Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (2163)
Antibodies (1)
Related Compound Screening Libraries (1)

By Effects:	Controls (3) Inhibitors (1949) Antagonists (3) Modulators (2) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-Y0569BR

D-Gluconic acid calcium hydrate (Standard)	Inhibitor
D-Gluconic acid (calcium hydrate) (Standard) is the analytical standard of D-Gluconic acid (calcium hydrate). This product is intended for research and analytical applications. D-Gluconic acid calcium hydrate is the carboxylic acid by the oxidation with antiseptic and chelating properties.

HY-163979

Antifungal agent 109	Inhibitor
Antifungal agent 109 (compound F) is a spirothiazolidinone compound with antifungal activity, with an inhibition zone of 10-17 mm.

HY-B1444R

Isoconazole nitrate (Standard)	Inhibitor
Isoconazole (nitrate) (Standard) is the analytical standard of Isoconazole (nitrate). This product is intended for research and analytical applications. Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential.

HY-N0957

(±)-Pinoresinol	Inhibitor
(±)-Pinoresinol is a potent antifungal agent. (±)-Pinoresinol shows antifungal activity.

HY-130765

Ferbam	Inhibitor
Ferbam (Iron(III) dimethyldithiocarbamate) is a potent fungicide.

HY-149492

Phosphatase-IN-1	Inhibitor
Phosphatase-IN-1 (compound II-8), a propranolol (HY-B0573B) derivative, is a phosphatidate phosphatase (Pah) inhibitor. Phosphatase-IN-1 can binds to MoPah1, with an affinity constant of 19.8 μM. Phosphatase-IN-1 inhibits growth of plant pathogens and shows anti-fungal ability. Phosphatase-IN-1 is not toxic to rice seedlings and wheat heads.

HY-147238

Antifungal agent 35	Inhibitor
Antifungal agent 35 (compound 24) is a potent antifungal agent. Antifungal agent 35 is a potent enhancer of antifungal activity of Fluconazole against C. albicans.

HY-W505771

Seselin	Inhibitor	99.55%
Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active.

HY-153623

Antifungal agent 58	Inhibitor
Antifungal agent 58 (compound A21) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 58 is more effective than Miconazole (HY-B0454). Antifungal agent 58 inhibits Candida albicans strains with MIC values of 0.06-8 μg/mL.

HY-P2098

Alamethicin F 50	Inhibitor
Alamethicin F 50 is an antibiotic. Alamethicin F 50 is composed of membrane-active peptide, containing 75% Alamethicin F 50/5 and 10% Alamethicin F 50/7. Alamethicin F 50 is exhibits antifungal and antibacterial activity by disrupting the integrity of microbial cell membranes, resulting in leakage of cell contents and death of the microorganisms. Alamethicin F 50 is able to reduce the surface tension of water, which can be used as a surfactant or detergent.

HY-W750064

Acetophenone-¹³C₈
Acetophenone-¹³C₈ (1-Phenylethan-1-One-¹³C₈) is the ¹³C-labeled Acetophenone (HY-Y0989). Acetophenone (1-Phenylethan-1-One) is an organic compound with simple structure. Acetophenone can be bioreduced to phenylethanol (PEA).

HY-W016867R

4-Chlorosalicylic acid (Standard)	Inhibitor
4-Chlorosalicylic acid (Standard) is the analytical standard of 4-Chlorosalicylic acid. This product is intended for research and analytical applications. 4-Chlorosalicylic acid is a pharmaceutical intermediate. Inhibits monophenolase and diphenolase activity with IC50s of 1.89 mM and 1.10 mM. Potent antimicrobial activity. Against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.

HY-123351

Kievitone	Inhibitor
Kievitone, an isoflavanone, could be isolated from hypocotyls of Phaseolus vulgaris L. infected with Rhizoctonia solani Kühn. Kievitone has antifungal activity and antitumor activity.

HY-N6783

Oligomycin C	Inhibitor
Oligomycin C is a macrolide antibiotic produced by Streptomyces strains. Oligomycin C exhibits a strong activity against Aspergillus niger, Alternaria alternata, Botrytis cinerea and Phytophthora capsici but no activity toward bacteria.

HY-W040129R

Chromomycin A3 (Standard)	Inhibitor
Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 (HY-W040129). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg²⁺. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe.

HY-115946

Complex III-IN-2	Inhibitor
Complex III-IN-2 (Compd 4d-2) is a complex III inhibitor. Complex III-IN-2 shows antifungal activity with an EC₅₀ of 29.98 mg/L and 29.31 mg/L against sclerotinia sclerotiorum and R. solani, respectively.

HY-115945

Complex III-IN-1	Inhibitor
Complex III-IN-1 (Compd 4c-2) is a complex III inhibitor. Complex III-IN-1 shows antifungal activity with an EC₅₀ of 18.53 mg/L against sclerotinia sclerotiorum.

HY-16560R

Camptothecin (Standard)	Inhibitor
Camptothecin (Standard) (Campathecin (Standard)) is the analytical standard of Camptothecin (HY-16560). This product is intended for research and analytical applications. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.

HY-158053

Antifungal agent 94	Inhibitor
Antifungal agent 94 (Compound 49) is a Flavonoid derivative, which exhibits antifungal activity with EC₅₀ of 0.28 μM and a half-maximal effective concentration of 0.46 μg/mL against Rhizoctonia solani.

HY-B1814

Vitamin K5	Inhibitor
Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC₅₀ values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages.

Antifungal Compound Library

Compound library containing all kinds of molecules with anti-fungal activity.

436compounds HY-L048

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Fungal

Fungal

Fungal Related Products (2163)

Antibodies (1)

Related Compound Screening Libraries (1)

Fungal Related Products (2163):