2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-124952
    iKIX1
    		Inhibitor 99.76%
    iKIX1 is an antifungal agent and resensitizes drug-resistant C. glabrata to azole antifungals in vitro. iKIX1 inhibits the interaction between the KIX domain of the mediator subunit CgGal11A and the activation domain of CgPdr1, the IC50 and Ki values are 190.2 μM and 18 μM, respectively. iKIX1 is used for the study of multidrug resistance and C. glabrata infection.
    iKIX1
  • HY-N7364R
    (E)-β-Farnesene (Standard)
    		Inhibitor
    (E)-β-Farnesene (Standard) is the analytical standard of (E)-β-Farnesene. This product is intended for research and analytical applications. (E)-β-Farnesene (trans-β-Farnesene) is a volatile sesquiterpene hydrocarbon which can be found in Phlomis aurea Decne essential oil. (E)-β-Farnesene can be used as a feeding stimulant for the sand fly Lutzomyia longipalpis.
    (E)-β-Farnesene (Standard)
  • HY-15660S
    Efinaconazole-d4
    		Inhibitor 99.91%
    Efinaconazole-d4 is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species.
    Efinaconazole-d<sub>4</sub>
  • HY-116541
    Acibenzolar-S-methyl
    		Inhibitor 99.77%
    Acibenzolar-S-methyl (ASM) is a plant resistance inducer that mimics pathogen-host interactions and leads to systemic acquired resistance in plants. Acibenzolar-S-methyl helps reduce the use of pesticides and can be used in research to prevent plant diseases.
    Acibenzolar-S-methyl
  • HY-153410
    Antifungal agent 49
    		Inhibitor
    Antifungal agent 49 (Example 112) is an antifungal agent. Antifungal agent 49 is active against Cryptococcus neoformans with a MIC value of 49 μM.
    Antifungal agent 49
  • HY-146145
    Metyltetraprole
    		Inhibitor 99.53%
    Metyltetraprole is a promising fungicide with EC50 values of both 0.002 ppm against sensitive wild-type and G143A mutant of Zymoseptoria tritici. Metyltetraprole is effective against QoI (quinone outside inhibitor) resistant strains. Metyltetraprole inhibits the respiratory chain via complex III.
    Metyltetraprole
  • HY-149876
    SDH-IN-5
    		Inhibitor 99.86%
    SDH-IN-5 (compound 7d) is a potent succinate dehydrogenase (SDH) inhibitor, with an IC50 of 3.293 μM. SDH-IN-5 is also exhibits antifungal activity, with an EC50 of 0.046 μg/mL against R. solani. SDH-IN-5 could significantly inhibit the growth of R. solani in rice leaves with excellent protective and curative efficacies.
    SDH-IN-5
  • HY-N6643
    Rubropunctamine
    		Inhibitor
    Rubropunctamine is a redMonascus pigment. Not only Rubropunctamine exerts antibiotic action against bacteria but also against some yeast and filamentous fungi strains. Rubropunctamine has potential embryotoxicity and teratogenicity.
    Rubropunctamine
  • HY-106784A
    (E)-Ajoene
    		Inhibitor
    (E)-Ajoene is a oxygenated ajoene and organosulfur compound, which can be acquired via allicin decomposing. The polysulfides from garlic can be converted by human red blood cells into hydrogen sulfide (H2S) and allyl glutathione. (E)-Ajoene has been proved to show neuroprotective effects against ischemic damage. (E)-Ajoene is orally active to inhibit lipid peroxidation. (E)-Ajoene increases the number of cresyl violet-positive neurons and decreases the number of reactive gliosis in the CA1 region.
    (E)-Ajoene
  • HY-126200
    Fenpropidin
    		Inhibitor 99.48%
    Fenpropidin, a piperidine, is a fungicide used to control a range of diseases in cereals. Fenpropidin shows antifungal activity against different human pathogenic yeasts and filamentous fungi.
    Fenpropidin
  • HY-B1878R
    Faltan (Standard)
    		Inhibitor 98.69%
    Faltan (Standard) is the analytical standard of Faltan. This product is intended for research and analytical applications. Faltan is a dicarboximide fungicide, widely used on vines and several vegetable crops, and is also cytotoxic effect on human bronchial epithelial cells.
    Faltan (Standard)
  • HY-B0850R
    Difenoconazole (Standard)
    		Inhibitor
    Difenoconazole (Standard) is the analytical standard of Difenoconazole. This product is intended for research and analytical applications. Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth.
    Difenoconazole (Standard)
  • HY-W010201R
    Citronellol (Standard)
    		Inhibitor
    Citronellol (Standard) is the analytical standard of Citronellol. Citronellol (Standard) is an orally active inducer of apoptosis. Citronellol (Standard) can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol (Standard) can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol (Standard) can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol (Standard) exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis.
    Citronellol (Standard)
  • HY-148160A
    Diamthazole hydrochloride
    		Inhibitor 99.86%
    Diamthazole (Dimazole) hydrochloride is an antifungal agent. Diamthazole hydrochloride can be used for the research of infection.
    Diamthazole hydrochloride
  • HY-W004643
    Akardite II
    		Inhibitor
    Akardite II (AK-II) is a stabilizer for nitrocellulose (NC) propellants as it scavenges NOx. Akardite II helps control a variety of plant pathogens and weeds, which can be used as fungicides and herbicides.
    Akardite II
  • HY-N7684
    Picropodophyllone
    		Inhibitor 99.89%
    Picropodophyllone, an aryltetralin lignan, is isolated from leaves of Podophyllum hexandrum, and has antifungal activities.
    Picropodophyllone
  • HY-B1729R
    Phenoxyethanol (Standard)
    		Inhibitor
    Phenoxyethanol (Standard) is the analytical standard of Phenoxyethanol. This product is intended for research and analytical applications. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al.
    Phenoxyethanol (Standard)
  • HY-U00097
    L-4-Oxalysine hydrochloride
    		Inhibitor 99.95%
    L-4-Oxalysine hydrochloride is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China which has shown antitumor activities.
    L-4-Oxalysine hydrochloride
  • HY-102025
    Antifungal agent 1
    		Inhibitor ≥98.0%
    Antifungal agent 1 is a potent antifungal agent.
    Antifungal agent 1
  • HY-W749242
    Paclobutrazol-d4
    		Inhibitor
    Paclobutrazol-d4 is the deuterium labeled Paclobutrazol. Paclobutrazol is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins.
    Paclobutrazol-d<sub>4</sub>
Cat. No. Product Name / Synonyms Application Reactivity