2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-170816
    CYP51/Hsp90-IN-1
    		Inhibitor
    CYP51/Hsp90-IN-1 (Compound MM4) is a dual CYP51/Hsp90 inhibitor. CYP51/Hsp90-IN-1 shows antifungal activity against Candida albicans and effectively inhibits important fungal virulence factors. CYP51/Hsp90-IN-1 is promising for research of invasive candidiasis.
    CYP51/Hsp90-IN-1
  • HY-B2148R
    Myclobutanil (Standard)
    		Inhibitor
    Myclobutanil (Standard) is the analytical standard of Myclobutanil. This product is intended for research and analytical applications. Myclobutanil is a conazole class fungicide widely used as an agrichemical.
    Myclobutanil (Standard)
  • HY-136762
    CYP51-IN-12
    		Inhibitor
    CYP51-IN-2 (compound 1l), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 15.6 ng/mL for Microsporum gypseum and Candida albicans.
    CYP51-IN-12
  • HY-119465
    Restricticin
    Restricticin is a compound obtained from marine fungi, whose structure contains alkene, tetrahydropyran ring and glycine ester functional groups, and has anti-neuroinflammatory effects in lipopolysaccharide-induced BV-2 microglia by inhibiting the production of proinflammatory mediators.
    Restricticin
  • HY-17373A
    Posaconazole hydrate
    		Inhibitor
    Posaconazole hydrate is a broad-spectrum, second generation, triazole compound with antifungal activity.
    Posaconazole hydrate
  • HY-P5588
    Dermaseptin-S4
    		Inhibitor
    Dermaseptin-S4 is an antimicrobial peptide derived from frog skin against filamentous fungi.
    Dermaseptin-S4
  • HY-N8519
    Urdamycin B
    		Inhibitor
    Urdamycin B is an antibiotic that effectively inhibits fungi and bacteria. Urdamycin B also exhibits anti-proliferative activity against mouse leukemia cells L1210. Urdamycin B can be obtained from the metabolic products of Streptomyces fradiae. Urdamycin B can be used for research on cancer as well as bacterial and fungal infections.
    Urdamycin B
  • HY-W020183R
    γ-Terpinene (Standard)
    		Inhibitor
    γ-Terpinene (Standard) is the analytical standard of γ-Terpinene. This product is intended for research and analytical applications. γ-Terpinene, a monoterpene, is an orally active antioxidant compound which can scavenge radicals directly. γ-Terpinene has potent antinociception activity. γ-Terpinene exhibits antimicrobial efficacy against various bacteria and fungi.
    γ-Terpinene (Standard)
  • HY-N14444
    Haliangicin D
    		Inhibitor
    Haliangicin D has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
    Haliangicin D
  • HY-130317
    trans-11-Methyl-2-dodecenic acid
    trans-11-Methyl-2-dodecenic acid is a isomer of cis-11-Methyl-2-dodecenoic acid (HY-134215). cis-11-Methyl-2-dodecenoic acid is a quorum sensing (QS) signal that acts as a diffusion signaling factor (DSF) in extracellular microbial and fungal communication systems.
    trans-11-Methyl-2-dodecenic acid
  • HY-170616
    JH-FK-08
    		Inhibitor
    JH-FK-08 is an inhibitor for the serine/threonine-specific phosphatase calcineurin. JH-FK-08 exhibits antifungal activity that inhibits C. neoformans with MIC80 of 0.8 µg/mL. JH-FK-08 exhibits immunosuppressive activity and inhibits the IL-2 expression with an IC50 of 42.6 nM. JH-FK-08 exhibits anti-infectious activity in mouse models.
    JH-FK-08
  • HY-W103183R
    Ferron (Standard)
    		Inhibitor
    Ferron (Standard) is the analytical standard of Ferron. This product is intended for research and analytical applications. Ferron (8-Hydroxy-7-iodo-5-quinolinesulfonic acid) has antiseptic and antifungal activity. Ferron can prevent skin and mucosa bacterial irritations and inflammations.
    Ferron (Standard)
  • HY-B0843R
    Metalaxyl (Standard)
    		Inhibitor
    Metalaxyl (Standard) is the analytical standard of Metalaxyl. This product is intended for research and analytical applications. Metalaxyl is a fungicide agent that inhibits the protein synthesis in fungi. Metalaxyl against downy mildews and soil-borne diseases by Phytium ssp. and Phytophthora ssp..
    Metalaxyl (Standard)
  • HY-135549R
    Fluxapyroxad (Standard)
    		Inhibitor
    Fluxapyroxad (Standard) is the analytical standard of Fluxapyroxad. This product is intended for research and analytical applications. Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. It works by inhibiting succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species.
    Fluxapyroxad (Standard)
  • HY-N3041
    Plumieride
    		Inhibitor
    Plumieride is an antifungal agent. Plumieride has strong fungitoxicity against some dermatophytes. Plumieride has little cytotoxic activity against the P388 leukaemia cell line with an IC50 of 85 μg/mL.
    Plumieride
  • HY-17514R
    Itraconazole (Standard)
    		Inhibitor
    Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
    Itraconazole (Standard)
  • HY-N7364S
    (E)-β-Farnesene-d6
    		Inhibitor
    (E)-β-Farnesene-d6 is deuterated labeled (E)-β-Farnesene (HY-N7364). (E)-β-Farnesene (trans-β-Farnesene) is an aphid alarm pheromone, which can be found in Phlomis aurea Decne essential oil. (E)-β-Farnesene shows good binding score with a value of -30.64 kcal/mol to the CDK2 receptor. (E)-β-Farnesene also exhibits good affinity to odorant-binding protein 3 (OBP3). (E)-β-Farnesene can be used as a feeding stimulant for the sand fly Lutzomyia longipalpis.
    (E)-β-Farnesene-d<sub>6</sub>
  • HY-117496
    Ampelopsin A
    		Inhibitor
    Ampelopsin A is a antifungal agent and can be isolated from the Vitis vinifera canes. Ampelopsin A shows neuroprotective effects.
    Ampelopsin A
  • HY-N8015S2
    Octanal-d4
    		Inhibitor
    Octanal-d4 is deuterated labeled Octanal (HY-N8015). Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC50 value of 3.5 μg/mL.
    Octanal-d<sub>4</sub>
  • HY-B0845R
    Prochloraz (Standard)
    		Inhibitor
    Prochloraz (Standard) is the analytical standard of Prochloraz. This product is intended for research and analytical applications. Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM.
    Prochloraz (Standard)
Cat. No. Product Name / Synonyms Application Reactivity