2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glycosidase

Glycosidase

Glycosidase

Glycosidase

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Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N2469
    Xylotriose
    		Activator 99.38%
    Xylotriose is a natural xylooligosaccharide, acts as a bifidogenic factor.
    Xylotriose
  • HY-N2025
    Oroxin A
    		Inhibitor 99.76%
    Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence.
    Oroxin A
  • HY-137827
    4-Nitrophenyl β-D-Cellobioside
    		Substrate 99.48%
    4-Nitrophenyl β-D-Cellobioside (p-Nitrophenyl β-D-cellobioside) is a cellotriose analog. 4-Nitrophenyl β-D-Cellobioside is hydrolyzed by β-glucosidases such as TxGH116 and ThCel7B. 4-Nitrophenyl β-D-Cellobioside can also be hydrolyzed by exoglucanases and endoglucanases to produce p-nitrophenol (PNP). 4-Nitrophenyl β-D-Cellobioside can be used to detect cellulase activity.
    4-Nitrophenyl β-D-Cellobioside
  • HY-N1029
    Norathyriol
    		Inhibitor 99.74%
    Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.
    Norathyriol
  • HY-108903
    Hyaluronidase (human recombinant)
    Hyaluronidase (human recombinant) (Hylenex; Vorhyaluronidase alfa; rHuPH 20) is an enzyme that catalyzes the degradation of hyaluronic acid. Hyaluronidase (human recombinant) is used to improve the absorption and dispersal of parenteral fluids, medications, and contrast media.
    Hyaluronidase (human recombinant)
  • HY-D1878
    SPiDER-βGal-1
    		Substrate 99.39%
    SPiDER-βGal-1 is a fluorogenic β-galactosidase substrate and suitable for labeling live cells in culture and in living tissues. SPiDER-βGal-1 can generate quinone methide through enzymatic reaction and form covalent bonds with nucleophilic functional groups of proteins near the molecule, so that the fluorescent product is fixed in living cells (Ex/Em = 493, 525 nm/560 nm).
    SPiDER-βGal-1
  • HY-P2775
    β-Glucosidase, almond
    		Chemical
    β-Glucosidase, almond is the rate-limiting enzyme in cellulose degradation. β-Glucosidase is a major group among glycoside hydrolases. β-Glucosidase is involved in the degradation of cellulose in soils and has potential for monitoring soil quality.
    β-Glucosidase, almond
  • HY-163387
    CHI3L1-IN-1
    		Inhibitor 99.68%
    CHI3L1-IN-1 (Compound 30) is an inhibitor for Chitinase-3-like protein 1 (CHI3L1) (YKL-40) with IC50 of 50 nM. CHI3L1-IN-1 inhibits hERG channel with an IC50 of 2.3 μM.
    CHI3L1-IN-1
  • HY-N2230
    N-p-trans-Coumaroyltyramine
    		Inhibitor 99.28%
    N-p-trans-Coumaroyltyramine is a natural phenolic amide compound and an inhibitor of AChE (IC50: 122 μM) and α-glucosidase (IC50: 2.7 μM). N-p-trans-Coumaroyltyramine also has anti-trypanosomal activity, with an IC50 of 13.3 µM against T. brucei rhodesiense. N-p-trans-Coumaroyltyramine can be used in the research of diseases such as Alzheimer's disease.
    N-p-trans-Coumaroyltyramine
  • HY-14860A
    1-Deoxynojirimycin hydrochloride
    		Inhibitor ≥98.0%
    1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features.
    1-Deoxynojirimycin hydrochloride
  • HY-W002011
    Quinoline-2-carboxylic acid
    		Inhibitor 99.94%
    Quinoline-2-carboxylic acid exhibits antidiabetic activity. Quinoline-2-carboxylic acid can be used as drug intermediate for synthesis of various active compounds.
    Quinoline-2-carboxylic acid
  • HY-N0346A
    (E)-Ethyl p-methoxycinnamate
    		Inhibitor 99.53%
    (E)-Ethyl p-methoxycinnamate is a natural product found in Kaempferia galangal with anti-inflammatory, anti-neoplastic and anti-microbial effects. (E)-Ethyl p-methoxycinnamate inhibits COX-1 and COX-2 in vitro with IC50s of 1.12 and 0.83 μM, respectively.
    (E)-Ethyl p-methoxycinnamate
  • HY-N4195
    Resveratroloside
    		Inhibitor 99.88%
    Resveratroloside (Resveratrol glycoside) is an orally active competitive inhibitor of α-glucosidase. Resveratroloside has hypoglycemic and cardioprotective effects. Resveratroloside can be used for the research of diabetes and heart system diseases.
    Resveratroloside
  • HY-107532
    N-Nonyldeoxynojirimycin
    		Inhibitor ≥99.0%
    N-Nonyldeoxynojirimycin (NN-DNJ) is a deoxynojirimycin derivative with a hydrophobic long chain. N-Nonyldeoxynojirimycin is an orally active inhibitor of acid α-glucosidase (IC50: 0.42 μM) and α-1,6-glucosidase (IC50: 8.4 μM). N-Nonyldeoxynojirimycin has activities of inhibiting glycogen breakdown, anti-virus and anti-tumor. N-Nonyldeoxynojirimycin also has insecticidal effects, with an LD50 of 5 mM for adults of Bemisia tabaci.
    N-Nonyldeoxynojirimycin
  • HY-N2278
    Kushenol A
    		Inhibitor 99.98%
    Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging.
    Kushenol A
  • HY-N3962
    Glycyrrhisoflavone
    		Inhibitor 99.43%
    Glycyrrhisoflavone, an active prenylflavonoid, inhibits α-glucosidase.
    Glycyrrhisoflavone
  • HY-W009417
    Cedryl acetate
    		Inhibitor 99.78%
    Cedryl acetate is a tricyclic sesquiterpene isolated from the plant Cunninghamia lanceolata. Cedryl acetate shows α-glucosidase inhibitory activity.
    Cedryl acetate
  • HY-N3405
    Lariciresinol
    		Inhibitor 99.79%
    Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity (IC50 of 6.97 μM; Ki of 0.046 μM). Lariciresinol dereases Bcl-2, upregulates Bax and induces Apoptosis. Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity.
    Lariciresinol
  • HY-N9317
    Tangshenoside I
    		Inhibitor 99.02%
    Tangshenoside I, isolated from the roots of Codonopsis lanceolata, exhibits weak α-glucosidase inhibitory activities in vitro with an IC50 of 1.4 mM.
    Tangshenoside I
  • HY-N0374
    Licochalcone C
    		Inhibitor 99.55%
    Licochalcone C could inhibit α-glucosidase, with IC50s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively.
    Licochalcone C
Cat. No. Product Name / Synonyms Application Reactivity