2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-147970
    Antifungal agent 34
    		Inhibitor
    Antifungal agent 34 (compound 6i) is a potent antifungal agent. Antifungal agent 34 shows a potent antifungal activity against Candida albicans, with a MIC of 4 µg/mL. Antifungal agent 34 shows significant inhibition on Candida albicans hyphae and biofilm development. Antifungal agent 34 exhibits no cytotoxicity to mammalian cells.
    Antifungal agent 34
  • HY-B0849S
    Azoxystrobin-d4
    		Inhibitor
    Azoxystrobin-d4 is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.
    Azoxystrobin-d<sub>4</sub>
  • HY-151422
    Chitin synthase inhibitor 12
    Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs).
    Chitin synthase inhibitor 12
  • HY-122200
    Phenamacril
    		Inhibitor
    Phenamacril (JS399-19) inhibits activity of myosin I non-competitively with an IC50 of 360 nM through suppression of the ATPase activity, exhibits therefore an antifungal efficacy towards Fusarium species.
    Phenamacril
  • HY-B0896R
    Triacetin (Standard)
    		Inhibitor
    Triacetin (Standard) is the analytical standard of Triacetin. This product is intended for research and analytical applications. Triacetin is a synthetic compound that is a triester of glycerol and acetic acid.
    Triacetin (Standard)
  • HY-N11741
    Trichodermin
    		Inhibitor
    Trichodermin, a naturally occurring sesquiterpene antibiotic, is a potent protein synthesis inhibitor. Trichodermin binds to the eukaryotic ribosome to inhibit the translation of proteins by means of interaction with the peptidyl transferase. Trichodermin inhibits oral cancer growth by inducing apoptotic mitochondrial dysfunction and HDAC-2-mediated signaling. Trichodermin exhibits potent antimicrobial activity against filamentous fungi and yeasts and bacteria.
    Trichodermin
  • HY-149585
    Chitin synthase inhibitor 14
    		Inhibitor
    Chitin synthase inhibitor 14 (compound 4n) is chitin synthase (CHS) inhibitor. Chitin synthase inhibitor 14 has antifungal activity while possessed the potency against drug-resistant fungal variants.
    Chitin synthase inhibitor 14
  • HY-143335
    Antifungal agent 52
    		Inhibitor
    Antifungal agent 52 (compound 6c) is a tetrazole derivative. Antifungal agent 52 inhibits the synthesis of Ergosterol (HY-N0181). Antifungal agent 52 exhibit a significant antifungal activity against Candida albicans. Antifungal agent 52 affects C. albicans sessile cell membrane permeabilization.
    Antifungal agent 52
  • HY-123230S
    Trifloxystrobin-d6
    		Inhibitor
    Trifloxystrobin-d6 is the deuterium labeled Trifloxystrobin. Trifloxystrobin (CGA 279202) is a fungicide, with EC50s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h.
    Trifloxystrobin-d<sub>6</sub>
  • HY-162458
    Antifungal agent 100
    		Inhibitor
    Antifungal agent 100 (compound 3i) exhibits significant antifungal effects against S. sclerotiorum with an EC50 value of 0.33 mg/L. Antifungal agent 100 displays an IC50 of 0.63 mg/mL against the Succinate dehydrogenase (SDH) of S. sclerotiorum.
    Antifungal agent 100
  • HY-N8935
    Eucamalduside A
    Eucamalduside A can be isolated from the leaves of Eucalyptus camaldulensis. Eucalyptus camaldulensis has antibacterial and antifungal activity.
    Eucamalduside A
  • HY-B0101S1
    Fluconazole-13C2,15N
    		Inhibitor
    Fluconazole-13C2,15N (UK-49858-13C2,15N) is the 13C and 15N labeled isotope of Fluconazole (HY-B0101). Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL.
    Fluconazole-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N
  • HY-167879
    (Rac)-NPD6433
    		Inhibitor
    (Rac)-NPD6433 is a racemate of NPD6433. NPD6433 is a triazenyl indole with broad-spectrum activity against all screening fungal strains. NPD6433 targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH-oxidation activity and arresting essential fatty acid biosynthesis.
    (Rac)-NPD6433
  • HY-123025
    Schizozygine
    		Inhibitor
    Schizozygine is an alkaloid that can be isolated from Schizozygia caffaeoides. Schizozygia caffaeoides has been used as a traditional medicine for skin disease. The leaf extracts has high antifungal and antimicrobial activity.
    Schizozygine
  • HY-16561S1
    Resveratrol-13C6
    		Inhibitor
    Resveratrol-13C6 is the 13C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
    Resveratrol-<sup>13</sup>C<sub>6</sub>
  • HY-P3156
    Syringomycin E
    		Inhibitor
    Syringomycin E is an antifungal cyclic lipodepsinonapeptide. Syringomycin E exhibits growth inhibition of Saccharomyces cerevisiae through interaction with the plasma membrane. Syringomycin E causes K+ efflux, Ca2+ influx, and changes in membrane potential, and is related to channel formation.
    Syringomycin E
  • HY-131134S
    Fosetyl-aluminum-d15
    		Inhibitor
    Fosetyl-aluminum-d15 (Fosetyl-Al-d15) is the deuterium labeled Fosetyl-aluminum. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops.
    Fosetyl-aluminum-d<sub>15</sub>
  • HY-132912
    Antifungal agent 15
    		Inhibitor
    Antifungal agent 15 has the most potent activity with EC50 values of 0.52 and 0.50 μg/mL against S. sclerotiorum and B. cinerea, respectively.
    Antifungal agent 15
  • HY-133951
    4',6,7-Trimethoxyisoflavone
    		Inhibitor
    4',6,7-Trimethoxyisoflavone is an isoflavone with antimicrobial activities against a wide range of bacteria and fungi. 4',6,7-Trimethoxyisoflavone also has antioxidant effects.
    4',6,7-Trimethoxyisoflavone
  • HY-120432
    CaMdr1p-IN-1
    		Inhibitor
    CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candida albicans with MIC of 10 μM.
    CaMdr1p-IN-1
Cat. No. Product Name / Synonyms Application Reactivity