2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125954
    Uridine diphosphate glucuronic acid
    Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum.
    Uridine diphosphate glucuronic acid
  • HY-W015851S
    3-Hydroxybutanoic acid-13C sodium
    3-Hydroxybutanoic acid-13C-13C (sodium) is the 13C labeled 3-Hydroxybutanoic acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids.
    3-Hydroxybutanoic acid-<sup>13</sup>C sodium
  • HY-W013061S10
    Propane-1,2,3-triyl tripalmitate-13C
    Propane-1,2,3-triyl tripalmitate-13C is the 13C labeled Propane-1,2,3-triyl tripalmitate[1]. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
    Propane-1,2,3-triyl tripalmitate-<sup>13</sup>C
  • HY-Y1373R
    Cyclohexanecarboxylic acid (Standard)
    Cyclohexanecarboxylic acid (Standard) is the analytical standard of Cyclohexanecarboxylic acid. This product is intended for research and analytical applications. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action.
    Cyclohexanecarboxylic acid (Standard)
  • HY-W179801
    1,3-Diphenethylurea
    		≥98.0%
    1,3-Diphenethylurea is a compound derived from marine sources, exhibiting anti-cancer activity. 1,3-Diphenethylurea has been shown to potentially inhibit tumor growth. 1,3-Diphenethylurea contributes to the development of novel therapeutic strategies in fighting cancer.
    1,3-Diphenethylurea
  • HY-126230
    PAT-494
    PAT-494 is an ATX inhibitor with significant activity in biochemical and plasma assays. PAT-494 can reduce LPA levels in rat plasma through oral administration. The structure-activity relationship study of PAT-494 shows that its binding mode with ATX is novel and it can effectively occupy the hydrophobic pockets and channels of ATX.
    PAT-494
  • HY-118576
    Histidylprolineamide
    Histidylprolineamide (His-pro-amide) is a reactive amide, an intermediate in the histidine metabolic pathway.
    Histidylprolineamide
  • HY-100582S3
    Ribitol-5-13C
    Ribitol-5-13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
    Ribitol-5-<sup>13</sup>C
  • HY-Y1809R
    1-Hydroxyoctadecane (Standard)
    1-Hydroxyoctadecane (Standard) is the analytical standard of 1-Hydroxyoctadecane. This product is intended for research and analytical applications. 1-Hydroxyoctadecane is an endogenous metabolite.
    1-Hydroxyoctadecane (Standard)
  • HY-N0593B
    Deoxycholic acid sodium hydrate
    Deoxycholic acid (cholanoic acid) sodium hydrate, a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5.
    Deoxycholic acid sodium hydrate
  • HY-N7092S20
    D(-​)​-​Fructose-18O-1
    D(-​)​-​Fructose-18O-1 is the 18O labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
    D(-​)​-​Fructose-<sup>18</sup>O-1
  • HY-N0473S13
    L-Tyrosine-d2-2
    L-Tyrosine-d2-2 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-d<sub>2</sub>-2
  • HY-E70297
    N-Acetylglucosaminyltransferase IVa
    N-Acetylglucosaminyltransferase IVa (MGAT4A) is a glycosyltransferase that can enhance the migration, invasion, and adhesion abilities of cancer cells, and increase β1,4GlcNAc branched glycans on integrin β1 (ITGB1), a tumor-associated glycoprotein closely related to cell motility.
    N-Acetylglucosaminyltransferase IVa
  • HY-W017443S4
    L-Asparagine-1,2,3,4-13C4 monohydrate
    L-Asparagine-1,2,3,4-13C4 monohydrate is the 13C labeled labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine-1,2,3,4-<sup>13</sup>C<sub>4</sub> monohydrate
  • HY-30004R
    1-Aminocyclopropane-1-carboxylic acid (Standard)
    1-Aminocyclopropane-1-carboxylic acid (Standard) is the analytical standard of 1-Aminocyclopropane-1-carboxylic acid. This product is intended for research and analytical applications. 1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity..
    1-Aminocyclopropane-1-carboxylic acid (Standard)
  • HY-108568R
    15-Deoxy-Δ-12,14-prostaglandin J2 (Standard)
    15-Deoxy-Δ-12,14-prostaglandin J2 (Standard) is the analytical standard of 15-Deoxy-Δ-12,14-prostaglandin J2. This product is intended for research and analytical applications. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 μM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM.
    15-Deoxy-Δ-12,14-prostaglandin J2 (Standard)
  • HY-B0539S4
    Desloratadine-d4 hydrobromide
    Desloratadine-d4 hydrobromide is deuterated labeled Desloratadine (HY-B0539). Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities.
    Desloratadine-d<sub>4</sub> hydrobromide
  • HY-N0576R
    Solanesol (Standard)
    Solanesol (Standard) is the analytical standard of Solanesol. This product is intended for research and analytical applications. Solanesol is an aliphatic terpene alcohol mainly found in Solanaceous plants, with anti-inflammatory, neuroprotective, and antimicrobial activities.
    Solanesol (Standard)
  • HY-W748594
    Apigenin triacetate
    Apigenin triacetate is a metabolite of F. graminearum. Apigenin triacetate can be downregulated in F. graminearum by chitosan treatment. Apigenin triacetate derives from apigenin.
    Apigenin triacetate
  • HY-107469R
    Pyridoxal (Standard)
    Pyridoxal (Standard) is the analytical standard of Pyridoxal. This product is intended for research and analytical applications. Pyridoxal is a neuroprotectant. Pyridoxal is one of the main forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-pyridoxic acid (HY-113493) and excreted in the urine. Pyridoxal has shown promise in the study of carpal tunnel syndrome (CTS)[1][2][3].
    Pyridoxal (Standard)
Cat. No. Product Name / Synonyms Application Reactivity