2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-134635R
    Dehydrozingerone (Standard)
    		Inhibitor
    Dehydrozingerone (Standard) is the analytical standard of Dehydrozingerone. This product is intended for research and analytical applications. Dehydrozingerone (Compound 10), a structural half analogue of Curcumin (HY-N0005), is a phenolic compound with antibacterial, anticancer, antioxidant, anti-Alzheimer’s and antifungal activity, which is isolated from ginger (Zingiber officinale) rhizomes. Dehydrozingerone shows moderate inhibitory activities on the secretion of HBsAg in HepG 2 cells with an IC50 value of 0.50 mM.
    Dehydrozingerone (Standard)
  • HY-106546
    Tolciclate
    		Inhibitor
    Tolciclate (KC 9147) is an antifungal agent with in vitro inhibitory activity against dermatophytes, effective at concentrations of 0.01-0.1 μg/mL. Tolciclate is colorless and soluble in well-tolerated excipients, and it is more lipophilic than Tolnaftate (HY-B0370). Tolciclate can be used in research related to antifungal infections.
    Tolciclate
  • HY-N14814
    Neobulgarone F
    		Inhibitor
    Neobulgarone F is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone F can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone F
  • HY-N13024
    Radulone A
    		Inhibitor
    Radulone A is a secondary metabolite, which can be isolated from the wood decomposing fungus Granulobasidium vellereum. Radulone A inhibits spore germination of Phlebiopsis gigantea, Coniophora puteana and Heterobasidion occidentale, with concentrations of 10 µM, 500 µM and 100 µM, respectively.
    Radulone A
  • HY-126610
    Dactylfungin A
    		Inhibitor
    Dactylfungin A, an α-pyrone-containing antifungal agent found in Dactylaria parvispora.
    Dactylfungin A
  • HY-B2004R
    Thifluzamide (Standard)
    		Inhibitor
    Thifluzamide (Standard) is the analytical standard of Thifluzamide. This product is intended for research and analytical applications. Thifluzamide, a broad-spectrum succinate dehydrogenase inhibitor (SDHI) fungicide, has been widely used in the controlling of a variety of fungal diseases in rice fields.
    Thifluzamide (Standard)
  • HY-N5198
    Papulacandin C
    		Inhibitor
    Papulacandin C is an antibiotic. Papulacandin C has strong anti-yeast effect, but has no effect on filamentous fungi, bacteria and protozoa.
    Papulacandin C
  • HY-119976R
    Boscalid (Standard)
    		Inhibitor
    Boscalid (Standard) is the analytical standard of Boscalid. This product is intended for research and analytical applications. Boscalid is an anti-fungal agent. Boscalid is a succinate dehydrogenase (SDH) inhibitor.
    Boscalid (Standard)
  • HY-136754
    CYP51-IN-4
    		Inhibitor
    CYP51-IN-2 (compound 1d), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 15.6 ng/mL for Microsporum gypseum and Candida albicans.
    CYP51-IN-4
  • HY-N14409
    Mycoversilin
    		Inhibitor
    Mycoversilin is an antibiotic. Mycoversilin has the activity of inhibiting skin fungi and phytopathogenic fungi, but has no anti-yeast and bacterial activity. Mycoversilin has a strong inhibitory effect on protein synthesis.
    Mycoversilin
  • HY-B2008R
    Famoxadone (Standard)
    		Inhibitor
    Famoxadone (Standard) is the analytical standard of Famoxadone. This product is intended for research and analytical applications. Famoxadone (DPX-JE874) is a fungicide acting against a broad spectrum of fungi and is widely used in Integrated Pest Management strategies in different agricultural crops.
    Famoxadone (Standard)
  • HY-N15057
    Chivosazol A
    		Inhibitor
    Chivosazol A has anti-yeast and filamentous fungal activity and has strong toxicity to mammalian cells.
    Chivosazol A
  • HY-N14878
    Enactin Ⅰb
    		Inhibitor
    Enactin Ib is found in the strain of Streptomyces roseoviridis. Enactin Ib has only weak antifungal activity.
    Enactin Ⅰb
  • HY-N14018
    Glidobactin A
    		Inhibitor
    Glidobactin A is an acyl peptide antibiotic. Glidobactin A has activity against Candida, Aspergillus fumigatus and Trichophyton, but it is not effective against Candida albicans M-9 infection in mice.
    Glidobactin A
  • HY-17395AS1
    Terbinafine-d3
    		Inhibitor
    Terbinafine-d3 (TDT 067-d3) is deuterium labeled Terbinafine. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Terbinafine-d<sub>3</sub>
  • HY-N15375
    Trichomycin B
    		Inhibitor
    Trichomycin B is a polyene macrolide antibiotic that can be isolated from the fermentation products of Streptomyces hachijoensis. Trichomycin B exhibits antibacterial activity against fungi, yeasts, and trichomonas. Trichomycin B can be used in research on antifungal and anti-trichomoniasis infection.
    Trichomycin B
  • HY-N14268
    Ezomycin A1
    		Inhibitor
    Ezomycin A1 is an antifungal antibiotic. Ezomycin A1 is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on Sclerotinia, Botrytis and Candidiasis of crops.
    Ezomycin A1
  • HY-119726A
    Fosmanogepix (tautomerism)
    		Inhibitor
    Fosmanogepix tautomerism (APX001 tautomerism) is a broad-spectrum and orally active anti-invasive fungal compound. Fosmanogepix tautomerism targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi, and inhibition prevents proper localization of cell wall mannoproteins, thereby impairing cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix tautomerism can be used to study invasive fungal infections.
    Fosmanogepix (tautomerism)
  • HY-N11407
    Bagougeramine B
    		Inhibitor
    Bagougeramine B is an orally active nucleoside antibiotic with antimicrobial activity, which is found in Bacillus circulans. Bagougeramine B inhibits the growth of Gram-positive and Gram-negative bacteria and some fungi.
    Bagougeramine B
  • HY-W099582
    Myristamidopropyl dimethylamine
    		Inhibitor
    Myristamidopropyl dimethylamine (MAPD) is an antimicrobial agent (including against bacteria and fungi) and an insecticide, exhibiting inhibitory activity against Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Fusarium solani, and Acanthamoeba polyphaga. Myristamidopropyl dimethylamine can be used in research on microbial-induced keratitis .
    Myristamidopropyl dimethylamine
Cat. No. Product Name / Synonyms Application Reactivity