2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P10304C
    Cyclo(L-Pro-D-Arg)
    		Inhibitor
    Cyclo(Arg-dPro) is an inhibitor of chitinase. Cyclo(Arg-Pro) inhibits the cell separation of Saccharomyces cerevisiae but does not affect its growth. Cyclo(Arg-Pro) inhibits the transition of Candida albicans from yeast to filamentous morphology.
    Cyclo(L-Pro-D-Arg)
  • HY-108422
    Benodanil
    		Inhibitor
    Benodanil (NSC 100499) is a group of benzanilide fungicide, is used extensively in agriculture.
    Benodanil
  • HY-N12893
    Sclerodione
    		Inhibitor
    Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a lipase inhibitor (IC50: 1 μM).
    Sclerodione
  • HY-N14857
    Kanchanamycin C
    		Inhibitor
    Kanchanamycin C has anti-Gram positive and negative bacteria, yeast and filamentous fungus action.
    Kanchanamycin C
  • HY-B0537R
    Pentamidine (Standard)
    		Inhibitor
    Pentamidine (Standard) is the analytical standard of Pentamidine. This product is intended for research and analytical applications. Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
    Pentamidine (Standard)
  • HY-N14124
    Cladosporide D
    		Inhibitor
    Cladosporide D is found in the strain of Cladosporium sp. IFM 49191. Cladosporide D has no antifungal activity.
    Cladosporide D
  • HY-N14376
    Papulacandins D
    		Inhibitor
    Papulacandin D is an antibiotic. Papulacandin D has strong anti-yeast effect, but has no effect on filamentous fungi, bacteria and protozoa.
    Papulacandins D
  • HY-118578R
    Furalaxyl (Standard)
    		Inhibitor
    Furalaxyl (Standard) is the analytical standard of Furalaxyl. This product is intended for research and analytical applications. Furalaxyl (CGA 38140) is a potent fungicide. Furalaxyl is highly selective to fungi of the order of the Peronosporales.
    Furalaxyl (Standard)
  • HY-138223
    6-Prenylindole
    		Inhibitor
    6-Prenylindole is an antifungal agent that can be isolated from Streptomyces.
    6-Prenylindole
  • HY-N14250
    Melithiazole C
    		Inhibitor
    Melithiazol C is an antibiotic. Melithiazole C is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity. Antifungal agent.
    Melithiazole C
  • HY-149450
    Aflastatin A
    Aflastatin A, a microbial metabolite, is an aflatoxin production inhibitor. Aflastatin A inhibits production of both aflatoxin B and G groups.
    Aflastatin A
  • HY-163633
    CYP51-IN-18
    		Inhibitor
    CYP51-IN-18 (compound 2l) is a potent CYP51 inhibitor with an IC50 of 0.219 μg/mL. CYP51-IN-18 shows significant fungicidal activity against B. cinerea with an EC50 of 0.369 μg/mL.
    CYP51-IN-18
  • HY-118699
    Indole-3-thio carboxamide
    		Inhibitor
    Indole-3-thio carboxamide is an antifungal agent. Indole-3-thio carboxamide is a biotransformation product of Camalexin (HY-119502) by plant pathogenic fungi Botrytis cinerea.
    Indole-3-thio carboxamide
  • HY-121214R
    Amisulbrom (Standard)
    		Inhibitor
    Amisulbrom (Standard) is the analytical standard of Amisulbrom (HY-121214). This product is intended for research and analytical applications. Amisulbrom is a sulfonamide fungicide used to control oomycete diseases. Amisulbrom inhibits the cytochrome-bc1 complex of the mitochondrial electron transport system.
    Amisulbrom (Standard)
  • HY-W572386
    2-n-Heptyl-4-quinolinol
    		Inhibitor
    2-n-Heptyl-4-quinolinol has activity against Candida albicans, Staphylococcus aureus, Vibrio anguillarum and V. Harveyi.
    2-n-Heptyl-4-quinolinol
  • HY-111264
    Naphthomycin B
    		Inhibitor
    Naphthomycin B is an antibiotic, which is initially isolated from Streptomyces sp. Naphthomycin B exhibits antimicrobial activities against gram positive bacteria and many fungis.
    Naphthomycin B
  • HY-B1978R
    Iprodione (Standard)
    		Inhibitor
    Iprodione (Standard) is the analytical standard of Iprodione. This product is intended for research and analytical applications. Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats.
    Iprodione (Standard)
  • HY-W782079
    Geraniol-d6 (Major)
    		Inhibitor
    Geraniol-d6 (Major) is the deuterated labeled Geraniol (Major). Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes.
    Geraniol-d<sub>6</sub> (Major)
  • HY-134635R
    Dehydrozingerone (Standard)
    		Inhibitor
    Dehydrozingerone (Standard) is the analytical standard of Dehydrozingerone. This product is intended for research and analytical applications. Dehydrozingerone (Compound 10), a structural half analogue of Curcumin (HY-N0005), is a phenolic compound with antibacterial, anticancer, antioxidant, anti-Alzheimer’s and antifungal activity, which is isolated from ginger (Zingiber officinale) rhizomes. Dehydrozingerone shows moderate inhibitory activities on the secretion of HBsAg in HepG 2 cells with an IC50 value of 0.50 mM.
    Dehydrozingerone (Standard)
  • HY-106546
    Tolciclate
    		Inhibitor
    Tolciclate (KC 9147) is an antifungal agent with in vitro inhibitory activity against dermatophytes, effective at concentrations of 0.01-0.1 μg/mL. Tolciclate is colorless and soluble in well-tolerated excipients, and it is more lipophilic than Tolnaftate (HY-B0370). Tolciclate can be used in research related to antifungal infections.
    Tolciclate
Cat. No. Product Name / Synonyms Application Reactivity