2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112176R
    Kanosamine hydrochloride (Standard)
    		Inhibitor
    6-Hydroxytropinone (Standard) is the analytical standard of 6-Hydroxytropinone. This product is intended for research and analytical applications. 6-Hydroxytropinone is a Alkaloids product that can be isolated from the roots of Atropa belladonna.
    Kanosamine hydrochloride (Standard)
  • HY-162687
    Antibacterial agent 232
    		Inhibitor
    Antibacterial agent 232 (compound Y41) is a potent antibacterial agent. Antibacterial agent 232 disrupts the cell membrane integrity by inducing cell peroxidation.
    Antibacterial agent 232
  • HY-W164451
    N-(2-hydroxy-2-phenylethyl)acetamide
    N-(2-hydroxy-2-phenylethyl)acetamide is isolated from the solid rice cultures of the endophytic fungus Diaporthe eucalyptorum KY-9. N-(2-hydroxy-2-phenylethyl)acetamide exhibits antifungal activities against Alternaria solani.
    N-(2-hydroxy-2-phenylethyl)acetamide
  • HY-N1944S
    Nerolidol-d4
    		Inhibitor
    Nerolidol-d4 is deuterated labeled Nerolidol (HY-N1944). Nerolidol has multiple natural membrane activities, possesses anti-cancer, anti-inflammatory, antibacterial and anti-insect activity. Nerolidol Suppresses parasitic activity, suppresses bloodsucking diseases, bloodworm diseases, and other diseases. Nerolidol can protect the cells from lipid and protein properties, damage to DNA, and protect the cells from damage.
    Nerolidol-d<sub>4</sub>
  • HY-118216
    Bitertanol
    		Inhibitor
    Bitertanol (Biloxazol) is a potent antifungal agent. Bitertanol also is an CYP1A1, CYP2B, and CYP3A inducer in vivo and an CYP1A inhibitor in vitro.
    Bitertanol
  • HY-W739754
    Ergosterol acetate
    Ergosterol acetate is a natural compound that can be isolated from fungi.
    Ergosterol acetate
  • HY-155703
    LW3
    		Inhibitor 99.87%
    LW3 is a potent antifungal agent. LW3 has antifungal activity with EC50 values of 0.54, 0.09, 1.52, and 2.65 mg/L against B. cinerea, R. solani, S. sclerotiorum, and F. graminearum, respectively.
    LW3
  • HY-135761R
    Penconazole (Standard)
    		Inhibitor
    Penconazole (Standard) is the analytical standard of Penconazole. This product is intended for research and analytical applications. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.
    Penconazole (Standard)
  • HY-Y1250S4
    Fmoc-Gly-OH-1-13C
    		Inhibitor
    Fmoc-Gly-OH-1-13C is a 13C-labeled Fmoc-Gly-OH (HY-Y1250). Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds.
    Fmoc-Gly-OH-1-<sup>13</sup>C
  • HY-123230R
    Trifloxystrobin (Standard)
    		Inhibitor
    Trifloxystrobin (Standard) is the analytical standard of Trifloxystrobin. This product is intended for research and analytical applications. Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases.
    Trifloxystrobin (Standard)
  • HY-155769
    Antimicrobial agent-24
    		Inhibitor
    Antimicrobial agent-24 (compound E8) is a hydrazide compound with excellent and broad-spectrum fungicidal activities. Antimicrobial agent-24 affects the normal function of the plasma membrane, further generating changes in the morphology and subcellular structure of mycelia.
    Antimicrobial agent-24
  • HY-N10272
    Avenaciolide
    		Inhibitor
    Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation.
    Avenaciolide
  • HY-B1729S1
    Phenoxyethanol-d4
    		Inhibitor
    Phenoxyethanol-d4 is the deuterium labeled Phenoxyethanol. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al.
    Phenoxyethanol-d<sub>4</sub>
  • HY-N7682
    β-Tomatine
    		Inhibitor
    β-Tomatine is a breakdown product of α-tomatine and a less fungitoxic compound. β-Tomatine can suppress plant defense responses.
    β-Tomatine
  • HY-130047
    Bivittoside A
    Bivittoside A is a non-sulfated hexoside analog derived from Bovine sea cucumber, exhibiting antifungal properties and potential for antitumor applications.
    Bivittoside A
  • HY-17583S1
    Griseofulvin-13C,d3
    		Inhibitor
    Griseofulvin-13C,d3 is the 13C- and deuterium labeled Griseofulvin.
    Griseofulvin-<sup>13</sup>C,d<sub>3</sub>
  • HY-156151
    CYP51/PD-L1-IN-3
    		Inhibitor
    CYP51/PD-L1-IN-3 (compound L21) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-3 is a dual inhibitor of CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-3 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death.
    CYP51/PD-L1-IN-3
  • HY-W705792
    Ethaboxam-d5
    Ethaboxam-d5 (Intego solo-d5) is the deuterium labeled Ethaboxam (HY-107492). Ethaboxam is a β-tubulin inhibitor that can be used as anti-oomycete fungicide.
    Ethaboxam-d<sub>5</sub>
  • HY-W391625
    (Rac)-Dehydrocostus Lactone
    		99.91%
    (Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index.
    (Rac)-Dehydrocostus Lactone
  • HY-152909
    Nystatin A2
    		Inhibitor
    Nystatin A2 is an active component of antifungal agent, Nystatin (HY-17409). Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma.
    Nystatin A2
Cat. No. Product Name / Synonyms Application Reactivity