2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-162784
    CYP51-IN-19
    		Inhibitor
    CYP51-IN-19 (compound C07) is a potent CYP51 inhibitor. CYP51-IN-19 stimulates reactive oxygen species (ROS) and exhibits potent fungicidal activity.
    CYP51-IN-19
  • HY-19965
    UK-2A
    		Inhibitor
    UK-2A (Antibiotic UK 2A) is a potent antifungal antibiotic. UK-2A shows antifungal activity.
    UK-2A
  • HY-146747
    Antifungal agent 26
    		Inhibitor
    Antifungal agent 26, a Pradimicin A derivative, shows antifungal, antiviral, and antiparasitic activities through binding to d-mannose (Man)-containing glycans of pathogenic species.
    Antifungal agent 26
  • HY-168042
    Antibacterial agent 243
    		Inhibitor
    Antibacterial agent 243 is an antibacterial agent, with EC50 values of 0.64 mg/L for Valsa mali, 26 mg/L for allicin, and 0.33 mg/L for tebuconazole. Antibacterial agent 243 can induce hyphal shrinkage and collapse, trigger the accumulation of reactive oxygen species inside cells, regulate antioxidant enzyme activity, initiate lipid peroxidation, and ultimately cause irreversible oxidative damage to Valsa mali cells.
    Antibacterial agent 243
  • HY-162256
    Antibacterial agent 184
    		Inhibitor
    Antibacterial agent 184 (compound 4j) is a fungal inhibitor that is toxic to the plant pathogenic fungus Sclerotinia sclerotiorum. Antibacterial agent 184 can effectively inhibit Sclerotinia sclerotiorum (IR>97%).
    Antibacterial agent 184
  • HY-126117
    (+)-Xylariamide A
    		Inhibitor
    (+)-Xylariamide A (compound 6b) is a mycobacterial and fungal carbonic anhydrase probe with inhibitory activity against pathogen β-carbonic anhydrases.
    (+)-Xylariamide A
  • HY-120921
    Zoxamide
    Zoxamide (RH-7281) is an oomycete fungicide. Zoxamide arrests nuclear division in Phytophthora capsici germlings and destroyed the microtubule cytoskeleton.
    Zoxamide
  • HY-153624
    Antifungal agent 59
    		Inhibitor
    Antifungal agent 59 is an antifungal agent, with MIC values of 0.01-1 μg/mL. Antifungal agent 59 prevents the formation of fungi biofilms, but also has safety.
    Antifungal agent 59
  • HY-162271
    Antibacterial agent 187
    		Inhibitor
    Antibacterial agent 187 (IKE7) is a derivative containing imidazole and triazolacridone structures that target yeast topoisomerase II. Antibacterial agent 187 has antifungal activity and MIC value of resistance to fluconazole (HY-B0101) is 32-64 μg/mL.
    Antibacterial agent 187
  • HY-N10307
    Anserinone B
    		Inhibitor
    Anserinone B is an antifungal and antibacterial benzoquinone. Anserinone B causes radial growth reductions of 50% and 37% against S.fimicola and A. furfuraceus, respectively. Anserinones B also displays moderate cytotoxicity in the NCI’s 60 human tumor cell line panel (GI50=4.4 µg/mL).
    Anserinone B
  • HY-N8745
    α-Peltatin
    		Inhibitor
    α-Peltatin is an aryl lignan. α-Peltatin has anticancer and antifungal activity. α-Peltatin inhibits DNA topoisomerase and tubulin polymerization .
    α-Peltatin
  • HY-114518
    Butenafine
    		Inhibitor
    Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent. Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as  tinea pedis,  tinea cruris, tinea versicolor.
    Butenafine
  • HY-176210
    CYP51-IN-24
    CYP51-IN-24 (Compound 22) is a Sterol 14α-Demethylase (CYP51) inhibitor. CYP51-IN-24 exhibits potent inhibitory activity against wild-type and drug-resistant fungi. CYP51-IN-24 inhibits ergosterol biosynthesis by binding to the fungal CYP51 enzyme. CYP51-IN-24 can be used in research and drug development against drug-resistant fungal infections.
    CYP51-IN-24
  • HY-117313
    Fumitremorgin B
    		Inhibitor
    Fumitremorgin B is a tremorgenic mycotoxin. Fumitremorgin B exhibits significant antifungal activities, with MICs of 6.25-50 μg/mL.
    Fumitremorgin B
  • HY-P2365
    Histatin-8
    		Inhibitor
    Histatin-8 is a part of the Histatin-3 central sequence and is known as hemagglutination-inhibiting peptide. Histatin-8 is a potent anti-fungal peptide. Histatin-8 shows antimicrobial activity against yeast strains. Histatin-8 can be used for oral thrush research.
    Histatin-8
  • HY-N9768
    (10E,12E)-9-Oxo-10,12-octadecadienoic acid
    		Inhibitor
    (10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist that can be isolated from the basidiomycete Gomphus floccosus. (10E,12E)-9-Oxo-10,12-octadecadienoic acid enhances fatty acid oxidation through PPARα activation, thereby inhibiting triglyceride accumulation. (10E,12E)-9-Oxo-10,12-octadecadienoic acid also has antifungal (Fungal) activity.
    (10E,12E)-9-Oxo-10,12-octadecadienoic acid
  • HY-W089856R
    Chlorobutanol hemihydrate (Standard)
    		Inhibitor
    Chlorobutanol (hemihydrate) (Standard) is the analytical standard of Chlorobutanol (hemihydrate). This product is intended for research and analytical applications. Chlorobutanol hemihydrate is a pharmaceutical preservative. Chlorobutanol hemihydrate is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol hemihydrate is widely used in food and cosmetic industry.
    Chlorobutanol hemihydrate (Standard)
  • HY-B2056
    Triforine
    		Inhibitor
    Triforine (CELA W 524), a systemic fungicide, was shown to display a moderate to distinct fungitoxic activity in vitro towards several pathogenic and non-pathogenic fungi.
    Triforine
  • HY-146107
    Antitubercular agent-23
    		Inhibitor
    Antitubercular agent-23 (Compound 3a) is a potent anticandidiasis and antitubercular agent with MIC values of 1.1 µg/ml and 1 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively.
    Antitubercular agent-23
  • HY-122451
    Ofurace
    		Inhibitor
    Ofurace is a fungicide that is extremely active against Pythium ultima, Phytophthora tabacum and Phytophthora palmi. Ofurace has a greater effect on sporangia formation than on mycelium growth.
    Ofurace
Cat. No. Product Name / Synonyms Application Reactivity