2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0404R
    Sinigrin (Standard)
    		Inhibitor
    Sinigrin (Standard) (Allyl-glucosinolate (Standard)) is the analytical standard of Sinigrin (HY-N0404). This product is intended for research and analytical applications. Sinigrin (Allyl-glucosinolate) is an orally active glucosinolate found in cruciferous plants. Sinigrin possesses multiple activities such as anti-cancer, antibacterial, antifungal, anti-inflammatory, antioxidant, and inhibition of fat synthesis. Sinigrin can be used in the research of tumors, inflammatory, and metabolic diseases.
    Sinigrin (Standard)
  • HY-118847
    Antifungal agent 86
    		Inhibitor
    Antifungal agent 86 (Compound 41F5) is an antifungal agent. Antifungal agent 86 is highly active against Histoplasma yeast and Cryptococcus neoformans (MIC50: 0.4-0.8 μM).
    Antifungal agent 86
  • HY-161312
    Antifungal agent 93
    		Inhibitor
    Antifungal agent 93 (compound 10) is a potent antifungal agent. Antifungal agent 93 shows antimicrobial activity.
    Antifungal agent 93
  • HY-122298
    Fenpicoxamid
    		Inhibitor
    Fenpicoxamid is a new fungicide. Fenpicoxamid inhibits the growth of the fungus Z. tritici with an EC50 value of 0.051 mg/L.
    Fenpicoxamid
  • HY-P2302
    Defensin HNP-3 human
    		Inhibitor
    Defensin HNP-3 human is a cytotoxic antibiotic peptide known as "defensin". Defensin HNP-3 human has inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. Defensin HNP-3 human is initially synthesized as the 94 amino acids preproHNP(1-94), which is hydrolyzed to proHNP(20-94) and converted to mature HNP(65-94) after the removal of anion precursors.
    Defensin HNP-3 human
  • HY-N12122
    Dehydropipernonaline
    		Inhibitor
    Dehydropipernonaline (Compound 24) is an amide compound. Dehydropipernonaline shows considerable cytotoxicity to L5178Y mouse lymphoma cells (IC508.9μM). Dehydropipernonaline can be used for screening antifungal and cytotoxicity .
    Dehydropipernonaline
  • HY-W596782
    Chaetochromin A
    Chaetochromin A (Compound 1) is a fungal metabolite. Chaetochromin A shows inhibitory effect on botulinum neurotoxin serotype A (BoNT A) (IC50= 24.6 μM).
    Chaetochromin A
  • HY-N5085
    Nudicaucin B
    		Inhibitor
    Nudicaucin B is a triterpenoid saponi found in Hedyotis nudicaulis. Nudicaucin B has antifungal activities.
    Nudicaucin B
  • HY-169751
    Dihydro-N-caffeoyltyramine
    		Inhibitor
    Dihydro-N-caffeoyltyramine is a new phenolic amide that can be isolated from the root bark of wolfberry and has strong antioxidant activity and antifungal effects. Dihydro-N-caffeoyltyramine downregulates the expression of cyclooxygenase-2 by inhibiting the activity of C/EBP and AP-1 transcription factors.
    Dihydro-N-caffeoyltyramine
  • HY-149614
    Laccase-IN-1
    		Inhibitor
    Laccase-IN-1 (compound 4b) is an orally active inhibitor of laccase, with the IC50 of 11.3 μM. Laccase-IN-1displays protective and curative effects on apple fruits infected by B. dothidea. Laccase-IN-1 enhances the cell membrane permeability, destroys the mycelial surface morphology and the cell ultrastructure, and reduces the ergosterol and exopolysaccharide contents of B. dothidea.
    Laccase-IN-1
  • HY-N6032
    Esculentoside B
    		Inhibitor
    Esculentoside B (Phytolaccoside B) is a natural product from the roots of Phytolacca acinosa Roxb. Esculentoside B is neurotoxic to zebrafish larvae, and impairs their central nervous system development. Esculentoside B inhibits inflammatory response and has antifungal activity.
    Esculentoside B
  • HY-W715372R
    Pyraoxystrobin (Standard)
    		Inhibitor
    Pyraoxystrobin (Standard) is the analytical standard of Pyraoxystrobin. This product is intended for research and analytical applications. Pyraoxystrobin is a QoI fungicide, with an EC50 of 0.0094 μg/mL for M. oryzae isolates. Pyraoxystrobin can be used for the research of M. oryzae in rice fields.
    Pyraoxystrobin (Standard)
  • HY-139713
    Antifungal agent 14
    		Inhibitor
    Antifungal agent 14 exhibits broad-spectrum activity against the fungal strains with excellent minimum inhibitory concentration values.
    Antifungal agent 14
  • HY-106141
    Albaconazole
    		Inhibitor
    Albaconazole (UR 9825) is a broad-spectrum triazole and oral activity antifungal agent.
    Albaconazole
  • HY-P10329
    KK14(R)
    		Inhibitor
    KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7.
    KK14(R)
  • HY-P5572
    Aurein 2.5
    		Inhibitor
    Aurein 2.5 is an antibiotic antimicrobial peptide. Aurein 2.5 has antibacterial and antifungal activity
    Aurein 2.5
  • HY-143232
    Antibacterial agent 73
    		Inhibitor
    Antibacterial agent 73 (compound 7a) is a potent antimicrobial agent. Antibacterial agent 73 exhibits very good antitubercular activity (MIC=0.65 µg/mL) against Mtb H37Rv. Antibacterial agent 73 shows good activity against fungal and bacterial. Antibacterial agent 73 also shows cytotoxicity in MCF-7 breast cancer cell lines, with IC50 of 8.20 μM.
    Antibacterial agent 73
  • HY-N10971
    Noraucuparin
    		Inhibitor
    Noraucuparin is a biphenyl-type phytoalexin. Noraucuparin has antifungal effect. Noraucuparin can be isolated from the leaves of Sorbus pohuashanensis.
    Noraucuparin
  • HY-19584
    Variotin
    		Inhibitor
    Variotin is an Anti-Fungal Agent. Variotin has a strong antibiotic activity on dermatophytes such as Trichophyton, Microsporum, and Epidermophyton, and also pathogenic fungi in internal mycosis such as Blastomyces and Cryptococcus.
    Variotin
  • HY-N0068R
    Solasodine (Standard)
    		Inhibitor
    Solasodine (Standard) is the analytical standard of Solasodine. This product is intended for research and analytical applications. Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities.
    Solasodine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity