2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118448R
    2,4-Diacetylphloroglucinol (Standard)
    2,4-Diacetylphloroglucinol (Standard) is the analytical standard of 2,4-Diacetylphloroglucinol (HY-118448). This product is intended for research and analytical applications. 2,4-Diacetylphloroglucinol is a polyketide antibiotic produced by Pseudomonas fluorescens. 2,4-Diacetylphloroglucinol exhibits broad-spectrum toxicity against various organisms such as bacteria, fungi, oomycetes, and nematodes. 2,4-Diacetylphloroglucinol can also inhibit plant pathogens and affect the root development of tomato seedlings.
    2,4-Diacetylphloroglucinol (Standard)
  • HY-122955
    Xanthobaccin A
    		Inhibitor
    Xanthobaccin A is an antifungal compound, can be isolated from the culture fluid of Stenotrophomonas sp. strain SB-K88. Xanthobaccin A has potent inhibitory effect on sugar beet damping-off disease.
    Xanthobaccin A
  • HY-P5601
    Thanatin
    		Inhibitor
    Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption.
    Thanatin
  • HY-N12513R
    Cyclo(L-Phe-trans-4-OH-L-Pro) (Standard)
    		Inhibitor
    5α-Cholestan-3β-ol (Standard) is the analytical standard of 5α-Cholestan-3β-ol. This product is intended for research and analytical applications. 5α-Cholestan-3β-ol is a derivitized steroid compound.
    Cyclo(L-Phe-trans-4-OH-L-Pro) (Standard)
  • HY-N7123S
    Sulfacetamide-d4
    		Inhibitor
    Sulfacetamide-d4 (Sulphacetamide-d4) is the deuterium labeled Sulfacetamide (HY-N7123). Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide has antifungal and antibacterial activities.
    Sulfacetamide-d<sub>4</sub>
  • HY-132933
    Fungicide4
    		Inhibitor
    Fungicide4 shows the high activity against the P. infestans strain.
    Fungicide4
  • HY-121117
    Chloracetophos
    		Inhibitor
    Derivatives of lucanthone and hycanthone may be mutagenic to germ cells of Drosophila at different stages.
    Chloracetophos
  • HY-B0370S
    Tolnaftate-d7
    		Inhibitor
    Tolnaftate-d7 is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent.
    Tolnaftate-d<sub>7</sub>
  • HY-129580
    Nannochelin B
    		Inhibitor
    Nannochelin B is a novel citrate-hydroxamate siderophore with a growth-inhibitory activity against some bacteria and fungi.
    Nannochelin B
  • HY-121431
    FR-901235
    FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. FR-901235 partially restored the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice.
    FR-901235
  • HY-143405
    Antifungal agent 24
    		Inhibitor
    Antifungal agent 24 (Compound 6) is an antifungal agent against Candida albicans with a MIC value of 0.03 μg/mL.
    Antifungal agent 24
  • HY-146062
    Antibacterial agent 101
    		Inhibitor
    Antibacterial agent 101 (Compd 7f) is an antimicrobial (antibacterial and antifungal) agent, with MIC values between 4 and 32 µg/mL.
    Antibacterial agent 101
  • HY-N10215
    Canadensolide
    		Inhibitor
    Canadensolide is an antifungal metabolite of Penicillium canadense.
    Canadensolide
  • HY-B1790S
    Terconazole-d4
    		Inhibitor 99.0%
    Terconazole-d4 is the deuterium labeled Terconazole. Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.
    Terconazole-d<sub>4</sub>
  • HY-N2071R
    Cedrol (Standard)
    		Inhibitor
    Cedrol (Standard) is the analytical standard of Cedrol. This product is intended for research and analytical applications. Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties.
    Cedrol (Standard)
  • HY-171541
    CDA-IN-1
    		Inhibitor
    CDA-IN-1 (Compound vs#2-1) is an inhibitor of chitin deacetylase (CDA). CDA-IN-1 exhibits antifungal activity. It can inhibit fungal growth by suppressing the activity of fungal CDA, activating the plant immune response, and accumulating reactive oxygen species (ROS). At a concentration of 100 μM, CDA-IN-1 can achieve inhibition rates of 86.9% and 74.5% against PxCDA1 and PxCDA2 of P. xanthii, respectively. CDA-IN-1 can be applied to the research in the field of controlling plant fungal diseases, such as the research on diseases like cucurbit powdery mildew and tomato gray mold .
    CDA-IN-1
  • HY-10882S1
    Clotrimazole-d10
    		Inhibitor
    Clotrimazole-d10 is deuterated labeled Clotrimazole (HY-10882). Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.
    Clotrimazole-d<sub>10</sub>
  • HY-N2573A
    Corydalmine hydrochloride
    		Inhibitor
    Corydalmine hydrochloride inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine hydrochloride acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine hydrochloride alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.
    Corydalmine hydrochloride
  • HY-N8336
    IT-143A
    		Inhibitor
    IT-143A is an antibiotic, that exhibits antibacterial and antifungal activity against Micrococcus luteus and Aspergillus fumigatus with MIC of 6.25-25 μg/mL. IT-143A inhibits growth of cancer cell KB with an IC50 of 0.36 ng/mL.
    IT-143A
  • HY-N10273
    Deoxyfusapyrone
    Deoxyfusapyrone is an antifungal alpha-pyrone from Fusarium semitectum. Deoxyfusapyrone shows a strong antibiotic activity towards Geotrichum candidum in disk diffusion assays, but is not toxic to Artemia salina larvae.
    Deoxyfusapyrone
Cat. No. Product Name / Synonyms Application Reactivity