2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-169202
    Antifungal agent 118
    		Inhibitor
    Antifungal agent 118 (compund C22) inhibits the hyphal growth of V. mali by inducing oxidative damage and disrupting the integrity of the cell membrane.
    Antifungal agent 118
  • HY-N14171
    Epicorazine A
    		Inhibitor
    Epicorazine A has activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE), MICs of 12.5-25 μg/mL. Epicorazine A also has effect on Candida albicans with a MIC of 25 μg/mL.
    Epicorazine A
  • HY-12772S3
    Hydroxy Itraconazole-d6
    		Inhibitor
    Hydroxy Itraconazole-d6 (R-63373-d6) is deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
    Hydroxy Itraconazole-d<sub>6</sub>
  • HY-W751400
    Solasodine hydrochloride
    		Inhibitor
    Solasodine (Purapuridine) hydrochloride is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine hydrochloride induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine hydrochloride has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities.
    Solasodine hydrochloride
  • HY-N14251
    Melithiazole K
    		Inhibitor
    Melithiazol K is an antibiotic. Melithiazole K is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity.
    Melithiazole K
  • HY-N15063
    10-Hydroxyundeca-2,4,6,8-tetraynamide
    		Inhibitor
    10-Hydroxyundeca-2,4,6, 8-tetraynamide is a polyacetylene antibiotic. 10-Hydroxyundeca-2,4,6,8-tetraynamide has anti-Gram-positive bacteria, negative bacteria, yeast, fungus activity and cytotoxicity.
    10-Hydroxyundeca-2,4,6,8-tetraynamide
  • HY-168756
    Byssochlamic acid
    Byssochlamic acid is a secondary metabolite produced by fungal metabolism.
    Byssochlamic acid
  • HY-N15529
    Pipercroside B
    		Inhibitor
    Pipercroside B is found in Piper crocatum Ruiz & Pav. Pipercroside B is a CYP51 inhibitor. Pipercroside B has antifungal activity.
    Pipercroside B
  • HY-B0518AR
    Naftifine hydrochloride (Standard)
    		Inhibitor
    Naftifine (hydrochloride) (Standard) is the analytical standard of Naftifine (hydrochloride). This product is intended for research and analytical applications. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition.
    Naftifine hydrochloride (Standard)
  • HY-130406
    Benthiavalicarb isopropyl
    Benthiavalicarb isopropyl is a fungicide with specific activity against downy mildew and blight. Benthiavalicarb isopropyl is evaluated for use where necessary to control a serious threat to plant health that cannot be treated by other methods, including non-chemical methods. The use of Benthiavalicarb isopropyl can be considered representative of field applications in potatoes. Environmental and human exposures of Benthiavalicarb isopropyl are considered to be negligible.
    Benthiavalicarb isopropyl
  • HY-A0278R
    Hexaconazole (Standard)
    		Inhibitor
    Hexaconazole (Standard) is the analytical standard of Hexaconazole. This product is intended for research and analytical applications.
    Hexaconazole (Standard)
  • HY-169174
    Antifungal agent 116
    		Inhibitor
    Antifungal agent 116 (compund 1a) has broad-spectrum antifungal activity.
    Antifungal agent 116
  • HY-N14038
    Crocacin A
    		Inhibitor
    Crocacin A has anti-yeast and filamentous fungal activity. Crocacin A can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin A can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum.
    Crocacin A
  • HY-128467R
    Dehydroacetic acid sodium (Standard)
    		Inhibitor
    Dehydroacetic acid (sodium) (Standard) is the analytical standard of Dehydroacetic acid (sodium). This product is intended for research and analytical applications. Dehydroacetic acid sodium, a pyrone derivative acts as an antibacterial and antifungal agent. Dehydroacetic acid possess phytotoxic activity.
    Dehydroacetic acid sodium (Standard)
  • HY-N14923
    Nikkomycin Lz
    		Inhibitor
    Nikkomycin Lz is a nucleoside peptide antifungal compound isolated from genetically engineered Streptomyces tendae TU901. Nikkomycin Lz has antifungal activity against Candida albicans.
    Nikkomycin Lz
  • HY-W741041
    Fluoxastrobin-d4
    		Inhibitor
    Fluoxastrobin-d4 is the deuterium labeled Fluoxastrobin. Fluoxastrobin is a fungicide agent.
    Fluoxastrobin-d<sub>4</sub>
  • HY-N7063S1
    Nerol-d6
    		Inhibitor
    Nerol-d6 is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity.
    Nerol-d<sub>6</sub>
  • HY-N14807
    Neobulgarone A
    		Inhibitor
    Neobulgarone A is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone A can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone A
  • HY-155999
    MoTPS1-IN-1
    		Inhibitor 99.50%
    MoTPS1-IN-1 (Compound j11), an antifungal agent, is a MoTPS1 inhibitor. MoTPS1-IN-1 acts by interation with Glu396 in MoTPS1. MoTPS1-IN-1 inhibits pathogenicity of M. oryzae.
    MoTPS1-IN-1
  • HY-N13929
    Scytalidin
    		Inhibitor
    Scytalidin is a terpenoid antibiotic with antifungal effect.
    Scytalidin
Cat. No. Product Name / Synonyms Application Reactivity