2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N1453R
    Hypocrellin B (Standard)
    		Inhibitor
    Hypocrellin B (Standard) is the analytical standard of Hypocrellin B. This product is intended for research and analytical applications. Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities[1][2][3].
    Hypocrellin B (Standard)
  • HY-N3296
    Meridinol
    		Inhibitor
    Meridinol ((-)-Meridinol) shows antimicrobial activity against a wide range of gram-positive and gram-negative bacteria and fungi.
    Meridinol
  • HY-150584
    Chitin synthase inhibitor 3
    		Inhibitor
    Chitin synthase inhibitor 3 (compound 2d) is a potent chitin synthase inhibitor with an IC50 value of 0.16 mM, and MIC of 1 µg/mL against candida albicans. Antifungal activity.
    Chitin synthase inhibitor 3
  • HY-N0571R
    Purpurin (Standard)
    		Inhibitor
    Purpurin (Standard) is the analytical standard of Purpurin. This product is intended for research and analytical applications. Purpurin is a natural anthraquinone compound from Rubia cordifolia L.. Purpurin has antidepressant-like effects.
    Purpurin (Standard)
  • HY-155279
    Antifungal agent 73
    		Inhibitor
    Antifungal agent 73 (compound A32) is an antifungal agent for azole-resistant candidiasis. Antifungal agent 73 disrupts the fungal cell wall and cell membrane. Antifungal agent 73 shows potent in vivo antifungal activity against pathogenic fungi and fluconazole-resistant strains.
    Antifungal agent 73
  • HY-161071
    Antioxidant/anticancer agent 1
    		Inhibitor
    Antioxidant/anticancer agent 1 (compound 5) is a pyrimidine-derivatized Schiff base based on pyrimidine hydroxy-1-naphthaldehyde and has antibacterial, antioxidant, antifungal, and anticancer properties. Antioxidant/anticancer agent 1.
    Antioxidant/anticancer agent 1
  • HY-159585
    CYP51-IN-20
    		Inhibitor
    CYP51-IN-20 (compound 5b) is an inhibitor of CYP51 and has antifungal activity. CYP51-IN-20 has a significant inhibitory effect on Candida albicans ATCC 10231, downregulates ERG11 (Cyp51) gene expression, and significantly reduces the yeast-to-hyphae morphological transition. CYP51-IN-20 can synergize with Voriconazole (HY-76200) to occupy the entire CYP51 binding site and exert a synergistic inhibitory effect in the Glechoma moth model.
    CYP51-IN-20
  • HY-121069
    Elubiol
    		98.69%
    Elubiol (Dichlorophenyl imidazoldioxolan) has moderate sebum-inhibiting activity and can be used in the treatment of oily skin or dandruff.
    Elubiol
  • HY-N3916
    Galanolactone
    		Inhibitor
    Galanolactone is a natural product that can be isolated from the seeds of Alpinia galanga. Galanolactone shows antifungal activitie. Galanolactone shows cytotoxicity against KB cells with an EC50 of 38.5 µg/ml.
    Galanolactone
  • HY-159104
    Cinnamon bark oil, from Cinnamonum zeylanicum Blume
    		Inhibitor
    Cinnamon bark oil, from Cinnamonum zeylanicum Blume is a antifungal agent against fungi causing respiratory tract mycoses.
    Cinnamon bark oil, from Cinnamonum zeylanicum Blume
  • HY-17029R
    Epothilone B (Standard)
    		Inhibitor
    Epothilone B (Standard) is the analytical standard of Epothilone B. This product is intended for research and analytical applications. Epothilone B is a microtubule stabilizer with a Ki of 0.71μM. It acts by binding to the αβ-tubulin heterodimer subunit which causes decreasing of αβ-tubulin dissociation.
    Epothilone B (Standard)
  • HY-N13154
    Malolactomycin C
    		Inhibitor
    Malolactomycin C (compound 1) is a macrolide antifungal antibiotic isolated from Streptomyces strain KP-3144. Malolactomycin C is an effective inhibitor of Botrytis cinerea and thus controls a variety of plant diseases including gray mold.
    Malolactomycin C
  • HY-149822
    Antifungal agent 51
    		Inhibitor
    Antifungal agent 51 (Compound 5c) has potent antifungal activity, especially against Candida albicans FDC 151 , Candida parapsilosis ATCC 22019 and Candida tropicalis FDC 138, with the MIC value is less than 0.063 μg/mL, and it has low toxicity to cells and no carcinogenicity.
    Antifungal agent 51
  • HY-B0736AR
    Sertaconazole nitrate (Standard)
    		Inhibitor
    Sertaconazole (nitrate) (Standard) is the analytical standard of Sertaconazole (nitrate). This product is intended for research and analytical applications. Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells.
    Sertaconazole nitrate (Standard)
  • HY-143334
    Antifungal agent 84
    		Inhibitor
    Antibacterial agent 84 is an antifungal compound. Antibacterial agent 84 inhibits candidiasis in a CNB1-dependent way. Antibacterial agent 84 inhibits the C. albicans biofilm's viability.
    Antifungal agent 84
  • HY-N11434
    Anisocoumarin H
    		Inhibitor
    Anisocoumarin H is a coumarin that exhibits antifungal activity. Anisocoumarin H shows the activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs of 62.5 µg/mL.
    Anisocoumarin H
  • HY-132925
    Antifungal agent 16
    		Inhibitor
    Antifungal agent 16 displays considerable antibacterial activity and superior antifungal activity with reference to ciprofloxacin and fluconazole, respectively.
    Antifungal agent 16
  • HY-101401R
    3-(Methylthio)propionic acid (Standard)
    		Inhibitor
    3-(Methylthio)propionic acid (Standard) is the analytical standard of 3-(Methylthio)propionic acid. This product is intended for research and analytical applications. 3-(Methylthio)propionic acid is an intermediate in the methionine metabolism.
    3-(Methylthio)propionic acid (Standard)
  • HY-147944
    Antimicrobial agent-4
    		Inhibitor
    Antimicrobial agent-4 (compound 6a) is a potent antimicrobial agent. Antimicrobial agent-4 exhibits considerable activity against the microbial pathogens. Antimicrobial agent-4 delivers reliable toxicity to kill the bacteria and fungi. Antimicrobial agent-4 shows high binding energy value of −10.0 kcal/mole against the target enzyme.
    Antimicrobial agent-4
  • HY-N12591
    Iso-isariin B
    		Inhibitor
    Iso-isariin B is an analogue of cyclocarboxyphenate, which can be used in antifungal studies.
    Iso-isariin B
Cat. No. Product Name / Synonyms Application Reactivity