2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-105110
    SCH 39304
    		Inhibitor
    SM-8668 is an effective orally active antifungal agent, with median effective doses (ED50) of 0.18, 3.7, and 5.9 mg/kg for systemic candidiasis, aspergillosis, and cryptococcosis in mice, respectively. Pharmacokinetic studies in mice and rats indicate that SM-8668 has a long half-life and a high total exposure. SM-8668 can be used in anti-infective research.
    SCH 39304
  • HY-131051
    Antimicrobial agent-41
    		Inhibitor
    Antimicrobial agent-41 (Compound 19) is a thiazolidinedione derivative. Antimicrobial agent-41 exhibits excellent antioxidant activity (IC50 = 27.66 μg/mL). Antimicrobial agent-41 also exhibits antidiabetic activity (IC50 = 40.01 μg/mL). Antimicrobial agent-41 has antimicrobial activity again both bacterial and fungi.
    Antimicrobial agent-41
  • HY-N0570R
    Hydroxytyrosol (Standard)
    		Inhibitor
    Hydroxytyrosol (Standard) is the analytical standard of Hydroxytyrosol. This product is intended for research and analytical applications. Hydroxytyrosol (DOPET) is a phenolic compound with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects.
    Hydroxytyrosol (Standard)
  • HY-167879A
    NPD6433
    		Inhibitor
    NPD6433 is a triazenyl indole with broad-spectrum activity against all screening fungal strains. NPD6433 targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH-oxidation activity and arresting essential fatty acid biosynthesis.
    NPD6433
  • HY-B2026S
    Propamocarb-d7
    Propamocarb-d7 is the deuterium labeled Propamocarb. Propamocarb is a systemic fungicide. Propamocarb is widely used to protect cucumbers, tomatoes and other plants from pathogens.
    Propamocarb-d<sub>7</sub>
  • HY-130772
    Filipin II
    		Inhibitor
    Filipin II is an antibiotic, which exhibits antifungal efficacy. Filipin II interacts with membrane sterols, leads to changes in membrane structure, inhibits Candida utilis and Saccharomyces cerevisiae with the MIC of 0.03 mg/L and 0.2 μg/L.
    Filipin II
  • HY-N14487
    Nemotin
    		Inhibitor
    Nemotin has the activity against Gram-positive bacteria, mycobacterium and fungus, and also against Gram-negative bacteria, but the activity is weak.
    Nemotin
  • HY-N15350
    Demethylblasticidin S
    		Inhibitor
    Demethylblasticidin S is an antifungal antibiotic that can be synthesized by Streptomyces griseochromogenes.
    Demethylblasticidin S
  • HY-N14985
    Dictyopanine A
    		Inhibitor
    Dictyopanine A is found in the strain of Dictylpanus sp. Hki 0181. The antibacterial spectrum is narrow, and it has moderate antibacterial activity only against some filamentous fungi and Gram-positive bacteria.
    Dictyopanine A
  • HY-N14685
    Heptaibin
    		Inhibitor
    Heptaibin is a peptaibol antifungal antibiotic. Heptaibin has the activity against Gram-positive bacteria (MIC is 8 μg/mL) such as Staphylococcus aureus and fungi (MIC is 13-32 μg/mL) such as Aspergillus, Candida albicans and cryptococcus neofordii, and it has moderate anti-Rhabditella pseudoelongata activity (MIC is 50 μg/mL).
    Heptaibin
  • HY-N14122
    Cladosporide B
    		Inhibitor
    Cladosporide B is found in the strain of Cladosporium sp. IFM 49189. Cladosporide B has slightly stronger anti-Aspergillus fumigatus activity than Cladosporide A.
    Cladosporide B
  • HY-N15048
    Phellinsin
    		Inhibitor
    Phellinsin selectively inhibits the activity of the chitin synthase I and II with IC50s (μg/mL) of 76 and 28, respectively. Phellinsin has the antifungal activity on Colletotrichum lagenarium, Pyricularia oryzae, Aspergillus fumigatus and Trichophyton mentagrophytes and so on (MIC is 12.5-50 μg/mL).
    Phellinsin
  • HY-N14172
    Epicorazine B
    		Inhibitor
    Epicorazine B has activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE), MICs of 12.5-25 μg/mL. Epicorazine B also has effect on Candida albicans with a MIC of 25 μg/mL.
    Epicorazine B
  • HY-N14208
    Polyoxin E
    		Inhibitor
    Polyoxin E is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin E
  • HY-N12683
    Phaseollinisoflavan
    		Inhibitor
    Phaseollinisoflavan, an antifungal isoflavonoid, is a phytoalexin.
    Phaseollinisoflavan
  • HY-109040R
    Quilseconazole (Standard)
    		Inhibitor
    Quilseconazole (Standard) is the analytical standard of Quilseconazole (HY-109040). This product is intended for research and analytical applications. Quilseconazole (VT-1129) is an orally active, highly selective fungal cytochrome P450 enzyme Cyp51 inhibitor that can cross the blood-brain barrier. Quilseconazole prevents the synthesis of ergosterol, an important component of the fungal cell membrane, by inhibiting Cyp51. Quilseconazole has minimal effects on human CYP enzymes. Quilseconazole has antifungal activity and can be used in the study of cryptococcal meningitis and other diseases.
    Quilseconazole (Standard)
  • HY-169551
    ATPase-IN-5
    ATPase-IN-5 (compound 11) is a potent inhibitor of Pma1p-ATPase, with the IC50 of 12.7 μM. ATPase-IN-5 plays an important role in anti-fungal research.
    ATPase-IN-5
  • HY-17395AR
    Terbinafine (Standard)
    		Inhibitor
    Terbinafine (Standard) is the analytical standard of Terbinafine. This product is intended for research and analytical applications. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Terbinafine (Standard)
  • HY-N14260
    Hypelcin A-II
    		Inhibitor
    Hypelcin A-II has anti-Gram-negative bacterial and fungal activity.
    Hypelcin A-II
  • HY-N15326
    Phytoalexine
    		Inhibitor
    Phytoalexine (Compound 8) is a phytoalexin found in wasabi with antifungal activity against fungi such as Phoma lingam and Phoma wasabiae. Phytoalexine inhibits spore germination and mycelial growth of fungi. Phytoalexine is promising for research of pesticides against plant fungal diseases.
    Phytoalexine
Cat. No. Product Name / Synonyms Application Reactivity