2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-Y1825R
    Benzimidazole (Standard)
    		Inhibitor
    Benzimidazole (Standard) is the analytical standard of Benzimidazole. This product is intended for research and analytical applications. Benzimidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Benzimidazole (Standard)
  • HY-123510
    NSC-670224
    		Inhibitor
    NSC-670224 is toxic to Saccharomyces cerevisiae at low micromolar concentration (LC50: 3.2 μM).
    NSC-670224
  • HY-N7123S1
    Sulfacetamide-13C6
    		Inhibitor
    Sulfacetamide-13C6 (Sulphacetamide13C6) is the 13C6 labeled Sulfacetamide (HY-N7123). Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide has antifungal and antibacterial activities.
    Sulfacetamide-<sup>13</sup>C<sub>6</sub>
  • HY-136355S
    Picoxystrobin-d3
    		Inhibitor
    Picoxystrobin-d3 is the deuterium labeled Picoxystrobin (HY-136355). Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity.
    Picoxystrobin-d<sub>3</sub>
  • HY-N6038R
    Gartanin (Standard)
    Gartanin (Standard) is the analytical standard of Gartanin. This product is intended for research and analytical applications. Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells.
    Gartanin (Standard)
  • HY-125969
    Rtt109 inhibitor 1
    		Inhibitor
    Rtt109 inhibitor 1 (Compound 1) is an inhibitor for histone acetyltransferase Rtt109 through a tight binding, uncompetitive system. Rtt109 inhibitor 1 exhibits antifungal activity through acetylation at H3K56 site.
    Rtt109 inhibitor 1
  • HY-B2026
    Propamocarb
    		Inhibitor
    Propamocarb is a systemic fungicide. Propamocarb is widely used to protect cucumbers, tomatoes and other plants from pathogens.
    Propamocarb
  • HY-178088
    L-731120
    		Inhibitor
    L-731120 is an alkyl citrate zargozaga acid A analogue, which is secondary metabolite produced by fungal fermentation. L-731120 shows inhibitory activity against squalene synthase (SQS) (IC50 = 260 nM). L-731120 can inhibit the synthesis of cholesterol in the liver. L-731120 can be used for the research of infection and metabolic disease, such as hypercholesterolemia.
    L-731120
  • HY-N12682
    Phoslactomycin C
    		Inhibitor
    Phoslactomycin C has weak effect against Gram-positive bacteria, but has strong effect against fungi.
    Phoslactomycin C
  • HY-N1289
    Sequosempervirin B
    		Inhibitor
    Sequosempervirin B, a norlignan isolated from the branches and leaves of Sequoia sempervirens, has antifungal properties. Sequosempervirin B has an inhibitory effect on cyclic AMP phosphodiesterase.
    Sequosempervirin B
  • HY-151423
    Antifungal agent 39
    		Inhibitor
    Antifungal agent 39 (Compound 9h) is a broad-spectrum antifungal agent.
    Antifungal agent 39
  • HY-N6635R
    trans-Nerolidol (Standard)
    		Inhibitor
    trans-Nerolidol (Standard) is the analytical standard of trans-Nerolidol. This product is intended for research and analytical applications. trans-Nerolidol improves the anti-proliferative effect of Doxorubicin (DOX) (HY-15142A) against intestinal cancer and breast cancer cells in vitro. trans-Nerolidol increases accumulation of DOX inside cells in vitro. trans-Nerolidol activates apoptosis in vivo.
    trans-Nerolidol (Standard)
  • HY-139161
    Penflufen
    		Inhibitor 99.70%
    Penflufen is a highly efficient, broad-spectrum succinate dehydrogenase inhibitor (SDHI). Penflufen can be used as a fungicide and has broad bioactivity against many fungal diseases, including potato black scurf, wheat sharp eyespot, rice sheath blight, and root rot in peanut and other similar fungal diseases.
    Penflufen
  • HY-N0415R
    Trigonelline chloride (Standard)
    		Inhibitor
    Trigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.
    Trigonelline chloride (Standard)
  • HY-23155S
    2-Phenylethyl isothiocyanate-d5
    2-Phenylethyl isothiocyanate-d5 isothiocyanate-d5 is the deuterium labeled 2-Phenylethyl isothiocyanate[1]. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity[2][3].
    2-Phenylethyl isothiocyanate-d<sub>5</sub>
  • HY-123155
    Pyrimorph
    		Inhibitor
    Pyrimorph is a fungicide with excellent antifungal activity against oomycetes.
    Pyrimorph
  • HY-133169
    Topazolin
    		Inhibitor
    Topazolin is a flavone. Topazolin has weak fungi-toxic activity against Cladosporium herbarum AHU 9262.
    Topazolin
  • HY-N10611
    Elsinochrome A
    		Inhibitor
    Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm).
    Elsinochrome A
  • HY-113219S
    Hydroxyphenyllactic acid-d4
    Hydroxyphenyllactic acid-d4 is the deuterium labeled Hydroxyphenyllactic acid (HY-113219). Hydroxyphenyllactic acid is an antifungal metabolite.
    Hydroxyphenyllactic acid-d<sub>4</sub>
  • HY-N8258
    Aszonapyrone A
    Aszonapyrone A is a metabolite produced by Aspergillus zonatus.
    Aszonapyrone A
Cat. No. Product Name / Synonyms Application Reactivity