2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-135480
    Geninthiocin
    		Inhibitor
    Geninthiocin is a thiopeptide with antibacterial and antifungal activities. Geninthiocin is a tipA promoter.
    Geninthiocin
  • HY-N12118
    Piperanine
    		Inhibitor
    Piperanine is an antifungal agent. Piperanine shows growth inhibition against the fungus Cladosporium claspoirioides. Piperanine can be isolated from the fruits of Piper retrofractum.
    Piperanine
  • HY-N14037
    Chondramide C
    		Inhibitor
    Chondramide C has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities.
    Chondramide C
  • HY-121461
    A25822B
    		Inhibitor
    A25822B is an antifungal agent, with a MIC of 1 μM for Ascosphaera apis. A25822B causes conformational changes in mitochondria and disruption of spore membrane structure. A25822B can be used for the research of bee chalk disease.
    A25822B
  • HY-N0535R
    (+)-Magnoflorine chloride (Standard)
    		Inhibitor
    (+)-Magnoflorine (chloride) (Standard) is the analytical standard of (+)-Magnoflorine (chloride). This product is intended for research and analytical applications. Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm. Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity.
    (+)-Magnoflorine chloride (Standard)
  • HY-13553R
    Anidulafungin (Standard)
    		Inhibitor
    Anidulafungin (Standard) is the analytical standard of Anidulafungin. This product is intended for research and analytical applications. Anidulafungin is a new semisynthetic echinocandin with antifungal potency.
    Anidulafungin (Standard)
  • HY-116631
    Sarisan
    		Inhibitor
    Sarisan (Asaricin) is a phenolic derivative with antifungal and insecticidal activity. Sarisan can be found in the stem bark of Ocotea opifera Mart..
    Sarisan
  • HY-13553S1
    Anidulafungin-13C6
    		Inhibitor
    Anidulafungin-13C6 (LY303366-13C6) is 13C labeled Anidulafungin. Anidulafungin is a new semisynthetic echinocandin with antifungal potency.
    Anidulafungin-<sup>13</sup>C<sub>6</sub>
  • HY-N14526
    Octacosamicin A
    		Inhibitor
    Octacosamicin A has the function of resisting bacterium, yeast, and filamentous fungus, but the function of resisting bacterium is weak.
    Octacosamicin A
  • HY-124508
    Lambertellin
    		Inhibitor
    Lambertellin is an effective antibiotic that can be used as a bactericide and as a fungicide. Lambertellin exerts its anti-inflammatory effect in LPS (HY-D1056)-stimulated RAW 264.7 macrophage cells by modulating the activation of the MAPK and NF-κB signaling pathways.
    Lambertellin
  • HY-N14898
    Oudermansin B
    		Inhibitor
    Oudermansin B is an antibiotic. Oudermansin B acts on fungi to inhibit protein, RNA and DNA synthesis.
    Oudermansin B
  • HY-N14750
    Emimycin
    		Inhibitor
    Emimycin has anti-Gram-positive bacteria, negative bacteria and brewer's yeast and other fungal activities.
    Emimycin
  • HY-125776R
    Kresoxim-methyl (Standard)
    		Inhibitor
    Kresoxim-methyl (Standard) is the analytical standard of Kresoxim-methyl. This product is intended for research and analytical applications. Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme.
    Kresoxim-methyl (Standard)
  • HY-173490
    Antifungal agent 131
    		Inhibitor
    Antifungal agent 131 (compound A20) is an antifungal compound with a minimum inhibitory concentration (MIC) of 64 μg/mL. Antifungal agent 131 demonstrates excellent antifungal potential when used in combination with Fluconazole (HY-B0101).
    Antifungal agent 131
  • HY-N15012
    6-O-Demethyl-5-deoxyfusarubin
    		Inhibitor
    6-O-Demethyl-5-deoxyfusarubin has the ability of anti-fungal and mycoplasma.
    6-O-Demethyl-5-deoxyfusarubin
  • HY-N15320
    Schidigera-genin B
    		Inhibitor
    Schidigera-genin B is a steroidal sapogenin that can be isolated from Yucca glauca. Schidigera-genin B exhibits weak antifungal activity.
    Schidigera-genin B
  • HY-B0454R
    Miconazole (Standard)
    		Inhibitor
    Miconazole (Standard) is the analytical standard of Miconazole. This product is intended for research and analytical applications. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects.
    Miconazole (Standard)
  • HY-N14111
    Cuevaene A
    		Inhibitor
    Cuevaene A can be isolated from the strain of gdmAI-disrupted Streptomyces sp. LZ35 and. Cuevaene A displays moderate activity against Gram-positive bacteria (e.g., Bacillus subtilis strain ATCC 11060) and modest activity against fungi (e.g., Fusarium verticillioides strain S68 and Rhizoctonia solani strain GXE4).
    Cuevaene A
  • HY-N12679
    Phoslactomycin D
    		Inhibitor
    Phoslactomycin D has weak effect against Gram-positive bacteria, but has strong effect against fungi.
    Phoslactomycin D
  • HY-136759
    CYP51-IN-9
    		Inhibitor
    CYP51-IN-2 (compound 1i), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 62.5 for Microsporum gypseum and Candida albicans.
    CYP51-IN-9
Cat. No. Product Name / Synonyms Application Reactivity