2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1051R
    Flumethasone (Standard)
    Flumethasone (Standard) is the analytical standard of Flumethasone. This product is intended for research and analytical applications. Flumethasone is a corticosteroid, a topical agent used in combination with Clioquinol for the study of otitis externa and otomycosis. When used in animal models, Flumethasone's anti-inflammatory activity is 420 times higher than that of Cortisone.
    Flumethasone (Standard)
  • HY-N14156
    Epelmycin B
    		Inhibitor
    Epelmycin B has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.
    Epelmycin B
  • HY-N14158
    Epelmycin D
    		Inhibitor
    Epelmycin D has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.
    Epelmycin D
  • HY-N14937
    Albaflavenone
    		Inhibitor
    Albaflavenone is a sesquiterpene antibiotic with a zizaene skeleton. Albaflavenone is active against Bacillus subtilis.
    Albaflavenone
  • HY-W716339
    (+)-β-Pinene
    		Inhibitor
    (+)-β-Pinene is an enantiomer of a (-)-β-pinene. (+)-β-pinene has antifungal activity and most likely acts through interference with the cell wall;
    (+)-β-Pinene
  • HY-B2058R
    Triticonazole (Standard)
    		Inhibitor
    Triticonazole (Standard) is the analytical standard of Triticonazole. This product is intended for research and analytical applications. Triticonazole is a triazole pesticide. Triticonazole is an azole fungicide and shows endocrine disrupting activities.
    Triticonazole (Standard)
  • HY-N14659
    Pilatin
    		Inhibitor
    Pilatin has inhibitory effects on bacteria and fungi, and has strong inhibitory effects on the incorporation of thymidin and ureidin into DNA and RNA in Ehrlich carcinoma ascites cells.
    Pilatin
  • HY-Y0051R
    5-Hydroxymethylfurfural (Standard)
    		Inhibitor
    5-Hydroxymethylfurfural (Standard) is the analytical standard of 5-Hydroxymethylfurfural. This product is intended for research and analytical applications. 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
    5-Hydroxymethylfurfural (Standard)
  • HY-W020182R
    α-Terpinene (Standard)
    		Inhibitor
    α-Terpinene (Standard) is the analytical standard of α-Terpinene. This product is intended for research and analytical applications. α-Terpinene (Terpilene) is a monoterpene found in the essential oils of a large variety of foods and aromatic plants such as Mentha piperita. α-Terpinene is active against Trypanosoma evansi and has the potential for trypanosomosis treatment. α-Terpinene has antioxidant and antifungal properties.
    α-Terpinene (Standard)
  • HY-B1852R
    Sulfometuron-methyl (Standard)
    		Inhibitor
    Sulfometuron-methyl (Standard) is the analytical standard of Sulfometuron-methyl. This product is intended for research and analytical applications. Sulfometuron-methyl is a herbicide and also a powerful inhibitor of the enzyme acetolactate synthase (ALS). It exhibits antibacterial and antifungal activities, capable of inhibiting the activity of Salmonella. typhimurium ALS II and Escherichia. coli ALS III.
    Sulfometuron-methyl (Standard)
  • HY-B0133R
    Natamycin (Standard)
    		Inhibitor
    Natamycin (Standard) is the analytical standard of Natamycin. This product is intended for research and analytical applications. Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research.
    Natamycin (Standard)
  • HY-N15528
    Pipercroside A
    		Inhibitor
    Pipercroside A is found in Piper crocatum Ruiz & Pav. Pipercroside A is a CYP51 inhibitor. Pipercroside A has antifungal activity.
    Pipercroside A
  • HY-W741556
    Dehydrogriseofulvin
    		Inhibitor
    Dehydrogriseofulvin can be isolated from Penicillium sp. Dehydrogriseofulvin inhibits Colletotrichum musae with MIC > 1 µg/scrip.
    Dehydrogriseofulvin
  • HY-B1151R
    Climbazole (Standard)
    		Inhibitor
    Climbazole (Standard) is the analytical standard of Climbazole. This product is intended for research and analytical applications. Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450.
    Climbazole (Standard)
  • HY-B0851R
    Triadimenol (Standard)
    		Inhibitor
    Triadimenol (Standard) is the analytical standard of Triadimenol. This product is intended for research and analytical applications. Triadimenol is a triazole fungicide and has been widely used in agriculture. Triadimenol has certain toxicity to animals.
    Triadimenol (Standard)
  • HY-N14135
    Cystothiazole A
    		Inhibitor
    Cystothiazole A has antifungal activity. Cystothiazole A can inhibit candida albicans, saccharomyces cerevisiae and aspergillus smoke with MIC values of 0.4 μg/mL, 0.1 μg/mL and 1.6 μg/mL, respectively. Cystothiazole A also inhibits human tumor cell, such as HPT-116 and K562 cells with MIC values of 130 ng/mL and 110 ng/mL, respectively. Cystothiazole A has no anti-bacterial effect.
    Cystothiazole A
  • HY-W654282
    Myclobutanil-d9
    		Inhibitor
    Myclobutanil-d9 is deuterium labeled Myclobutanil. Myclobutanil is a conazole class fungicide widely used as an agrichemical.
    Myclobutanil-d<sub>9</sub>
  • HY-N14225
    Fumifungin
    		Inhibitor
    Fumifungin has the antifungal activities of Cercospora, Cladosporium, Aspergillus niger, Penicillium digitatum, Trichophyton mentagrophytes, Alternaria, Candida albicans and yeast.
    Fumifungin
  • HY-B0105R
    Ketoconazole (Standard)
    		Inhibitor
    Ketoconazole (Standard) is the analytical standard of Ketoconazole. This product is intended for research and analytical applications. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
    Ketoconazole (Standard)
  • HY-135445
    Prolylrapamycin
    		Inhibitor
    Prolylrapamycin (21-Norrapamycin) is the derivative of Rapamycin (HY-10219). Prolylrapamycin exhibits antifungal activity, that inhibits Candida albicans, Saccharomyces cerevisiae, and Fusarium oxysporum with MIC of 0.125-2 μg/mL.
    Prolylrapamycin
Cat. No. Product Name / Synonyms Application Reactivity