2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W774918
    Oxaziclomefone
    		Inhibitor
    Oxaziclomefone is a broad-spectrum pesticide with fungal activity. Oxaziclomefone effectively controls a variety of crop diseases and has significant effects against plant pathogenic fungi. Oxaziclomefone is widely used in agriculture to protect crops from diseases and improve crop yield and quality.
    Oxaziclomefone
  • HY-149738
    FXh
    		Inhibitor
    FXh is a functionalized hapten activated by incubation with N, N′-disuccinimidyl carbonate, and Et3N in acetonitrile at 0 °C. FXh can improve the affinity of antigens.
    FXh
  • HY-120729R
    Pyrazophos (Standard)
    		Inhibitor
    Pyrazophos (Standard) is the analytical standard of Pyrazophos. This product is intended for research and analytical applications. Pyrazophos (Curamil) is a slightly systemic fungicide against the powdery mildew on crops and cereals. Pyrazophos is widely used in Greece to control diseases caused by Erysiphe spp., Sphaerotheca spp., Leveillula spp. and Oidium spp..
    Pyrazophos (Standard)
  • HY-N7237
    Stichloroside B1
    		Inhibitor
    Stichloroside B1 is a class of antifungal triterpenoid oligosaccharide isolated from the sea cucumber Stichopus chloronotus (BRANDT).
    Stichloroside B1
  • HY-116686
    Inz-1
    		Inhibitor
    Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans.
    Inz-1
  • HY-P5729
    LL-25
    		Inhibitor
    LL-25 is a fragment of LL-37 (HY-P1222) but devoid of the immunomodulatory properties of LL-37. LL-25 has antifungal and candidacidal activity.
    LL-25
  • HY-135761S
    Penconazole-d7
    		99.17%
    Penconazole-d7 is the deuterium labeled Penconazole. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.
    Penconazole-d<sub>7</sub>
  • HY-N13873
    Saricandin
    Saricandin has weak antifungal activity. Saricandin inhibits glucan synthase with an ID50 of 242.0 μg/mL.
    Saricandin
  • HY-N14746
    Elizabethin
    		Inhibitor
    Elizabethin has antifungal activity.
    Elizabethin
  • HY-111912R
    Tribenuron-methyl (Standard)
    		Inhibitor
    Tribenuron-methyl (Standard) is the analytical standard of Tribenuron-methyl. This product is intended for research and analytical applications. Tribenuron-methyl, a sulfonylurea herbicide agent, can be used as the fungicide agent. Tribenuron-methyl plays an important role in controlling the weeds and diseases in wheat field.
    Tribenuron-methyl (Standard)
  • HY-N14968
    Enniatin F
    		Inhibitor
    Enniatin F has insecticidal and antifungal activity. Enniatin F also can inhibit acyl-CoA, cholesterol acyltransferase (ACAT).
    Enniatin F
  • HY-B2056R
    Triforine (Standard)
    		Inhibitor
    Triforine (Standard) is the analytical standard of Triforine. This product is intended for research and analytical applications. Triforine (CELA W 524), a systemic fungicide, was shown to display a moderate to distinct fungitoxic activity in vitro towards several pathogenic and non-pathogenic fungi.
    Triforine (Standard)
  • HY-N14199
    Mathemycin B
    		Inhibitor
    Mathemycin B has an inhibitory effect on pathogenic fungi. Mathemycin B inhibits the Phytophthora infestans JO8 in vitro (MIC is 7.8 μg/mL).
    Mathemycin B
  • HY-B0914AR
    10-Undecenoic acid zinc salt (Standard)
    		Inhibitor
    10-Undecenoic acid (zinc salt) (Standard) is the analytical standard of 10-Undecenoic acid (zinc salt). This product is intended for research and analytical applications. 10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa.
    10-Undecenoic acid zinc salt (Standard)
  • HY-137085
    Antibiotic AB023b
    		Inhibitor
    Antibiotic AB023b is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023a (HY-137084). Antibiotic AB023b exhibits antifungal activity against Candida albicans, and plant pathogenic fungi, Botrytis cinerea, Fusarium moniliforme and Pythium ultimum.
    Antibiotic AB023b
  • HY-W016806R
    Sodium methylparaben, 99% (Standard)
    		Inhibitor
    Sodium methylparaben, 99% (Standard) is the analytical standard of Sodium methylparaben, 99%. This product is intended for research and analytical applications. Sodium methylparaben, 99% (Sodium methyl 4-hydroxybenzoate, 99%) is an antifungal agent.
    Sodium methylparaben, 99% (Standard)
  • HY-N14821
    Neoenactin B1
    		Inhibitor
    Neoenactin B1 has strong anti-yeastlike and filamentous fungal effects.
    Neoenactin B1
  • HY-118580
    RO-09-4609
    		Inhibitor
    RO-09-4609 exhibits antimicrobial activity, that inhibits Candida albicans, Trypanosoma brucei and Plasmodium vivax through inhibition of N-myristoyl transferase.
    RO-09-4609
  • HY-162559
    SDH-IN-16
    		Inhibitor
    SDH-IN-16 (compound 5aa) is a potent inhibitor of Succinate Dehydrogenase, with the IC50 of 1.62 μM. SDH-IN-16 displays a broad spectrum of antifungal activity against F. graminearum, B. cinerea, S. sclerotiorum, and R. solani, with the corresponding EC50 values of 0.12, 4.48, 0.33, and 0.15 μg/mL, respectively.
    SDH-IN-16
  • HY-B0935R
    Benzyl benzoate (Standard)
    		Inhibitor
    Benzyl benzoate (Standard) is the analytical standard of Benzyl benzoate. This product is intended for research and analytical applications. Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC50= 0.06 g/m2) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry.
    Benzyl benzoate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity