2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-E70120
    Phosphomannose isomerase
    Phosphomannose isomerase is the first enzyme involved in the biosynthesis pathway of GDP-Man. Phosphomannose isomerase catalyzes the conversion between fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P). Phosphomannose isomerase is important for cell wall synthesis and protein glycosylation. Phosphomannose isomerase is a potent antifungal target to curb the threats posed by A. flavus.
    Phosphomannose isomerase
  • HY-N1049
    Zeorin
    		Inhibitor
    Zeorin is a compound isolated from the lichen Parmotrema sancti-angelii.
    Zeorin
  • HY-158321
    SDH-IN-15
    		Inhibitor
    SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC50=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death.
    SDH-IN-15
  • HY-145873
    BI-10
    BI-10 is an antifungal compound. BI-10 combined with Fluconazole can inhibit hyphal growth, result in ROS accumulation, and decrease mitochondrial membrane potential (MMP) as well as altering membrane permeability.
    BI-10
  • HY-N2573
    Corydalmine
    		Inhibitor
    Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.
    Corydalmine
  • HY-109706
    (Rac)-CPI-098
    		Inhibitor
    (Rac)-CPI-098 shows antibacterial activity. (Rac)-CPI-098 exhibits superior anti-fungal activity against Monascus ruber, better activity against Aspergillus fumigates, good activity against Aspergillus niger and Aspergillus parasites and moderate activity against Candida albicans.
    (Rac)-CPI-098
  • HY-155004
    SDH-IN-3
    		Inhibitor
    SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 7.2 μg/mL. SDH-IN-3 exhibits excellent antifungal activities against Nigrospora oryzae with an EC50 of 1.9 μg/mL. SDH-IN-3 can be used for anti-infection research.
    SDH-IN-3
  • HY-126559
    Ansatrienin A
    		Inhibitor
    Ansatrienin A is an antifungal antibiotic that can be isolated from Streptomyces collinus.
    Ansatrienin A
  • HY-N6687B
    Calcimycin hemimagnesium
    		Inhibitor
    Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis.
    Calcimycin hemimagnesium
  • HY-N2519
    (E)-Coniferin
    		Inhibitor
    (E)-Coniferin is the isomer of Coniferin. Coniferin is a glucoside of coniferyl alcohol. Coniferin inhibits fungal growth and melanization.
    (E)-Coniferin
  • HY-B0851
    Triadimenol
    		Inhibitor 99.78%
    Triadimenol is a triazole fungicide and has been widely used in agriculture. Triadimenol has certain toxicity to animals.
    Triadimenol
  • HY-147805
    SARS-CoV-2 3CLpro-IN-4
    		Inhibitor
    SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities.
    SARS-CoV-2 3CLpro-IN-4
  • HY-N10289
    Cytosporone C
    Cytosporone C is an antifungal metabolite from the Melia azedarach-Associated Fungus Diaporthe eucalyptorum. Cytosporone C exhibits antifungal activities against Alternaria solani.
    Cytosporone C
  • HY-151566
    Antifungal agent 46
    		Inhibitor
    Antifungal agent 46 (compound 2f) is a potent antifungal agent. Antifungal agent 46 prevents Ras signaling by inhibiting protein farnesyltransferase.
    Antifungal agent 46
  • HY-148294
    Monogalactosyl diglyceride
    		Inhibitor
    Monogalactosyl diglyceride is a antimicrobial. Monogalactosyl diglyceride has antibacterial activity and antifungal activity in vitro.
    Monogalactosyl diglyceride
  • HY-162296
    Antibacterial agent 188
    		Inhibitor
    Antibacterial agent 188 (compound 2d) is an antibacterial agent that inhibits dermatophyte activity.
    Antibacterial agent 188
  • HY-120183
    Harzianopyridone
    		Inhibitor
    Harzianopyridone is a compound that can be isolated from Trichoderma harzianum. Harzianopyridone is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 80 nM. Harzianopyridone has antifungal, antibacterial, and herbicidal activities.
    Harzianopyridone
  • HY-W115276
    Fenticonazole
    Fenticonazole is an imidazole derivative with antibacterial and antifungal activity. Fenticonazole has the potential for the research of mixed vaginitis.
    Fenticonazole
  • HY-W004282S2
    Undecanoic acid-d2
    		Inhibitor
    Undecanoic acid-d2 (Undecanoate-d2) is the deuterium labeled Undecanoic acid (HY-W004282). Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum.
    Undecanoic acid-d<sub>2</sub>
  • HY-133537
    Hygrolidin
    		Inhibitor
    Hygrolidin is a 16-membered macrolide antibiotic produced by Streptomyces hygroscopicus D-1166. Hygrolidin has anti-fungus activity against Valsa ceratosperma. Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Hygrolidin has antitumor activity.
    Hygrolidin
Cat. No. Product Name / Synonyms Application Reactivity