2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-117235R
    Diallyl Trisulfide (Standard)
    		Inhibitor
    Diallyl Trisulfide (Standard) is the analytical standard of Diallyl Trisulfide. This product is intended for research and analytical applications. Diallyl Trisulfide is an orally active anticancer agent that can be isolated from garlic. Diallyl Trisulfide has the ability to induce apoptosis and exhibits anticancer, anti-inflammatory, antioxidant, and antibacterial activities. Diallyl Trisulfide can be used to study a variety of cancers, including liver, colon and prostate cancer[1][2][3][4].
    Diallyl Trisulfide (Standard)
  • HY-12772S1
    (2R,4S)-Hydroxy Itraconazole-d8
    (2R,4S)-Hydroxy Itraconazole-d8 is the deuterium labeled (2R,4S)-Hydroxy Itraconazole[1].
    (2R,4S)-Hydroxy Itraconazole-d<sub>8</sub>
  • HY-B1134AS
    Imazalil-d5 sulfate
    Imazalil-d5 (sulfate) is the deuterium labeled Imazalil sulfate.
    Imazalil-d<sub>5</sub> sulfate
  • HY-17395AS
    Terbinafine-d7
    		Inhibitor
    Terbinafine-d7 is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM. Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria.
    Terbinafine-d<sub>7</sub>
  • HY-12772S2
    (2R,4S)-Hydroxy Itraconazole-d5
    		99.40%
    (2R,4S)-Hydroxy Itraconazole-d5 is the deuterium labeled (2R,4S)-Hydroxy Itraconazole.
    (2R,4S)-Hydroxy Itraconazole-d<sub>5</sub>
  • HY-B0454S1
    Miconazole-d5 nitrate
    		Inhibitor
    Miconazole-d5 (nitrate) is the deuterium labeled Miconazole. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects.
    Miconazole-d<sub>5</sub> nitrate
  • HY-W725543
    Chlorphenesin-d5
    Chlorphenesin-d5 is the deuterium labeled Chlorphenesin (HY-A0133). Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics.
    Chlorphenesin-d<sub>5</sub>
  • HY-151420
    Chitin synthase inhibitor 10
    		Inhibitor
    Chitin synthase inhibitor 10 is a chitin synthase inhibitor. Chitin synthase inhibitor 10 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs).
    Chitin synthase inhibitor 10
  • HY-D0226R
    Quinizarin (Standard)
    		Inhibitor
    Quinizarin (Standard) is the analytical standard of Quinizarin. This product is intended for research and analytical applications. Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth.
    Quinizarin (Standard)
  • HY-154996
    Gamma-Glutamyl Transferase-IN-2
    		Inhibitor
    Gamma-Glutamyl Transferase-IN-2 (compound 4dq) is a β-carboline 1-hydrazide inhibitor with antifungal and antibacterial activities, targeting to glutamyltransferase. Gamma-Glutamyl Transferase-IN-2 acts function by resulting the accumulation of reactive oxygen species, destruction of cell membranes, and dysregulation of histone acetylation.
    Gamma-Glutamyl Transferase-IN-2
  • HY-N10101
    Eriobofuran
    		Inhibitor
    Eriobofuran is an antifungal agent can be isolated from Sorbus aucuparia.
    Eriobofuran
  • HY-155700
    SDH-IN-6
    		Inhibitor
    SDH-IN-6 (compound 6i) is a potent succinate dehydrogenase (SDH) inhibitor. SDH-IN-6 has antifungal activity against Valsa mali with an EC50 value of 1.77 mg/L.
    SDH-IN-6
  • HY-156252
    Antifungal agent 75
    		Inhibitor
    Antifungal agent 75 (compound 6r) is a potent antifungal agent against Candida albicans. Antifungal agent 75 significantly inhibits the formation of C. albicans biofilm, increases the permeability of the cell membrane, reduces the ergosterol level of the cell membrane, damages the membrane structure, and destroys the integrity of the cell structure to exert excellent antifungal activity.
    Antifungal agent 75
  • HY-169202
    Antifungal agent 118
    		Inhibitor
    Antifungal agent 118 (compund C22) inhibits the hyphal growth of V. mali by inducing oxidative damage and disrupting the integrity of the cell membrane.
    Antifungal agent 118
  • HY-149653
    SDH-IN-10
    		Inhibitor
    SDH-IN-10 is a potent succinate dehydrogenase inhibitor (SDHI) with antifungal effects.
    SDH-IN-10
  • HY-125666
    Agistatin B
    Agistatin B, isolated from fungus, is a mycotoxin. Agistatin B inhibits cholesterol synthesis.
    Agistatin B
  • HY-N10293
    Monaschromone
    		Inhibitor
    Monaschromone, a polyketide metabolite, significantly inhibits the growth of B. cinerea, A. solani, M. oryzae, and G. saubinettii, with the MIC values ranging from 6.25 to 12.5 μM.
    Monaschromone
  • HY-129208
    Viridicatumtoxin
    		Inhibitor
    Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a LD50 of 122.4 mg/kg in rats.
    Viridicatumtoxin
  • HY-146427
    Antifungal agent 29
    		Inhibitor
    Antifungal agent 29 (compound 9d) is a potent, selective and non-toxic antifungal agent. Antifungal agent 29 shows antifungal activity towards Cryptococcus neoformans (MIC ≤ 0.23 μM).
    Antifungal agent 29
  • HY-145348
    MK-5204
    		Inhibitor
    MK-5204 is an orally active β-1,3-glucan synthesis inhibitor.
    MK-5204
Cat. No. Product Name / Synonyms Application Reactivity