2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P3156
    Syringomycin E
    		Inhibitor
    Syringomycin E is an antifungal cyclic lipodepsinonapeptide. Syringomycin E exhibits growth inhibition of Saccharomyces cerevisiae through interaction with the plasma membrane. Syringomycin E causes K+ efflux, Ca2+ influx, and changes in membrane potential, and is related to channel formation.
    Syringomycin E
  • HY-131134S
    Fosetyl-aluminum-d15
    		Inhibitor
    Fosetyl-aluminum-d15 (Fosetyl-Al-d15) is the deuterium labeled Fosetyl-aluminum. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops.
    Fosetyl-aluminum-d<sub>15</sub>
  • HY-132912
    Antifungal agent 15
    		Inhibitor
    Antifungal agent 15 has the most potent activity with EC50 values of 0.52 and 0.50 μg/mL against S. sclerotiorum and B. cinerea, respectively.
    Antifungal agent 15
  • HY-133951
    4',6,7-Trimethoxyisoflavone
    		Inhibitor
    4',6,7-Trimethoxyisoflavone is an isoflavone with antimicrobial activities against a wide range of bacteria and fungi. 4',6,7-Trimethoxyisoflavone also has antioxidant effects.
    4',6,7-Trimethoxyisoflavone
  • HY-120432
    CaMdr1p-IN-1
    		Inhibitor
    CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candida albicans with MIC of 10 μM.
    CaMdr1p-IN-1
  • HY-N2563
    Neocnidilide
    		Inhibitor
    Neocnidilide is an alkylphthalide, which has the activity of inhibiting the growth of mycotoxin-producing fungi. Neocnidilide also has larvicidal activity against D. melanogaster with a LC50 value of 9.9 μmol/mL.
    Neocnidilide
  • HY-126724R
    Flutianil (Standard)
    		Inhibitor
    Flutianil (Standard) is the analytical standard of Flutianil. This product is intended for research and analytical applications. Flutianil is a fungicide, which specifically inhibits the powdery mildew species. Flutianil inhibits the haustorium formation and subsequent mycelia growth.
    Flutianil (Standard)
  • HY-119759AR
    Lipoxamycin hemisulfate (Standard)
    		Inhibitor
    Lipoxamycin (hemisulfate) (Standard) is the analytical standard of Lipoxamycin (hemisulfate). This product is intended for research and analytical applications. Lipoxamycin hemisulfate is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM[1][2].
    Lipoxamycin hemisulfate (Standard)
  • HY-N1650
    Pygenic acid B
    		Inhibitor
    Pygenic acid B is a triterpenoid that can be isolated from the leaves of Glochidion obliquum. Pygenic acid B shows antifungal activity against C. musae. Pygenic acid B shows ONOO- scavenging activity.
    Pygenic acid B
  • HY-162488
    Laccase-IN-3
    		Inhibitor
    Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS.
    Laccase-IN-3
  • HY-136961
    NK 1971
    		Inhibitor
    NK 1971 (NK266 orotate) is a derivative of NK266 and shows potential antifungal activity. NK 1971 may result in decreased motor skills and seizures in animals.
    NK 1971
  • HY-N2646
    5-Heptadec-cis-8-enylresorcinol
    		Inhibitor
    5-Heptadec-cis-8-enylresorcinol is a 5-alkylresorcinol that can be isolated from etiolated rice seedlings. 5-Heptadec-cis-8-enylresorcinol is an antifungal agent against the rice blast fungus. 5-Heptadec-cis-8-enylresorcinol mediates DNA relaxation.
    5-Heptadec-cis-8-enylresorcinol
  • HY-108280
    Tropesin
    		Inhibitor
    Tropesin (VUFB 12018; Repanidal) is a nonsteroid antiinflammatory agent (NSAIA) that inhibits the growth of Trichoderma viride.
    Tropesin
  • HY-139676
    RMG8-8
    		Inhibitor
    RMG8-8 shows the excellent efficacy against C. neoformans (1.56 μg/mL).
    RMG8-8
  • HY-116290A
    Zaragozic acid A trisodium
    Zaragozic acid A trisodium is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase.
    Zaragozic acid A trisodium
  • HY-N9710
    Bis(methylthio)gliotoxin
    Bis(methylthio)gliotoxin is a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis.
    Bis(methylthio)gliotoxin
  • HY-12772R
    Hydroxy Itraconazole (Standard)
    		Inhibitor
    Levetiracetam (Standard) is the analytical standard of Levetiracetam. This product is intended for research and analytical applications. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent.
    Hydroxy Itraconazole (Standard)
  • HY-136153
    Amphotericin X1
    		Inhibitor
    Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively.
    Amphotericin X1
  • HY-N10057
    5-epi-Jinkoheremol
    		Inhibitor
    5-epi-Jinkoheremol exhibits more potent fungicidal activity than validamycin.
    5-epi-Jinkoheremol
  • HY-N1453R
    Hypocrellin B (Standard)
    		Inhibitor
    Hypocrellin B (Standard) is the analytical standard of Hypocrellin B. This product is intended for research and analytical applications. Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities[1][2][3].
    Hypocrellin B (Standard)
Cat. No. Product Name / Synonyms Application Reactivity