2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N5085
    Nudicaucin B
    		Inhibitor
    Nudicaucin B is a triterpenoid saponi found in Hedyotis nudicaulis. Nudicaucin B has antifungal activities.
    Nudicaucin B
  • HY-169751
    Dihydro-N-caffeoyltyramine
    		Inhibitor
    Dihydro-N-caffeoyltyramine is a new phenolic amide that can be isolated from the root bark of wolfberry and has strong antioxidant activity and antifungal effects. Dihydro-N-caffeoyltyramine downregulates the expression of cyclooxygenase-2 by inhibiting the activity of C/EBP and AP-1 transcription factors.
    Dihydro-N-caffeoyltyramine
  • HY-149614
    Laccase-IN-1
    		Inhibitor
    Laccase-IN-1 (compound 4b) is an orally active inhibitor of laccase, with the IC50 of 11.3 μM. Laccase-IN-1displays protective and curative effects on apple fruits infected by B. dothidea. Laccase-IN-1 enhances the cell membrane permeability, destroys the mycelial surface morphology and the cell ultrastructure, and reduces the ergosterol and exopolysaccharide contents of B. dothidea.
    Laccase-IN-1
  • HY-N6032
    Esculentoside B
    		Inhibitor
    Esculentoside B (Phytolaccoside B) is a natural product from the roots of Phytolacca acinosa Roxb. Esculentoside B is neurotoxic to zebrafish larvae, and impairs their central nervous system development. Esculentoside B inhibits inflammatory response and has antifungal activity.
    Esculentoside B
  • HY-W715372R
    Pyraoxystrobin (Standard)
    		Inhibitor
    Pyraoxystrobin (Standard) is the analytical standard of Pyraoxystrobin. This product is intended for research and analytical applications. Pyraoxystrobin is a QoI fungicide, with an EC50 of 0.0094 μg/mL for M. oryzae isolates. Pyraoxystrobin can be used for the research of M. oryzae in rice fields.
    Pyraoxystrobin (Standard)
  • HY-139713
    Antifungal agent 14
    		Inhibitor
    Antifungal agent 14 exhibits broad-spectrum activity against the fungal strains with excellent minimum inhibitory concentration values.
    Antifungal agent 14
  • HY-P11176
    Coccinin
    		Inhibitor
    Coccinin is an antifungal peptide. Coccinin can be purified from the seeds of large scarlet runner beans. Coccinin inhibits HIV-1 reverse transcriptase. Coccinin shows antifungal activity against M. arachidicola, F. oxysporum, P. piricola, B. cinerea, C. comatus and R. solani, with IC50s of 75, 81, 89, 109, 122 and 134 μM, respectively.
    Coccinin
  • HY-106141
    Albaconazole
    		Inhibitor
    Albaconazole (UR 9825) is a broad-spectrum triazole and oral activity antifungal agent.
    Albaconazole
  • HY-P10329
    KK14(R)
    		Inhibitor
    KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7.
    KK14(R)
  • HY-P5572
    Aurein 2.5
    		Inhibitor
    Aurein 2.5 is an antibiotic antimicrobial peptide. Aurein 2.5 has antibacterial and antifungal activity
    Aurein 2.5
  • HY-143232
    Antibacterial agent 73
    		Inhibitor
    Antibacterial agent 73 (compound 7a) is a potent antimicrobial agent. Antibacterial agent 73 exhibits very good antitubercular activity (MIC=0.65 µg/mL) against Mtb H37Rv. Antibacterial agent 73 shows good activity against fungal and bacterial. Antibacterial agent 73 also shows cytotoxicity in MCF-7 breast cancer cell lines, with IC50 of 8.20 μM.
    Antibacterial agent 73
  • HY-N10971
    Noraucuparin
    		Inhibitor
    Noraucuparin is a biphenyl-type phytoalexin. Noraucuparin has antifungal effect. Noraucuparin can be isolated from the leaves of Sorbus pohuashanensis.
    Noraucuparin
  • HY-19584
    Variotin
    		Inhibitor
    Variotin is an Anti-Fungal Agent. Variotin has a strong antibiotic activity on dermatophytes such as Trichophyton, Microsporum, and Epidermophyton, and also pathogenic fungi in internal mycosis such as Blastomyces and Cryptococcus.
    Variotin
  • HY-N0068R
    Solasodine (Standard)
    		Inhibitor
    Solasodine (Standard) is the analytical standard of Solasodine. This product is intended for research and analytical applications. Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities.
    Solasodine (Standard)
  • HY-B2067S
    Cymoxanil-d3
    		Inhibitor
    Cymoxanil-d3 is the deuterium labeled Cymoxanil (HY-B2067). Cymoxanil is a fungicidal cyanooxime against plant diseases caused by fungi belonging to the Perenosporales. Cymoxanil affects growth, DNA and RNA synthesis in Phytophthora.
    Cymoxanil-d<sub>3</sub>
  • HY-149601
    SDH-IN-8
    		Inhibitor
    SDH-IN-8 (compound G40) is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 27 nM for porcine SDH. SDH-IN-8 has fungicidal properties.
    SDH-IN-8
  • HY-N0540R
    Cynaroside (Standard)
    		Inhibitor
    Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities.
    Cynaroside (Standard)
  • HY-B0896S2
    Triacetin-d9
    Glyceryl Triacetate-d9 is the deuterium labeled Triacetin. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
    Triacetin-d<sub>9</sub>
  • HY-N16451
    Asperindole E
    Asperindole E is an indole-diterpene alkaloid that can be isolated from the coral-associated fungi Aspergillus candidus. Asperindole E exhibits no significant regulatory activity in the model of primary cultured cortical neuronal hyperexcitation.
    Asperindole E
  • HY-W042156R
    Aegeline (Standard)
    Aegeline (Standard) is the analytical standard of Aegeline. This product is intended for research and analytical applications. Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity.
    Aegeline (Standard)
Cat. No. Product Name / Synonyms Application Reactivity