2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14789
    Amidomycin
    		Inhibitor
    Amidomycin is an antibiotic active primarily against yeast.
    Amidomycin
  • HY-N14254
    Hypelcin A-Ⅰ
    		Inhibitor
    Hypelcin A-I has anti-Gram-negative bacterial and fungal activity.
    Hypelcin A-Ⅰ
  • HY-N0756AR
    (-)-Bornyl acetate (Standard)
    		Inhibitor
    (-)-Bornyl acetate (Standard) is the analytical standard of (-)-Bornyl acetate. This product is intended for research and analytical applications. (-)-Bornyl acetate (L-(-)-Bornyl acetate), isolated from hyssop oil, is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate possesses antifungal activity.
    (-)-Bornyl acetate (Standard)
  • HY-N14027
    Chondramide B
    		Inhibitor
    Chondramide B has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities.
    Chondramide B
  • HY-N7093R
    Furaneol (Standard)
    		Inhibitor
    Furaneol (Standard) is the analytical standard of Furaneol. This product is intended for research and analytical applications. Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines.
    Furaneol (Standard)
  • HY-W714837
    5-Phenyllevulinic acid
    		Inhibitor
    5-Phenyllevulinic acid (4-Oxo-5-phenylpentanoic acid) is an endogenous fungal metabolite with inhibitory activity against the bacterium B. megaterium, the plant pathogenic fungus S. tritici, and the alga C. fusca. 5-Phenyllevulinic acid is also an intermediate in the synthesis of σ receptor ligands. 5-Phenyllevulinic acid holds potential for research in the field of anti-infection studies .
    5-Phenyllevulinic acid
  • HY-121245
    Capoamycin
    		Inhibitor
    Capoamycin is an antibiotic. Capoamycin shows antimicrobial and antitumor activity.
    Capoamycin
  • HY-B0842R
    Thiophanate-Methyl (Standard)
    		Inhibitor
    Thiophanate-Methyl (Standard) is the analytical standard of Thiophanate-Methyl. This product is intended for research and analytical applications. Thiophanate-Methyl is a systematic fungicide.
    Thiophanate-Methyl (Standard)
  • HY-17643R
    Oteseconazole (Standard)
    		Inhibitor
    Oteseconazole (Standard) is the analytical standard of Oteseconazole. This product is intended for research and analytical applications. Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candida albicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes.
    Oteseconazole (Standard)
  • HY-172676
    GW461484A
    		Inhibitor
    GW461484A is a small-molecule inhibitor targeting Candida albicans Yck2, with an IC50 of 0.11 µM. It exhibits antifungal activity against C. albicans with a MIC80 of 12.5 µM. GW461484A holds potential for research on fungal diseases, such as drug-resistant Candida infections.
    GW461484A
  • HY-N12676
    Phoslactomycin E
    		Inhibitor
    Phoslactomycin E has weak effect against Gram-positive bacteria, but has strong effect against fungi.
    Phoslactomycin E
  • HY-P5590
    Dermaseptin-S3
    		Inhibitor
    Dermaseptin-S3 is an antimicrobial peptide derived from frog skin against filamentous fungi.
    Dermaseptin-S3
  • HY-17381R
    Idarubicin hydrochloride (Standard)
    		Inhibitor
    Idarubicin (hydrochloride) (Standard) is the analytical standard of Idarubicin (hydrochloride). This product is intended for research and analytical applications. Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.
    Idarubicin hydrochloride (Standard)
  • HY-B0319R
    Tioconazole (Standard)
    		Inhibitor
    Tioconazole (Standard) is the analytical standard of Tioconazole. This product is intended for research and analytical applications. Tioconazole (UK-20349) is an antifungal imidazole derivative with broad spectrum activity. Tioconazole has inhibitory active aginst several dermatophytes and several yeasts with MIC50s <3.12 mg/L and <9 mg/L, respectively.
    Tioconazole (Standard)
  • HY-W021040S
    Fludioxonil-13C3
    		Inhibitor
    Fludioxonil-13C3 (CGA-173506-13C3) is 13C labeled Fludioxonil. Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells.
    Fludioxonil-<sup>13</sup>C<sub>3</sub>
  • HY-N14716
    Haematocin
    		Inhibitor
    Haematocin can inhibit the germination of Pyricularia oryzae spore.
    Haematocin
  • HY-P5593
    Dermaseptin-S2
    		Inhibitor
    Dermaseptin-S2 is an antimicrobial peptide derived from frog skin against filamentous fungi.
    Dermaseptin-S2
  • HY-B1134R
    Imazalil (Standard)
    		Inhibitor
    Imazalil (Standard) is the analytical standard of Imazalil. This product is intended for research and analytical applications. Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder.
    Imazalil (Standard)
  • HY-168998
    Yck2-IN-1
    		Inhibitor
    Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC50 of approximately 80 nM against Yck2 and a MIC80 of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes). In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection.
    Yck2-IN-1
  • HY-116857
    Ditalimfos
    Ditalimfos is an organophosphate fungicide. Ditalimfos is mainly used in agriculture to control fungal diseases of crops. Ditalimfos can be used for fungal resistance studies and risk assessment of residues in the environment.
    Ditalimfos
Cat. No. Product Name / Synonyms Application Reactivity