2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N12697A
    Polycarpine hydrochloride
    		Inhibitor
    Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC50 = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC50 values of 30.0 nM and 0.12 μM against SARS-CoV-2 Mpro and PEDV Mpro, respectively.
    Polycarpine hydrochloride
  • HY-165142
    Aureonitol
    Aureonitol is a compound isolated from fungi that has anti-influenza activity by inhibiting the surface glycoprotein hemagglutinin of influenza virus and has potential value for compound development.
    Aureonitol
  • HY-125682
    Amphotericin A
    Amphotericin A is a potent antifungal antibiotic.
    Amphotericin A
  • HY-N8537R
    Enfumafungin (Standard)
    		Inhibitor
    Enfumafungin (Standard) is the analytical standard of Enfumafungin. This product is intended for research and analytical applications. Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis[1][2].
    Enfumafungin (Standard)
  • HY-156150
    CYP51/PD-L1-IN-2
    		Inhibitor
    CYP51/PD-L1-IN-2 (compound L20) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-2 is a dual inhibitor of CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-2 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death.
    CYP51/PD-L1-IN-2
  • HY-121109S
    Benalaxyl-d5
    		Inhibitor
    Benalaxyl-d5 is the deuterium labeled Benalaxyl (HY-121109). Benalaxyl is a fungicide, but A. fumigatus isolates are intrinsically resistant to Benalaxyl.
    Benalaxyl-d<sub>5</sub>
  • HY-W042181S
    N-Decyl-N,N-dimethyldecan-1-aminium-d6 chloride
    		Inhibitor
    N-Decyl-N,N-dimethyldecan-1-aminium-d6 (chloride) is a deuterated labeled N-Decyl-N,N-dimethyldecan-1-aminium (chloride). N-Decyl-N,N-dimethyldecan-1-aminium chloride (Didecyldimethylammonium chloride) is a dialkyl-quaternary ammonium compound that is used in numerous products for its bactericidal, virucidal and fungicidal properties.
    N-Decyl-N,N-dimethyldecan-1-aminium-d<sub>6</sub> chloride
  • HY-N10269
    Phomalactone
    		Inhibitor
    Phomalactone, produced by the fungus Nigrospora sphaerica, specifically inhibits the mycelial growth of Phytophthora infestans, with an MIC value of 2.5 mg/L. Phomalactone is phytotoxic to Z. elegans and other plant species by inhibition of seedling growth and by causing electrolyte leakage from photosynthetic tissues of both Z. elegans leaves and cucumber cotyledons.
    Phomalactone
  • HY-N11706
    β-Cedrene
    		Inhibitor
    β-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a Ki value of 1.6 μM.
    β-Cedrene
  • HY-169252
    Antifungal agent 121
    		Inhibitor
    Antifungal agent 121 (compound TM11) is a fungicide. The chemical nature of Antifungal agent 121 is a benzimidazole-acrylonitrile derivative.
    Antifungal agent 121
  • HY-159486
    SDH-IN-18
    		Inhibitor
    SDH-IN-18 (Compound 3a) is an inhibitor for succinate dehydrogenase (SDH) with an IC50 of 8.70 mg/L. SDH-IN-18 destroys fungal morphology and reproduction, exhibits antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum with EC50 of 0.48 and 1.4 mg/L.
    SDH-IN-18
  • HY-151459
    VEGFR-2/DHFR-IN-2
    		Inhibitor
    VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer.
    VEGFR-2/DHFR-IN-2
  • HY-N9370
    Isobellidifolin
    		Inhibitor
    Isobellidifolin, a xanthone, is a free radical scavenger and antioxidant compound. Isobellidifolin has potent antifungal effect.
    Isobellidifolin
  • HY-N9068
    Alterlactone
    		Inhibitor
    Alterlactone is an antimicrobial. Alterlactone shows broad antimicrobial activity against bacterial and fungal. Alterlactone has strong radical scavenging activity.
    Alterlactone
  • HY-155545
    Antifungal agent 60
    		Inhibitor
    Antifungal agent 60 (compound 16) is an inhibitor of ergosterol biosynthesis with broad-spectrum antifungal activity. Antifungal agent 60 inhibits 7 human pathogenic fungal species, 2 fluconazole-resistant C. albicans isolates and 2 multi-drug resistant Candida auris isolates. Antifungal agent 60 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Antifungal agent 60
  • HY-162648
    Succinate dehydrogenase-IN-1
    		Inhibitor
    Succinate dehydrogenase-IN-1 (Compound 34) is an inhibitor for succinate dehydrogenase (SDH) with an IC50 of 0.94 μM and a KD of 22.4 μM. Succinate dehydrogenase-IN-1 exhibits antifungal activity against Rhizoctonia solani, Sclerotinia sclerotiorum, Monilinia fructicola, and Botrytis cinerea, with EC50 of 0.04 μM, 1.13 μM, 1.61 μM and 1.21 μM, respectively.
    Succinate dehydrogenase-IN-1
  • HY-108422R
    Benodanil (Standard)
    		Inhibitor
    Benodanil (Standard) is the analytical standard of Benodanil. This product is intended for research and analytical applications. Benodanil (NSC 100499) is a group of benzanilide fungicide, is used extensively in agriculture.
    Benodanil (Standard)
  • HY-150972
    P163-0892
    		Inhibitor
    P163-0892 is a potent and selective antifungal agent against Cryptococcus species. P163-0892 is predicted to show medium BBB penetration.
    P163-0892
  • HY-122245
    Sortin2
    		Inhibitor
    Sortin2 is a synthetic compound and a Yeast vacuolar protein sorting (vps) inhibitor . Sortin2 can affect protein targeting to the vacuole in Saccharomyces cerevisiae.
    Sortin2
  • HY-B0846S
    Dimethomorph-d8
    Dimethomorph-d8 is the deuterium labeled Dimethomorph. Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 μM.
    Dimethomorph-d<sub>8</sub>
Cat. No. Product Name / Synonyms Application Reactivity