1. Signaling Pathways
  2. Anti-infection
  3. Fungal

Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-155669
    Antifungal agent 64
    Antifungal agent 64 (Compound 5c) is a fungicidal agent with excellent fungicidal activities against Fusarium oxysporum f.sp. cucumerinum. Antifungal agent 64 can be used for antiviral and fungicidal research.
    Antifungal agent 64
  • HY-149603
    Antifungal agent 78
    Inhibitor
    Antifungal agent 78 (compound 25am) is an antifungal agent with an EC50 value of 13.46 μM against F. graminearum.
    Antifungal agent 78
  • HY-N4283A
    (E)-Coniferyl alcohol
    Inhibitor 99.62%
    (E)-Coniferyl alcohol is the isomer of Coniferyl alcohol. Coniferyl alcohol is an intermediate in biosynthesis of eugenol and of stilbenoids and coumarin. Coniferyl alcohol specifically inhibits fungal growth.
    (E)-Coniferyl alcohol
  • HY-126461
    Salazinic acid
    Inhibitor
    Salazinic acid has antibacterial activity against bacteria and fungi. Salazinic acid does not show antibacterial activity against Listeria monocytogenes, Pseudomonas aeruginosa, Yersinia enterocolitica, and Enterococcus faecalis, but it does have antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium.
    Salazinic acid
  • HY-141812
    Antifungal agent 12
    Inhibitor
    Antifungal agent 12 is a novel fluconazole-based compound with promising antifungal activities.
    Antifungal agent 12
  • HY-W840250
    3,5-Dimethyl-4-phenylisoxazole
    Inhibitor
    3,5-Dimethyl-4-phenylisoxazole (3,5-Dimethyl-4-phenyl-1,2-oxazole) is a heterocyclic compound that serves as a molecular structural unit, exhibiting anti-inflammatory, anti-tumor, anti-bacterial, and anti-fungal properties, along with the capacity to modulate the immune system.
    3,5-Dimethyl-4-phenylisoxazole
  • HY-165128
    Alternapyrone
    Alternapyrone is an α-pyrone compound found in fungi, some of which are phytotoxic to wheat seed germination, and its biosynthesis requires only three enzymes.
    Alternapyrone
  • HY-163571
    CYP51-IN-17
    Inhibitor
    CYP51-IN-17 (compound 7a) is a potent CYP51 inhibitor with an IC50 of 0.377 μg/mL. CYP51-IN-17 shows significant fungicidal activity against B. cinerea with an EC50 of 0.326 μg/mL.
    CYP51-IN-17
  • HY-119606
    Bacimethrin
    Inhibitor
    Bacimethrin (NSC 66577) is an antibacterial agent and is thiamin biosynthesis antagonist.Bacimethrin inhibits bacterial and yeast growth.
    Bacimethrin
  • HY-P10538
    Balteatide
    Inhibitor
    Balteatide is an antimicrobial peptide, which can be found in skin secretion of Phyllomedusa baltea. Balteatide inhibits the gram-positive Staphylococcus aureus (MIC=435 μM), the gram-negative Escherichia coli (MIC=109 μM), and Candida albicans (MIC=27 μM). Balteatide lacks hemolytic activity (at 512 mg/L) and myotropic activity.
    Balteatide
  • HY-17594R
    Oxyclozanide (Standard)
    Inhibitor
    Oxyclozanide (Standard) is the analytical standard of Oxyclozanide. This product is intended for research and analytical applications. Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity.
    Oxyclozanide (Standard)
  • HY-B1134A
    Imazalil sulfate
    Inhibitor 99.63%
    Imazalil (Enilconazole) sulfate is a fungicide. Imazalil sulfate has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil sulfate is commonly used to protect various agricultural crops against fungal attack. Imazalil sulfate induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder.
    Imazalil sulfate
  • HY-N11506
    lsocryptomerin
    Inhibitor
    lsocryptomerin is a membrane-active antifungal compound that can be isolated from Selaginella tamariscina. lsocryptomerin can depolarize fungal plasma membrane. lsocryptomerin also shows anticancer and antibacterial activities.
    lsocryptomerin
  • HY-144643
    CYP51/HDAC-IN-1
    Inhibitor
    CYP51/HDAC-IN-1 is a potent, orally active CYP51/HDAC dual inhibitor. CYP51/HDAC-IN-1 inhibits important virulence factors and down-regulated resistance-associated genes. CYP51/HDAC-IN-1 exhibits potent therapeutic effects for both tropical candidiasis and cryptococcal meningitis.
    CYP51/HDAC-IN-1
  • HY-76200R
    Voriconazole (Standard)
    Inhibitor
    Voriconazole (Standard) is the analytical standard of Voriconazole. This product is intended for research and analytical applications. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.
    Voriconazole (Standard)
  • HY-124902
    Valclavam
    Inhibitor
    Valclavam is an antibiotic, which exhibits antibacterial and antifungal activities. Valclavam inhibits homoserine-O-succinyltransferase (EC 2.3.1.46), blocks the methionine synthesis, and thus inhibits Escherichia coli. Valclavam inhibits Saccharomyces cerevisiae through inhibition of RNA formation. Valclavam inhibits the movement and reproduction of nematode Caenorhabditis elegans.
    Valclavam
  • HY-163911
    SDH-IN-19
    Inhibitor
    SDH-IN-19 (compound A13) is a fungicide, with an EC50 value of 0.83 μg/mL against Rhizoctonia solani. SDH-IN-19 can be used in antifungal research of crops.
    SDH-IN-19
  • HY-152137
    Antituberculosis agent-7
    Inhibitor
    Antituberculosis agent-7, an oxetanyl-quinoline derivative, has shown good antibacterial activity against P. mirabilis with a MIC of 31.25 μM. Antituberculosis agent-7 shows good antifungal activity against A. niger with a MIC of 62.5 μM. Antituberculosis agent-7 shows excellent antimycobacterial activity with MIC 3.41 μM for M. tuberculosis H37Rv.
    Antituberculosis agent-7
  • HY-N0404R
    Sinigrin (Standard)
    Inhibitor
    Sinigrin (Standard) (Allyl-glucosinolate (Standard)) is the analytical standard of Sinigrin (HY-N0404). This product is intended for research and analytical applications. Sinigrin (Allyl-glucosinolate) is an orally active glucosinolate found in cruciferous plants. Sinigrin possesses multiple activities such as anti-cancer, antibacterial, antifungal, anti-inflammatory, antioxidant, and inhibition of fat synthesis. Sinigrin can be used in the research of tumors, inflammatory, and metabolic diseases.
    Sinigrin (Standard)
  • HY-118847
    Antifungal agent 86
    Inhibitor
    Antifungal agent 86 (Compound 41F5) is an antifungal agent. Antifungal agent 86 is highly active against Histoplasma yeast and Cryptococcus neoformans (MIC50: 0.4-0.8 μM).
    Antifungal agent 86
Cat. No. Product Name / Synonyms Application Reactivity