2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N15309
    Torvoside C
    		Inhibitor
    Torvoside C (Torvoside K) is a compound found in Solanum torvum with antifungal activity. The ZOIs and MIC values of Torvoside C against the tested fungi (Alternaria brassicicola, Alternaria geophila, Aspergillus flavus, etc.) range from 33.4% to 87.4% and 31.25 to 250 μg/mL, respectively. Additionally, it exhibits a dose-dependent inhibitory effect on the production of mycotoxins aflatoxin B1 and fumonisin B1, which are produced by A. flavus and F. verticillioides, respectively. Torvoside C can be used for research in the field of antifungal infection.
    Torvoside C
  • HY-D0027R
    7-Amino-4-methylcoumarin (Standard)
    		Inhibitor
    7-Amino-4-methylcoumarin (Standard) is the analytical standard of 7-Amino-4-methylcoumarin. This product is intended for research and analytical applications. 7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.[4]
    7-Amino-4-methylcoumarin (Standard)
  • HY-160238
    Bacillibactin
    		Inhibitor
    Bacillibactin (Corynebactin) is a cyclic tricatecholate siderophore. Bacillibactin’s primary function is to facilitate bacterial iron acquisition by chelating iron ions (Fe3+) from the environment, thereby aiding bacterial survival under iron-limited conditions. Bacillibactin exhibits direct antimicrobial activity, such as inhibition of the growth of the producing bacteria Pseudomonas aeruginosa and Aeromonas veronae, as well as plant pathogens such as Pseudomonas syringae.Bacillibactin can be used in antibacterial and antifungal research.
    Bacillibactin
  • HY-121349
    Aerothionin
    		Inhibitor
    Aerothionin is an antibiotic with potent antimicrobial efficacy against bacteria and fungi. Aerothionin exhibits antitumor efficacy against adrenal pheochromocytomas and extra-adrenal paragangliomas (PPGLs).
    Aerothionin
  • HY-N15037
    Flavomycoin
    		Inhibitor
    Flavomycoin is an antibiotic with antifungal activity.
    Flavomycoin
  • HY-163781
    Antifungal agent 105
    		Inhibitor
    Antifungal agent 105 (compound A25) is a potent antifungal agent. Antifungal agent 105 shows protective and curative effects .
    Antifungal agent 105
  • HY-126637
    Marasmic acid
    		Inhibitor
    Marasmic acid is a sesquiterpenoid with unsaturated dialdehyde functionality, first isolated from the Basidiomycete Marasmus conigenus. Marasmic acid has antibacterial, antifungal, cytotoxic and mutagenic activities, and its broad-spectrum activity is related to the α,β-unsaturated aldehyde group. However, its detailed biological mechanism of action has not been clarified. Previous studies have suggested that marasmic acid may exert its effects by reacting with endogenous nucleophiles or forming pyrrole derivatives. This study found that marasmic acid interferes with the membrane sensor histidine kinase MoSln1p of M. oryzae, superactivates the HOG pathway and causes cell death, indicating that its mechanism of action is different from other unsaturated dialdehyde sesquiterpenoids.
    Marasmic acid
  • HY-176552
    Tubulin polymerization-IN-83
    		Inhibitor
    Tubulin polymerization-IN-83 (Compound A23) is a flavonol derivative. Tubulin polymerization-IN-83 exhibits antifungal activity against various phytopathogenic fungi, with an EC50 of 0.338 μg/mL against Botrytis cinerea. Tubulin polymerization-IN-83 exerts its effects by targeting β-tubulin, disrupting mycelial morphology, and increasing cell membrane permeability, with relatively low ecological and environmental risks.
    Tubulin polymerization-IN-83
  • HY-N15083
    Iodinin
    		Inhibitor
    Iodinin is an antibiotic with antibacterial and fungal properties.
    Iodinin
  • HY-129339
    Akrobomycin
    		Inhibitor
    Akrobomycin is an anthracycline antibiotic. Akrobomycin shows antimicrobial and antitumor activities.
    Akrobomycin
  • HY-174831
    SDH-IN-28
    		Inhibitor
    SDH-IN-28 is a succinate dehydrogenase inhibitor with an IC50 value of 2.65 mg/L. SDH-IN-28 demonstrates broad-spectrum fungicidal efficacy, with EC50 values of 0.21 (Valsa mali), 0.95 (Botrytis cinerea), 0.64 (Rhizoctonia solani), 1.33 (Fusarium graminearum), and 0.66 mg/L (Gaeumannomyces graminis). SDH-IN-28 effectively prevents V. mali infection in apples.
    SDH-IN-28
  • HY-174456
    Succinate dehydrogenase-IN-10
    		Inhibitor
    Succinate dehydrogenase-IN-10 (Compound B5) is a RsSDH (Succinate dehydrogenase of R. solani) inhibitor with an IC50 of 0.12 μM. Succinate dehydrogenase-IN-10 exhibits antifungal activity against R. solani (EC50 of 0.002 μg/mL) and P. pachyrhizi.
    Succinate dehydrogenase-IN-10
  • HY-W014316R
    5-Bromo-5-nitro-1,3-dioxane (Standard)
    		Inhibitor
    5-Bromo-5-nitro-1,3-dioxane (Standard) is the analytical standard of 5-Bromo-5-nitro-1,3-dioxane. This product is intended for research and analytical applications. 5-Bromo-5-nitro-1,3-dioxane, an antimicrobial compound, is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast. 5-Bromo-5-nitro-1,3-dioxane inhibits enzyme activity and subsequent inhibition of microbial growth by the oxidation of essential protein thiol.
    5-Bromo-5-nitro-1,3-dioxane (Standard)
  • HY-N14731
    7-Demethylpiericidin A1
    		Inhibitor
    7-Demethylpiericidin A1 is a pierceridin antibiotic. 7-Demethylpiericidin A1 has antifungal and Gram-negative bacteria activity.
    7-Demethylpiericidin A1
  • HY-B1858S
    Isoprothiolane-d4
    		Inhibitor
    Isoprothiolane-d4 is the deuterium labeled Isoprothiolane (HY-B1858). Isoprothiolane is a blast fungicide with antifungal, anti-inflammatory and insecticidal activities. Isoprothiolane primarily acts on fungi during the penetration and growth stages of infecting hyphae. Isoprothiolane can be used as an insecticide, pesticide, etc. In addition, Isoprothiolane can reduce serum phospholipid and total lipid concentrations, regulating lipid metabolism. Isoprothiolane is also used in the research of fatty liver.
    Isoprothiolane-d<sub>4</sub>
  • HY-N13905
    Alliacol A
    		Inhibitor
    Alliacol A is an antibiotic shows weak antibacterial and antifungal activity. Alliacol A inhibits DNA synthesis in cells of the ascitic form of Ehrlich carcinoma.
    Alliacol A
  • HY-N14121
    Cladosporide A
    		Inhibitor
    Cladosporide A is found in the strain of Cladosporium sp. IFM 49189. Cladosporide A inhibits Aspergillus fumigatus with IC50 of 0.5-4.0 μg/mL, but it has no effect on other filamentous fungi.
    Cladosporide A
  • HY-173021
    Succinate dehydrogenase-IN-7
    		Inhibitor
    Succinate dehydrogenase-IN-7 (Compound 2f) is a Succinate dehydrogenase inhibitor (IC50 = 2.51 μM). Succinate dehydrogenase-IN-7 has fungicidal activity.
    Succinate dehydrogenase-IN-7
  • HY-165611
    (+)-Lupinine
    		Inhibitor
    (+)-Lupinine is an alkaloid derived from leguminous plants (such as those of the Lupinus genus) and can be used to synthesize glycyrrhetinamide salts with fungicidal activity.
    (+)-Lupinine
  • HY-N14690
    Piperazinomycin
    		Inhibitor
    Piperazinomycin has anti-fungal, yeast, some mycobacterium effects, but no anti-bacterial effect.
    Piperazinomycin
Cat. No. Product Name / Synonyms Application Reactivity