2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14956
    Fulvoferruginin
    		Inhibitor
    Fulvoferruginin showed cytotoxicity and antifungal activity, especially to Paecilomyces varioti.
    Fulvoferruginin
  • HY-N14192
    Maltophilin
    		Inhibitor
    Maltophilin is a broad-spectrum antifungal antibiotic that has no antibacterial effect against Gram-positive and Gram-negative bacteria.
    Maltophilin
  • HY-168396
    Glioroseinol
    Glioroseinol is a fungal metabolite that can be found in Gliocladium, and is a derivative of Gliorosein (HY-N10228).
    Glioroseinol
  • HY-N15091
    Formamicin
    		Inhibitor
    Formamicin has broad spectrum and strong anti-plant pathogenic fungi activity.
    Formamicin
  • HY-123096
    Silthiofam
    Silthiofam (Silthiopham) is a wheat fungicide used to control take-all disease caused by the soil-borne fungus Gaeumannomyces graminis.
    Silthiofam
  • HY-N14441
    Haliangicin A
    		Inhibitor
    Haliangicin A has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
    Haliangicin A
  • HY-B0852S2
    Tebuconazole-d6
    Tebuconazole-d6 is a deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells.
    Tebuconazole-d<sub>6</sub>
  • HY-N14215
    Polyoxin K
    		Inhibitor
    Polyoxin K is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin K
  • HY-N6805A
    (E)-Isoeugenol acetate
    		Inhibitor
    (E)-Isoeugenol acetate, a Eugenol derivative, possesses antifungal activity.
    (E)-Isoeugenol acetate
  • HY-N14911
    Actinoplanone A
    		Inhibitor
    Actinoplanone A is a polycyclic xanthone antibiotic. Actinoplanone A has strong antimicrobial activities against bacteria and the rice blast fungus. Actinoplanone A is cytotoxic to various tumor cells and has an inhibitory effect on DNA synthesis.
    Actinoplanone A
  • HY-N15110
    Phosmidosine
    		Inhibitor
    Phosmidosine can inhibit the cell cycle progression and cell morphology recovery of srcts-NRK cells. Phosmidosine A has antifungal effects.
    Phosmidosine
  • HY-N0711R
    Carvacrol (Standard)
    		Inhibitor
    Carvacrol (Standard) is the analytical standard of Carvacrol. This product is intended for research and analytical applications. Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations.
    Carvacrol (Standard)
  • HY-169856
    Pradimicin L
    		Inhibitor
    Pradimicin L is a homologue of pradimicin A (HY-132191) that can be isolated from the new type of Streptomyces madurensis, and it has antifungal activity.
    Pradimicin L
  • HY-117089R
    Tetraconazole (Standard)
    		Inhibitor
    Tetraconazole (Standard) is the analytical standard of Tetraconazole. This product is intended for research and analytical applications. Tetraconazole, a chiral triazole fungicide, is widely used for the prevention of plant disease in wheat fields. Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds.
    Tetraconazole (Standard)
  • HY-N13962
    Bagremycin A
    		Inhibitor
    Bagremycin A is found in the strain of Streptomyce sp. Tu 4128. Bagremycin A has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candida albicans.
    Bagremycin A
  • HY-14272R
    Ravuconazole (Standard)
    		Inhibitor
    Ravuconazole (Standard) is the analytical standard of Ravuconazole. This product is intended for research and analytical applications. Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi.
    Ravuconazole (Standard)
  • HY-N14443
    Haliangicin C
    		Inhibitor
    Haliangicin C has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
    Haliangicin C
  • HY-N14585
    Ramulosin
    		Inhibitor
    Ramulosin has an antifungal effect and inhibits the germination of fungal meristems.
    Ramulosin
  • HY-123096R
    Silthiofam (Standard)
    Silthiofam (Standard) is the analytical standard of Silthiofam. This product is intended for research and analytical applications. Silthiofam (Silthiopham) is a wheat fungicide used to control take-all disease caused by the soil-borne fungus Gaeumannomyces graminis.
    Silthiofam (Standard)
  • HY-173452
    DT-23
    		Inhibitor
    DT-23 is a potent antifungal agent with an MIC50 of 15 μg/mL. DT-23 inhibits recombinant Arg1 and Kcs1 with IC50s of 0.6 and 0.68 μM, respectively.
    DT-23
Cat. No. Product Name / Synonyms Application Reactivity