2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-165611
    (+)-Lupinine
    		Inhibitor
    (+)-Lupinine is an alkaloid derived from leguminous plants (such as those of the Lupinus genus) and can be used to synthesize glycyrrhetinamide salts with fungicidal activity.
    (+)-Lupinine
  • HY-N14690
    Piperazinomycin
    		Inhibitor
    Piperazinomycin has anti-fungal, yeast, some mycobacterium effects, but no anti-bacterial effect.
    Piperazinomycin
  • HY-N3088
    Phaseollidin hydrate
    		Inhibitor
    Phaseollidin hydrate is the hydrate form of the antimicrobial phytoalexin Phaseollidin, which has lower antifungal activity than the original Phaseollidin.
    Phaseollidin hydrate
  • HY-A0133R
    Chlorphenesin (Standard)
    		Inhibitor
    Chlorphenesin (Standard) is the analytical standard of Chlorphenesin. This product is intended for research and analytical applications. Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics.
    Chlorphenesin (Standard)
  • HY-170974
    SDH-IN-20
    		Inhibitor
    SDH-IN-20 (compound A19) is an antifungal agent. SDH-IN-20 against Verticillium dahlia, R. solani with EC50s of less than 3.0 μg/mL, 2.87 μg/mL. SDH-IN-20 exerts its highly antifungal effects by acting as an effective succinate dehydrogenase (SDH) inhibitor with an IC50 of 29.33 μM. SDH-IN-20 adversely impacts the integrity of cell membranes and mycelial morphologies of R. solani.
    SDH-IN-20
  • HY-123002R
    Pyrifenox (Standard)
    		Inhibitor
    Pyrifenox (Standard) is the analytical standard of Pyrifenox. This product is intended for research and analytical applications. Pyrifenox is a fungicide, which is used in fruits, ornamentals, and vegetables. Pyrifenox can be utilized as one of the assessment criteria for environmental and food safety.
    Pyrifenox (Standard)
  • HY-B0348R
    Liranaftate (Standard)
    		Inhibitor
    Liranaftate (Standard) is the analytical standard of Liranaftate. This product is intended for research and analytical applications. Liranaftate (Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. Liranaftate can be used for the research of dermatophytes. Liranaftate also suppresses fungal element-promoted production of IL-8 and experimental inflammation.
    Liranaftate (Standard)
  • HY-W019803R
    Diclobutrazol (Standard)
    		Inhibitor
    Diclobutrazol (Standard) is the analytical standard of Diclobutrazol. This product is intended for research and analytical applications. Diclobutrazol, a systemic fungicide, is highly active against rusts, powdery mildews, and other fungal phytopathogens. Diclobutrazol can be used as a pesticide to control of various crop diseases.
    Diclobutrazol (Standard)
  • HY-N14509
    Queenslandon
    		Inhibitor
    Queenslandon has moderate anti-streptomyces, penicillium, Penicillium, Aspergillus fumigatus, aspergillus flavus and other fungal activities. And it has no effect on bacteria.
    Queenslandon
  • HY-116541R
    Acibenzolar-S-methyl (Standard)
    		Inhibitor
    Acibenzolar-S-methyl (Standard) is the analytical standard of Acibenzolar-S-methyl. This product is intended for research and analytical applications. Acibenzolar-S-methyl (ASM) is a plant resistance inducer that mimics pathogen-host interactions and leads to systemic acquired resistance in plants. Acibenzolar-S-methyl helps reduce the use of pesticides and can be used in research to prevent plant diseases.
    Acibenzolar-S-methyl (Standard)
  • HY-B1863R
    Iprobenfos (Standard)
    		Inhibitor
    Iprobenfos (Standard) is the analytical standard of Iprobenfos (HY-B1863). This product is intended for research and analytical applications. Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity.
    Iprobenfos (Standard)
  • HY-B0359R
    Fenticonazole Nitrate (Standard)
    		Inhibitor
    Fenticonazole (Nitrate) (Standard) is the analytical standard of Fenticonazole (Nitrate). This product is intended for research and analytical applications. Fenticonazole Nitrate is an antifungal imidazole ring derivative. Fenticonazole Nitrate operates via hindering ergosterol integration, and sequentially destructing the cytoplasmatic outer membrane. Fenticonazole Nitrate is effective against Gram-positive bacteria, mycoses, and vaginal candidiasis.
    Fenticonazole Nitrate (Standard)
  • HY-N14984
    Galbonolides A
    		Inhibitor
    Galbonolides A exhibits biological activity against a broad spectrum of fungi.
    Galbonolides A
  • HY-128429S
    trans-2-Hexenal-d2-1
    		Inhibitor
    trans-2-Hexenal-d2-1 is the deuterium labeled trans-2-Hexenal (HY-128429). trans-2-Hexenal ((E)-2-Hexenal) is a volatile compound widely present in fresh plants, vegetables, and fruits, with a unique leafy aroma. trans-2-Hexenal has antifungal activity and can also inhibit the germination of soybean seeds and the growth of seedlings. In addition, trans-2-Hexenal can be used to determine low-molecular-weight carbonyl compounds that are reactive with biological nucleophiles in biological samples.
    trans-2-Hexenal-d<sub>2</sub>-1
  • HY-N14112
    Cuevaene B
    		Inhibitor
    Cuevaene B can be isolated from the strain of gdmAI-disrupted Streptomyces sp. LZ35 and. Cuevaene B displays moderate activity against Gram-positive bacteria (e.g., Bacillus subtilis strain ATCC 11060) and modest activity against fungi (e.g., Fusarium verticillioides strain S68 and Rhizoctonia solani strain GXE4).
    Cuevaene B
  • HY-126114R
    Lupeol acetate (Standard)
    		Inhibitor
    Lupeol acetate (Standard) is the analytical standard of Lupeol acetate. This product is intended for research and analytical applications. Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility.
    Lupeol acetate (Standard)
  • HY-N8431
    5-Geranoxy-7-methoxycoumarin
    		Inhibitor
    5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and ?antibacterial?activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis.
    5-Geranoxy-7-methoxycoumarin
  • HY-N14853
    Ossamycin
    		Inhibitor
    Ossamycin is a macrolide antibiotic. Ossamycin has anti-fungal effect, and it has weaker anti-Gram-positive bacterial effect. Ossamycin inhibits L cells, Epstein-Barr ascites cancer cells, KB cells, sarcoma-180 cells, L-1210 cells, HeLa cells in cell culture with IC50s (μg/mL) of 0.007, 0.008, 0.005, 0.008, 0.003, 0.005, respectively.
    Ossamycin
  • HY-N14472
    Fusacandin B
    		Inhibitor
    Fusacandin B inhibits (1,3)-β-glucan synthetase and has antifungal properties.
    Fusacandin B
  • HY-77995R
    2-Methoxybenzaldehyde (Standard)
    		Inhibitor
    2-Methoxybenzaldehyde (Standard) is the analytical standard of 2-Methoxybenzaldehyde. This product is intended for research and analytical applications. 2-Methoxybenzaldehyde (o-Anisaldehyde) is a bacterial/fungal inhibitor with a BA50 value of 0.19 for Salmonella. 2-Methoxybenzaldehyde can be used for the study of bacterial and fungal infectious diseases.
    2-Methoxybenzaldehyde (Standard)
Cat. No. Product Name / Synonyms Application Reactivity