2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glycosidase

Glycosidase

Glycosidase

Glycosidase

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Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N7377
    Butyl isobutyl phthalate
    		Inhibitor 99.31%
    Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment.
    Butyl isobutyl phthalate
  • HY-N1510
    Kaempferol 3-O-gentiobioside
    		Inhibitor 99.47%
    Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. Kaempferol 3-O-gentiobioside possesses activity against α-glucosidase and displays carbohydrate enzyme inhibitory effect with an IC50 of 50.0 µM.
    Kaempferol 3-O-gentiobioside
  • HY-113133
    Kojibiose
    		Inhibitor 99.76%
    Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo.
    Kojibiose
  • HY-101779
    DCG04
    		98.55%
    DCG04 is a multivalent ligand for the mannose-6-phosphate receptor. DCG-04 is an activity-based probe for cysteine cathepsins, and can be used for labelling numerous cysteine cathepsins in cell and tissue lysates.
    DCG04
  • HY-N4095
    Brevifolincarboxylic acid
    		Inhibitor 99.90%
    Brevifolincarboxylic acid is a phenolic compound. Brevifolincarboxylic acid can be isolated from Duchesnea chrysantha. Brevifolincarboxylic acid inhibits α-glucosidase with an IC50 value of 323.46 μM. Brevifolincarboxylic acid has an inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarbacid scavenges ROS. Brevifolincarbacid restores the glucose uptake activity of myotubes. Brevifolincarboxylic acid has antitumor activity against lung and gastric cancer. Brevifolincarbacid can be used in the study of diabetes and inflammatory diseases.
    Brevifolincarboxylic acid
  • HY-N2574
    Gitogenin
    		Inhibitor 99.82%
    Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms.
    Gitogenin
  • HY-N7203
    N-Caffeoyl O-methyltyramine
    		Inhibitor 98.44%
    N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase (IC50 of 103.58 μM).
    N-Caffeoyl O-methyltyramine
  • HY-120034
    NCGC 607
    		Modulator 99.53%
    NCGC 607 is a noninhibitory small-molecule chaperone of glucocerebrosidase (GCase). NCGC 607 can increase GCase activity, reduce α-synuclein levels, and decrease glycolipid levels. NCGC 607 can be used in the research of Gaucher disease and Parkinson's disease.
    NCGC 607
  • HY-121811
    Pongamol
    		Inhibitor 99.81%
    Pongamol (Lanceolatin C) is potent α-glucosidase inhibitor (IC50=103.5 μM) and has free-radical (DPPH) scavenging,antihyperglycemic, and antihyperglycemic activities.
    Pongamol
  • HY-N3431
    Kaempferol-7-O-rhamnoside
    		Inhibitor 99.18%
    Kaempferol-7-O-rhamnoside, isolated from Chimonanthus nitens Oliv. Leaves, is a potent α-glucosidase activity inhibitor. Kaempferol-7-O-rhamnoside has the potential for diabetes.
    Kaempferol-7-O-rhamnoside
  • HY-N2168
    Pinoresinol 4-O-β-D-glucopyranoside
    		Inhibitor 99.89%
    Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor, with an IC50 of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects.
    Pinoresinol 4-O-β-D-glucopyranoside
  • HY-16134A
    Celgosivir hydrochloride
    		Inhibitor ≥98.0%
    Celgosivir hydrochloride (MBI 3253 hydrochloride; MDL 28574 hydrochloride; MX3253 hydrochloride) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay.
    Celgosivir hydrochloride
  • HY-N4258
    Panasenoside
    		Inhibitor 99.93%
    Panasenoside is a flavonoid isolated from Lilium pumilum DC. Panasenoside exhibits α-glucosidase inhibitory activity.
    Panasenoside
  • HY-P990366
    Anti-CHI3L1 Antibody
    		Inhibitor 99.49%
    The Anti-CHI3L1 Antibody is a human antibody expressed in CHO that targets CHI3L1. The Anti-CHI3L1 Antibody contains huIgG1 type heavy chain and huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-CHI3L1 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CHI3L1 Antibody
  • HY-14829E
    Afegostat D-Tartrate
    		Inhibitor ≥98.0%
    Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.
    Afegostat D-Tartrate
  • HY-P2869A
    β1-3 Galactosidase
    β1-3 Galactosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal β1-3-linked galactose from oligosaccharides and glycoprotein substrates, at a much lower rate, β1-6 linked galactose residues from oligosaccharides.
    β1-3 Galactosidase
  • HY-B0089R
    Acarbose (Standard)
    		Inhibitor
    Acarbose (Standard) is the analytical standard of Acarbose. This product is intended for research and analytical applications. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin.
    Acarbose (Standard)
  • HY-156838
    Cyclophellitol aziridine
    		Inhibitor
    Cyclophellitol aziridine is a cyclophenol analogue and a potent β-glucosidase inhibitor.
    Cyclophellitol aziridine
  • HY-139663
    IHVR-17028
    		Inhibitor 99.61%
    IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC50 of 0.24 μM. IHVR-17028 can be used for infectious diseases research.
    IHVR-17028
  • HY-137490
    4-Methylumbelliferyl α-L-arabinofuranoside
    		99.93%
    4-Methylumbelliferyl α-L-arabinofuranoside is the glycosidase substrate.
    4-Methylumbelliferyl α-L-arabinofuranoside
Cat. No. Product Name / Synonyms Application Reactivity