Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (2277)
Antibodies (1)
Related Compound Screening Libraries (1)

By Effects:	Controls (3) Inhibitors (2038) Antagonists (3) Modulators (2) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N5162

Arborcandin C	Inhibitor
Arborcandin C is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin C exhibits IC₅₀ values of 0.15 μg/mL and 0.015 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin C has an MIC of 1-2 μg/mL against the genus Candida.

HY-W014589S

2,4-Di-tert-butylphenol-d₁₉
2,4-Di-tert-butylphenol-d₁₉ (2,4-DTBP-d₁₉) is the deuterium labeled 2,4-Di-tert-butylphenol (HY-W014589). 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances.

HY-123077

Norsanguinarine	Inhibitor
Norsanguinarine, an alkaloid, has antifungal activity against Alternaria brassicicola, Curvularia maculans at 1000 ppm.

HY-155670

Antifungal agent 65
Antifungal agent 65 (Compound 5d) is a fungicidal agent with excellent fungicidal activities against Fusarium oxysporum f.sp. cucumerinum. Antifungal agent 65 can be used for antiviral and fungicidal research.

HY-17006R

Caspofungin diacetate (Standard)	Inhibitor
Caspofungin (diacetate) (Standard) is the analytical standard of Caspofungin (diacetate). This product is intended for research and analytical applications. Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.

HY-P10410

AEC5	Inhibitor
AEC5 is a Lipopeptoid with antifungal activity against Cryptococcus neoformans. AEC5 has no observable cytotoxicity against human lung, liver, or red blood cells at the MIC value (6.3 μg/mL) for Cryptococcus neoformans.

HY-116975

Enoxastrobin	Inhibitor
Enoxastrobin (Enestroburin) is an anti-fungal agent. Enoxastrobin is active against P. oryzae and B. cinerea.

HY-168066

Antifungal agent 117	Inhibitor
Antifungal agent 117 is a bis-pyrazole carboxamide derivative with antifungal activity, exhibiting an EC₅₀ value of 11.58 mg/L against Sclerotinia sclerotiorum. Antifungal agent 117 increases cell membrane permeability, causing an imbalance in osmotic pressure inside and outside the cell, and induces the accumulation of reactive oxygen species (ROS), leading to oxidative damage to the cell membrane, resulting in leakage of cellular contents and eventually cell death. RNA sequencing analysis reveals that Antifungal agent 117 downregulates catalase genes and upregulates neutral ceramidase genes, disrupting cell membrane structure, accelerating sphingolipid metabolism, and promoting cell death. Antifungal agent 117 shows great potential in the fields of plant protection and antifungal infection.

HY-177042

Hsp90-IN-41	Inhibitor
Hsp90-IN-41 (Compound C1) is an inhibitor of Hsp90 (IC₅₀ = 0.044 μM). Hsp90-IN-41 exhibits antifungal and antitumor (IC₅₀ = 0.049 μM) activities in vitro.

HY-144694

HDAC/HSP90-IN-3	Inhibitor
HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC₅₀ values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1.

HY-119502R

Camalexin (Standard)	Inhibitor
Camalexin (Standard) is the analytical standard of Camalexin. This product is intended for research and analytical applications. Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production[1][2][3].

HY-172363

Succinate dehydrogenase-IN-6	Inhibitor
Succinate dehydrogenase-IN-6 (Compound E23) is the inhibitor for succinate dehydrogenase that inhibits SDH in Rhizoctonia solani with an IC₅₀ of 11.76 μM. Succinate dehydrogenase-IN-6 disrupts fungal cell membrane, exhibits board-spectrum antifungal activity that inhibits R. solani, V. dahliae, A. solani and C. gloeosporioides with EC₅₀s of 0.41, 0.27, 1.15, 0.27 μg/mL, respectively. Succinate dehydrogenase-IN-6 exhibits no significant toxicity in rice and zebrafish (LC₅₀ > 12.5 μg/mL).

HY-19377

SS-750	Inhibitor
SS-750 is an orally active Triazole derivative and antifungal agent. SS-750 binds to fungal cytochrome P450. SS-750 shows antifungal activities against Candida species and C. neoformans strains tested. SS750 shows MIC₉₀ values of 0.25, 1, and 2 μg/mL against Candida parapsilosis, C. krusei, and C. glabrata, respectively. SS-750 improves systemic and pulmonary candidiasis caused by C. albicans.

HY-162776

Succinate dehydrogenase-IN-3	Inhibitor
Succinate dehydrogenase-IN-3 (Ig) is an inhibitor of Succinate dehydrogenase (SDH). Succinate dehydrogenase-IN-3 has antifungal activity.

HY-N11505

Isopicropodophyllone	Inhibitor
Isopicropodophyllone, a natural compound that can be isolated from leaves of Podophyllum hexandrum, possesses antifungal activity.

HY-B1978S

Iprodione-d₅
Iprodione-d₅ is the deuterium labeled Iprodione. Iprodione, a dicarboximide fungicide, has a highly specific action, with a capacity to cause oxidative damage through production of free oxygen radicals (ROS). Iprodione does not appear to be species selective.

HY-168648

DNA Gyrase/DHFR-IN-1	Inhibitor
DNA Gyrase/DHFR-IN-1 is a dual inhibitor of bacterial DNA gyrase and DHFR, with IC₅₀s of 182 μM and 3.90 μM for E. coli DNA gyrase and DHFR respectively. DNA Gyrase/DHFR-IN-1 has bactericidal and antifungal activity.

HY-N3457

Isosativan	Inhibitor
Isosativan is a natural product that can be found in Trifolium hybridum. Isosativan shows antifungal activity.

HY-136915

Pyrisoxazole	Inhibitor
Pyrisoxazole (SYP-Z048) is a fungicide.

HY-138145

8-Acetyl-7-hydroxycoumarin	Inhibitor
8-Acetyl-7-hydroxycoumarin is a coumarin-like compound found in Mexican patchouli (Tagetes lucida) that has anti-bacterial and anti-fungal activities.

Antifungal Compound Library

Compound library containing all kinds of molecules with anti-fungal activity.

463compounds HY-L048

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Fungal

Fungal

Fungal Related Products (2277)

Antibodies (1)

Related Compound Screening Libraries (1)

Fungal Related Products (2277):