acid hydrochloride increases total free GABA in brain[1][2][3].
    Imidazoleacetic acid hydrochloride (Standard)
  • HY-113166R
    Dodecanoylcarnitine (Standard)
    Dodecanoylcarnitine (Standard) is the analytical standard of Dodecanoylcarnitine. This product is intended for research and analytical applications. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease.
    Dodecanoylcarnitine (Standard)
  • HY-168764
    C16 Galactosylceramide
    C16 Galactosylceramide is a sphingolipid compound. C16 Galactosylceramide participates in the physiological processes of lipid metabolism and immune regulation in cells. C16 Galactosylceramide can be used in the study of diabetes.
    C16 Galactosylceramide
  • HY-104026S1
    L-Kynurenine-d4-1
    L-Kynurenine-d4-1 is deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
    L-Kynurenine-d<sub>4</sub>-1
  • HY-N10205
    Rostratin C
    Rostratin C, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 value of 0.76μg /mL.
    Rostratin C
Cat. No. Product Name / Synonyms Application Reactivity