1. Signaling Pathways
  2. Anti-infection
  3. Fungal

Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-141846
    Antifungal agent 17
    Inhibitor
    Antifungal agent 17 exhibits excellent antifungal properties against B. cinerea with an EC50 value of 2.86 μg/mL.
    Antifungal agent 17
  • HY-N9930
    Effusanin B
    Inhibitor
    Effusanin B (Compound 3) is a diterpenoid can be isolated from Rabdosia effusa (Maxim.) Hara. Effusanin B (Compound 3) has antifungal activity.
    Effusanin B
  • HY-155127
    Antiproliferative agent-33
    Inhibitor
    Antiproliferative agent-33 (Compound 2g) is an anti-proliferative, antifungal, and antibacterial agent. Antiproliferative agent-33 inhibits MDA-MB-231 cell proliferation (IC50: 16.38 μM). Antiproliferative agent-33 inhibits gram-negative bacteria growth, and inhibits S. faecalis with an MIC value of 8 μg/mL.
    Antiproliferative agent-33
  • HY-121004
    Bikaverin
    Inhibitor
    Bikaverin (Lycopersin) is a reddish pigment produced by different fungal species. Bikaverin shows antibiotic properties against certain protozoa and fungi.
    Bikaverin
  • HY-122943
    Moracin D
    Inhibitor
    Moracin D is a flavonoid that can be isolated from Morus alba. Moracin D induces cell apoptosis and shows hypoglycemic, antiadipogenic, antifungal and antitumor effects. Moracin D can be used for fungal infection and breast cancer research.
    Moracin D
  • HY-114595
    Hemigossypol
    Inhibitor
    Hemigossypol (Isohemigossypol) is a sesquiterpene natural product that can be isolated from Gossypium barbadense. Hemigossypol has antifungal activity.
    Hemigossypol
  • HY-N6869R
    Dehydroabietic acid (Standard)
    Inhibitor
    Dehydroabietic acid (Standard) is the analytical standard of Dehydroabietic acid. This product is intended for research and analytical applications. Dehydroabietic acid is a diterpene resin acid that can be isolated from Pinus and Picea. Dehydroabietic acid has anti-bacterial, anti-fungal, anti-inflammatory, and anticancer activities. Dehydroabietic acid is a dual PPAR-α/γ agonist and PPAR-γ partial agonist, which can attenuate insulin resistance (IR) and hepatic steatosis induced by HFD-consumption in mice.
    Dehydroabietic acid (Standard)
  • HY-116214S
    Cyprodinil-d5
    Inhibitor
    Cyprodinil-d5(CGA-219417-d5) is the deuterium labeled Cyprodinil (HY-116214). Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens.
    Cyprodinil-d<sub>5</sub>
  • HY-N7222
    Janthitrem F
    Janthitrem F is a metabolite isolated from tremorigen-producing Penicillium and a potential causative agent of ryegrass spurt disease.
    Janthitrem F
  • HY-111067
    (4S)-(+)-Ascochin
    Inhibitor
    (4S)-(+)-Ascochin is an antifungal agent against Microbotryum violaceum, Phytophthora infestans and Septoria tritici. (4S)-(+)-Ascochin also exhibits antialgal activity against Chlorella fusca.
    (4S)-(+)-Ascochin
  • HY-B1263R
    Chlorobutanol (Standard)
    Inhibitor
    Chlorobutanol (Standard) is the analytical standard of Chlorobutanol. This product is intended for research and analytical applications. Chlorobutanol is a pharmaceutical preservative. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry.
    Chlorobutanol (Standard)
  • HY-17011
    Croconazole
    Inhibitor 99.24%
    Croconazole is an antifungal agent containing imidazole rings. Croconazole has a unique structural feature of aryl vinyl at the imidazole ring N-1. Croconazole can be used for the identification and quantitative study of major metabolites in rat urine and bile .
    Croconazole
  • HY-16561G
    Resveratrol (GMP)
    Inhibitor
    Resveratrol (GMP) is Resveratrol (HY-16561) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
    Resveratrol (GMP)
  • HY-N10905
    Rabdoserrin A
    Inhibitor
    Rabdoserrin A is a diterpenoid. Rabdoserrin A has antifungal activity.
    Rabdoserrin A
  • HY-P2318
    Bac2A TFA
    Inhibitor
    Bac2A TFA is an antimicrobial and immunomodulatory peptide. Bac2A TFA is a linear variant of bactenecin and is very effective against fungal pathogens.
    Bac2A TFA
  • HY-P1791
    Lactoferrin (17-41)
    Inhibitor 98.89%
    Lactoferrin 17-41 (Lactoferricin B), a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 has antitumor activities.
    Lactoferrin (17-41)
  • HY-W582504
    Chlorotris(triphenylphosphine)copper
    Inhibitor
    Chlorotris(triphenylphosphine)copper (CuCl(TPP)₃) is a DNA-targeted metal complex. Chlorotris(triphenylphosphine)copper involves non-covalent interactions (such as groove binding mode) through the copper(I) center to affect DNA function, showing inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris(triphenylphosphine)copper is promising for research of antibacterial, antitumor, and antioxidant agents.
    Chlorotris(triphenylphosphine)copper
  • HY-N8263
    Nepetoidin B
    Inhibitor
    Nepetoidin B, an anti-inflammatory agent, inhibits inflammation by modulating the NF-κB and Nrf2/HO-1 signaling pathways. Nepetoidin B also has antifungal and antibacterial activity. Nepetoidin B is a natural product that can be obtained from Salvia plebeia R. Br. Nepetoidin B can be used in anti-inflammatory and anti-infectious research.
    Nepetoidin B
  • HY-146116
    Antifungal agent 32
    Inhibitor
    Antifungal agent 32 (compound 1a) is a potent antifungal agent. Antifungal agent 32 inhibits Candida albicans filamentation and biofilm formation. Antifungal agent 32 inhibits the morphological switching of Candida albicans and its adherence to epithelial cells. Antifungal agent 32 can be used for Candida albicans infections research.
    Antifungal agent 32
  • HY-N0954
    (+)-Pinoresinol diacetate
    Inhibitor
    (+)-Pinoresinol diacetate is an antifungal agent that can be isolated from Sambucus williamsii.
    (+)-Pinoresinol diacetate
Cat. No. Product Name / Synonyms Application Reactivity