2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14251
    Melithiazole K
    		Inhibitor
    Melithiazol K is an antibiotic. Melithiazole K is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity.
    Melithiazole K
  • HY-N15063
    10-Hydroxyundeca-2,4,6,8-tetraynamide
    		Inhibitor
    10-Hydroxyundeca-2,4,6, 8-tetraynamide is a polyacetylene antibiotic. 10-Hydroxyundeca-2,4,6,8-tetraynamide has anti-Gram-positive bacteria, negative bacteria, yeast, fungus activity and cytotoxicity.
    10-Hydroxyundeca-2,4,6,8-tetraynamide
  • HY-168756
    Byssochlamic acid
    Byssochlamic acid is a secondary metabolite produced by fungal metabolism.
    Byssochlamic acid
  • HY-N15529
    Pipercroside B
    		Inhibitor
    Pipercroside B is found in Piper crocatum Ruiz & Pav. Pipercroside B is a CYP51 inhibitor. Pipercroside B has antifungal activity.
    Pipercroside B
  • HY-B0518AR
    Naftifine hydrochloride (Standard)
    		Inhibitor
    Naftifine (hydrochloride) (Standard) is the analytical standard of Naftifine (hydrochloride). This product is intended for research and analytical applications. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition.
    Naftifine hydrochloride (Standard)
  • HY-130406
    Benthiavalicarb isopropyl
    Benthiavalicarb isopropyl is a fungicide with specific activity against downy mildew and blight. Benthiavalicarb isopropyl is evaluated for use where necessary to control a serious threat to plant health that cannot be treated by other methods, including non-chemical methods. The use of Benthiavalicarb isopropyl can be considered representative of field applications in potatoes. Environmental and human exposures of Benthiavalicarb isopropyl are considered to be negligible.
    Benthiavalicarb isopropyl
  • HY-Y0248R
    (E,E)-Farnesol (Standard)
    (E,​E)​-​Farnesol (Standard) (trans,trans-Farnesol (Standard)) is the analytical standard of (E,​E)​-​Farnesol (HY-Y0248). This product is intended for research and analytical applications. (E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness.
    (E,E)-Farnesol (Standard)
  • HY-A0278R
    Hexaconazole (Standard)
    		Inhibitor
    Hexaconazole (Standard) is the analytical standard of Hexaconazole. This product is intended for research and analytical applications.
    Hexaconazole (Standard)
  • HY-169174
    Antifungal agent 116
    		Inhibitor
    Antifungal agent 116 (compund 1a) has broad-spectrum antifungal activity.
    Antifungal agent 116
  • HY-N14038
    Crocacin A
    		Inhibitor
    Crocacin A has anti-yeast and filamentous fungal activity. Crocacin A can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin A can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum.
    Crocacin A
  • HY-128467R
    Dehydroacetic acid sodium (Standard)
    		Inhibitor
    Dehydroacetic acid (sodium) (Standard) is the analytical standard of Dehydroacetic acid (sodium). This product is intended for research and analytical applications. Dehydroacetic acid sodium, a pyrone derivative acts as an antibacterial and antifungal agent. Dehydroacetic acid possess phytotoxic activity.
    Dehydroacetic acid sodium (Standard)
  • HY-N14923
    Nikkomycin Lz
    		Inhibitor
    Nikkomycin Lz is a nucleoside peptide antifungal compound isolated from genetically engineered Streptomyces tendae TU901. Nikkomycin Lz has antifungal activity against Candida albicans.
    Nikkomycin Lz
  • HY-W741041
    Fluoxastrobin-d4
    		Inhibitor
    Fluoxastrobin-d4 is the deuterium labeled Fluoxastrobin. Fluoxastrobin is a fungicide agent.
    Fluoxastrobin-d<sub>4</sub>
  • HY-N7063S1
    Nerol-d6
    		Inhibitor
    Nerol-d6 is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity.
    Nerol-d<sub>6</sub>
  • HY-N14807
    Neobulgarone A
    		Inhibitor
    Neobulgarone A is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone A can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone A
  • HY-155999
    MoTPS1-IN-1
    		Inhibitor 99.50%
    MoTPS1-IN-1 (Compound j11), an antifungal agent, is a MoTPS1 inhibitor. MoTPS1-IN-1 acts by interation with Glu396 in MoTPS1. MoTPS1-IN-1 inhibits pathogenicity of M. oryzae.
    MoTPS1-IN-1
  • HY-N13929
    Scytalidin
    		Inhibitor
    Scytalidin is a terpenoid antibiotic with antifungal effect.
    Scytalidin
  • HY-N14437
    Pradimicin T2
    		Inhibitor
    Pradimicin T2 is an antibiotic. Pradimicin T2 has activity against filamentous fungi and yeast-like fungi.
    Pradimicin T2
  • HY-121473
    Aklavin
    		Inhibitor
    Aklavin is an antibiotic that shows activity against various bacteriophages, Gram-positive bacteria, and some fungi and viruses.
    Aklavin
  • HY-N15581
    Rishitinol
    		Inhibitor
    Rishitinol is a sesquiterpene alcohol phytoalexin with antifungal activities found in potato tubers infected by Phytophthora infestans. Rishitinol inhibits mycelial growth and spore germination of fungi. Rishitinol is promising for research of plant fungal diseases (such as late blight) .
    Rishitinol
Cat. No. Product Name / Synonyms Application Reactivity