2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14810
    Neobulgarone D
    		Inhibitor
    Neobulgarone D is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone D can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone D
  • HY-W473763
    3-Methoxy-2,5-toluquinone
    		Inhibitor
    3-Methoxy-2, 5-toluquinone is an antibacterial agent with moderate anti-bacterial and fungal effects.
    3-Methoxy-2,5-toluquinone
  • HY-136756
    CYP51-IN-6
    		Inhibitor
    CYP51-IN-2 (compound 1f), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 15.6 ng/mL for Microsporum gypseum and Candida albicans, respectively.
    CYP51-IN-6
  • HY-N14329
    Maniwamycin B
    		Inhibitor
    Maniwamycin B has anti-fungal effect.
    Maniwamycin B
  • HY-W983893
    7-Hydroxytropolone
    		Inhibitor
    7-Hydroxytropolone (3-Hydroxytropolone) is an antibiotic with anti-Gram-positive bacteria, negative bacteria, yeast and fungi activity, and has the effect of inhibiting 2''-O-Adenylyltransferase.
    7-Hydroxytropolone
  • HY-114927
    (±)-Dunnione
    		Inhibitor
    (±)-Dunnione (SL 11010) is a compound with broad-spectrum antifungal activity that acts by initiating redox cycling.
    (±)-Dunnione
  • HY-176417
    Antifungal agent 132
    		Inhibitor
    Antifungal agent 132 (compound 25) is a selective and potent antifungal agent. Antifungal agent 132 inhibits Cryptococcus neoformans May1 with a Ki of 180 pM.
    Antifungal agent 132
  • HY-113219R
    Hydroxyphenyllactic acid (Standard)
    		Inhibitor
    Hydroxyphenyllactic acid (Standard) is the analytical standard of Hydroxyphenyllactic acid. This product is intended for research and analytical applications. Hydroxyphenyllactic acid is an antifungal metabolite.
    Hydroxyphenyllactic acid (Standard)
  • HY-157027
    Antifungal agent 85
    		Inhibitor
    Antifungal agent 85 (compound 24f) is a potent antibacterial compound with the minimum inhibitory concentration (MIC) values between 2.5 and 10 μM against various Gram-positive bacteria.
    Antifungal agent 85
  • HY-122451R
    Ofurace (Standard)
    		Inhibitor
    Ofurace (Standard) is the analytical standard of Ofurace. This product is intended for research and analytical applications. Ofurace is a fungicide that is extremely active against Pythium ultima, Phytophthora tabacum and Phytophthora palmi. Ofurace has a greater effect on sporangia formation than on mycelium growth.
    Ofurace (Standard)
  • HY-N12680
    Phoslactomycin B
    		Inhibitor
    Phoslactomycin B has weak effect against Gram-positive bacteria, but has strong effect against fungi.
    Phoslactomycin B
  • HY-N14150
    Darlucin A
    		Inhibitor
    Darlucin A has antibacterial and fungi activity, and weak cytotoxicity.
    Darlucin A
  • HY-129234
    Mazethramycin
    		Inhibitor
    Mazethramycin is an antitumor antibiotic that exerts its antitumor effect by interfering with cellular DNA replication and RNA synthesis. Mazethramycin can be used in cancer research.
    Mazethramycin
  • HY-165154
    Cyclamidomycin
    		Inhibitor
    Cyclamidomycin (Desdanine) is an acrylamide antibiotic with antibacterial activity. Cyclamidomycin inhibits nucleoside diphosphate kinase and pyruvate kinase (in E. coli) and oxidative phosphorylation in rat liver mitochondria. Cyclamidomycin is active against S. aureus, M. flavus, S. lutea, B. subtilis, E. coli, S. flexneri, S. typhosa, P. vulgaris, and K. pneumoniae (MICs=3.12-25 mg/ml).
    Cyclamidomycin
  • HY-N14408
    Fosfazinomycin B
    		Inhibitor
    Fosfazinomycin B has the activity of resisting plant pathogenic fungi such as Xanthomonas oryzae.
    Fosfazinomycin B
  • HY-N14266
    Hypelcin A-IV
    		Inhibitor
    Hypelcin A-IV has anti-Gram-negative bacterial and fungal activity.
    Hypelcin A-IV
  • HY-B1975R
    Dithianon (Standard)
    		Inhibitor
    Dithianon (Standard) is the analytical standard of Dithianon. This product is intended for research and analytical applications. Dithianon is a broad-spectrum anthraquinone fungicide with good adherence to the surface of leaves and fruits. Dithianon is used to control several several fungal of some fruits and vegetables, as anthracnose (Colletotrichum sp., Elsinoe ampelina), mildew (Plasmopara viticola), phomopsis (Phomopsis viticola), among others.
    Dithianon (Standard)
  • HY-131050
    Aspergillus niger-IN-1
    		Inhibitor
    Aspergillus niger-IN-1 (Compound 17), a derivative of thiazolidine-2,4-dione, acts as an antimicrobial agent. Aspergillus niger-IN-1 exhibited antimicrobial activity against various bacterial and fungal strains, including Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli, Salmonella typhi, Candida albicans and Aspergillus niger, with MIC values of 11.3, 5.65, 11.3, 5.65, 5.65, 5.65, and 5.65 μM/mL, respectively .
    Aspergillus niger-IN-1
  • HY-N13963
    Bagremycin B
    		Inhibitor
    Bagremycin B is found in the strain of Streptomyce sp. Tu 4128. Bagremycin B has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candida albicans.
    Bagremycin B
  • HY-P5705
    Gageotetrin B
    		Inhibitor
    Gageotetrin B has antimicrobial activities. Gageotetrin B is more active against fungi compared to bacteria with MIC values of 0.01-0.04 μM.
    Gageotetrin B
Cat. No. Product Name / Synonyms Application Reactivity