2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-153621
    Antifungal agent 56
    		Inhibitor
    Antifungal agent 56 (compound A09) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 56 is more effective than Miconazole (HY-B0454). Antifungal agent 56 inhibits Candida albicans strains with MIC values of 0.03-0.25 μg/mL.
    Antifungal agent 56
  • HY-145407
    16,17-Dihydroheronamide C
    		Inhibitor
    16,17-Dihydroheronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C.
    16,17-Dihydroheronamide C
  • HY-B0139R
    Flucytosine (Standard)
    		Inhibitor
    Flucytosine (Standard) is the analytical standard of Flucytosine. This product is intended for research and analytical applications. Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells.
    Flucytosine (Standard)
  • HY-157018
    Antifungal agent 82
    		Inhibitor
    Antifungal agent 82 (compound G34) is a antifungal agent. Antifungal agent 82 exhibits excellent in vitro antifungal activity against Valsa mali, with an EC50 of 0.57 μg/mL. Antifungal agent 82 also exhibits excellent in vivo protective effects against V. mali at 40 μg/mL.
    Antifungal agent 82
  • HY-124408
    Mepronil
    		Inhibitor
    Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection.
    Mepronil
  • HY-P1508
    Bactenecin
    		Inhibitor
    Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei.
    Bactenecin
  • HY-156281
    Antifungal agent 76
    		Inhibitor
    Antifungal agent 76 (compound 23h) exhibits potent activities and a broad antifungal spectrum with low MICs of 0.25-16 μg/mL. Antifungal agent 76 might achieve its rapid fungicidal activity by disrupting the fungal cell membrane.
    Antifungal agent 76
  • HY-P11177
    Cn-AMP1
    		Inhibitor
    Cn-AMP1 is a disulfide-free plant peptide isolated from green coconut water. Cn-AMP1 shows activity against multiple pathogenic bacteria, fungal pathogens and cancer cells. Cn-AMP1 is capable of up-regulating inflammatory-cytokine secretion by monocytes. Cn-AMP1 can be used for research on control bacterial infections and cancers.
    Cn-AMP1
  • HY-W004282R
    Undecanoic acid (Standard)
    		Inhibitor
    Undecanoic acid (Standard) (Undecanoate (Standard)) is the analytical standard of Undecanoic acid (HY-W004282). This product is intended for research and analytical applications. Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum.
    Undecanoic acid (Standard)
  • HY-152136
    Antituberculosis agent-6
    		Inhibitor
    Antituberculosis agent-6 (compound 9g) is a potent antimycobacterial agent. Antituberculosis agent-6 shows significant activity against M. tuberculosis, with a MIC of 3.49 μM. Antituberculosis agent-6 also shows good antifungal activity against A. niger, with a MIC of 62.50 μM. Antituberculosis agent-6 shows high GI absorption.
    Antituberculosis agent-6
  • HY-155131
    Y18501
    		Inhibitor
    Y18501 is a oxysterol-binding protein (OSBPI) inhibitor with a similar structure to Oxathiapiprolin. Y18501 shows strong inhibitory activities against Phytophthora spp. and Pseudoperonospora cubensis, with EC50 ranging from 0.0005 to 0.0046 μg/mL. Y18501 shows excellent protective and curative activities against P. cubensis. Y18501 in combination with Chlorothalonil (HY-N6625) can significantly promote the inhibition of P. cubensis.
    Y18501
  • HY-W671129
    Frenolicin B
    		Inhibitor
    Frenolicin B is an antibioti with antifungal and mycoplasma activities.
    Frenolicin B
  • HY-N9711
    1-Methoxyberberine chloride
    		Inhibitor
    1-Methoxyberberine chloride is a plant alkaloid that can be found in Corydalis longipes. 1-Methoxyberberine chloride exhibits antifungal effects.
    1-Methoxyberberine chloride
  • HY-145407A
    ent-Heronamide C
    		Inhibitor
    ent-Heronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C.
    ent-Heronamide C
  • HY-163337
    Antifungal agent 92
    		Inhibitor
    Antifungal agent 92 (Compound 21) is a potent antifungal agent with an EC50 of 4.4 μM against Sclerotinia sclerotiorum. Antifungal agent 92 can induce abnormal mitochondrial morphology, loss of mitochondrial membrane potential, and reactive oxygen species (ROS) accumulation in Sclerotinia sclerotiorum. Antifungal agent 92 is a moderate promiscuous inhibitor of mitochondrial complexes II and III.
    Antifungal agent 92
  • HY-148968
    Metham sodium
    		Inhibitor
    Metham sodium (Carbathion) is a broad-spectrum soil microbial suppressant. Metham sodium controls soil-borne pests and weeds. Metham sodium inhibits weed seeds, plant-parasitic nematodes, plant pathogenic fungi and soil insects.
    Metham sodium
  • HY-139839
    Y12196
    Y12196 is a novel succinate dehydrogenase inhibitor (SDHI) which exhibits strong fungicidal activity against F. graminearum.
    Y12196
  • HY-D0008
    Brilliant green
    		Inhibitor
    Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal parasites and fungus. Brilliant green is effective against Gram-positive bacteria.
    Brilliant green
  • HY-N16053
    Antibacterial agent 288
    		Inhibitor
    Antibacterial agent 288 (Compound 1) has antibacterial and antifungal activities. Antibacterial agent 288 can be isolated from Mangrove fungus (No. B60) from the South China Sea.
    Antibacterial agent 288
  • HY-12613
    2-C-methylene-myo-inositol oxide
    2-C-methylene-myo-inositol oxide (NSC 45109), an inositol derivative, induces pseudohyphae formation in Saccharomyces spp.
    2-C-methylene-myo-inositol oxide
Cat. No. Product Name / Synonyms Application Reactivity