2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14437
    Pradimicin T2
    		Inhibitor
    Pradimicin T2 is an antibiotic. Pradimicin T2 has activity against filamentous fungi and yeast-like fungi.
    Pradimicin T2
  • HY-121473
    Aklavin
    		Inhibitor
    Aklavin is an antibiotic that shows activity against various bacteriophages, Gram-positive bacteria, and some fungi and viruses.
    Aklavin
  • HY-N15581
    Rishitinol
    		Inhibitor
    Rishitinol is a sesquiterpene alcohol phytoalexin with antifungal activities found in potato tubers infected by Phytophthora infestans. Rishitinol inhibits mycelial growth and spore germination of fungi. Rishitinol is promising for research of plant fungal diseases (such as late blight) .
    Rishitinol
  • HY-168446
    PKR-IN-1
    		Inhibitor
    PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor that has antifungal activity, with an EC50 of 0.21 μg/mL for R. solani.
    PKR-IN-1
  • HY-173428
    Antifungal agent 130
    		Inhibitor
    Antifungal agent 130 (Compound A7) is an orally active antifungal agent. Antifungal agent 130 has good antifungal activity against Candida albicans (MIC = 0.12 ng/mL) and Cryptococcus neoformans (MIC = 0.12 ng/mL) and has excellent antivirulence effect. Antifungal agent 130 exerts its antifungal effect by disrupting the iron homeostasis of fungal cells and inducing oxidative stress damage. Antifungal agent 130 can inhibit the formation of fungal virulence factors (such as biofilm, capsule, urease and melanin). Antifungal agent 130 has good antifungal effect and can be used in the study of drug-resistant fungal infections.
    Antifungal agent 130
  • HY-N14826
    Nanaomycin E
    		Inhibitor
    Nanaomycin E is an antibiotic. Nanaomycin E has activity against Gram-positive bacteria and fungi.
    Nanaomycin E
  • HY-N13916
    Alternaric acid
    Alternaric acid is a host-specific toxin produced by the plant fungal. In the presence of Ca2+ and Mg2+, Alternaric acid stimulates phosphorylation of His-tagged cytosolic kinase RiCDPK2.
    Alternaric acid
  • HY-N15084
    Isocycloheximide
    		Inhibitor
    Isocycloheximide has antifungal effects.
    Isocycloheximide
  • HY-N14808
    Neobulgarone B
    		Inhibitor
    Neobulgarone B is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone B can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone B
  • HY-129580
    Nannochelin B
    		Inhibitor
    Nannochelin B is a novel citrate-hydroxamate siderophore with a growth-inhibitory activity against some bacteria and fungi.
    Nannochelin B
  • HY-B0364AR
    Dyclonine hydrochloride (Standard)
    		Inhibitor
    Dyclonine (hydrochloride) (Standard) is the analytical standard of Dyclonine (hydrochloride). This product is intended for research and analytical applications. Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain.
    Dyclonine hydrochloride (Standard)
  • HY-W587878
    Thujopsene
    		Inhibitor
    Thujopsene is the inhibitor for cytochrome P450, that inhibits CYP2B6, CYP3A4, CYP2C19, CYP2C8, CYP2C9 with IC50s of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. Thujopsene binds to PKM2, inhibits the metabolism pathway of cancer cell, induces apoptosis in MKN45, thereby exhibiting antitumor efficacy. Thujopsene exhibits anti-termite and antifungal activities through autoxidation.
    Thujopsene
  • HY-N14256
    Amycin B
    		Inhibitor
    Amycin B, a natural Niphimycin analog, is active against Gram-positive bacteria and fungi.
    Amycin B
  • HY-N7236
    Pervicoside B
    		Inhibitor
    Pervicoside B is a glycoside C isolated from Neothyone gibbosa sea cucumber. In vitro studies have shown that Pervicoside B has a potent antiparasitic effect against Leishmania mexicana, inhibiting 100% of promastigotes at 5-10 μg/mL. Pervicoside B also exhibits strong antifungal activity against Aspergillus niger, with MIC values ranging from 4.65 to 16.7 μg/mL. Pervicoside B has potential applications in the inhibition of parasitic infections and fungal diseases.
    Pervicoside B
  • HY-10980R
    Tavaborole (Standard)
    		Inhibitor
    Tavaborole (Standard) is the analytical standard of Tavaborole. This product is intended for research and analytical applications. Tavaborole (AN-2690) is an antifungal agent with activity against Trichophyton species, in a topical solution formulation for the potential treatment of onychomycosis.
    Tavaborole (Standard)
  • HY-N3569
    Cerbinal
    		Inhibitor
    Cerbinal is a natural compound isolated from Gardenia jasminoides Ellis. Cerbinal has antifungal activity.
    Cerbinal
  • HY-126660
    Cinerubin A
    		Inhibitor
    Cinerubin A (Cinerubine A) has anti-Gram-positive bacteria, mycobacterium, fungis and amoeba activity, and has strong effect on mouse adenocarcinoma E0771.
    Cinerubin A
  • HY-107211
    Echinocandin B nucleus
    		Control
    Echinocandin B nucleus (A-30912 A nucleus) is the reaction product catalyzed by Echinocandin B (HY-125723) deacylase. Echinocandin B nucleus serves as an intermediate for the synthesis of semi-synthetic antifungal agents.
    Echinocandin B nucleus
  • HY-N2552R
    Vitamin K5 hydrochloride (Standard)
    		Inhibitor
    Vitamin K5 (hydrochloride) (Standard) is the analytical standard of Vitamin K5 (hydrochloride). This product is intended for research and analytical applications. Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages[1][2][3].
    Vitamin K5 hydrochloride (Standard)
  • HY-W391940
    (Rac)-Amorolfine hydrochloride
    (Rac)-Amorolfine hydrochloride is the racemic form of Amorolfine hydrochloride. Amorolfine (Ro 14-4767/002) hydrochloride (HY-B0238) is an effective antifungal agent. Amorolfine hydrochloride inhibits the biosynthesis of ergosterol and has research potential for treating onychomycosis caused by Neoscytalidium dimidiatum.
    (Rac)-Amorolfine hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity