2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0570S
    Hydroxytyrosol-d4
    		Inhibitor
    Hydroxytyrosol-d4 is the deuterium labeled Hydroxytyrosol. Hydroxytyrosol (DOPET) is a phenolic compound drawn from the olive tree and its leaves with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects.
    Hydroxytyrosol-d<sub>4</sub>
  • HY-Y1825
    Benzimidazole
    		Inhibitor 99.94%
    Benzimidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Benzimidazole
  • HY-B2008
    Famoxadone
    		Inhibitor 99.86%
    Famoxadone (DPX-JE874) is a fungicide acting against a broad spectrum of fungi and is widely used in Integrated Pest Management strategies in different agricultural crops.
    Famoxadone
  • HY-E70119
    Pectate Lyase
    Pectate Lyase is an important enzyme secreted by plant pathogens. Pectate Lyase plays a critical role in pectin degradation and fungal virulence. Pectate Lyase induces plant immune responses and contributes to virulence.
    Pectate Lyase
  • HY-B0934R
    Ethylparaben (Standard)
    		Inhibitor
    Ethylparaben (Standard) is the analytical standard of Ethylparaben. This product is intended for research and analytical applications. Ethylparaben is the ethyl ester of paraben and is used as an antifungal preservative and food additive.
    Ethylparaben (Standard)
  • HY-N0414R
    Trigonelline (Standard)
    		Inhibitor
    Trigonelline (Standard) is the analytical standard of Trigonelline. This product is intended for research and analytical applications. Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.
    Trigonelline (Standard)
  • HY-130802
    5-Aminouridine
    		Inhibitor 99.31%
    5-Aminouridine can modify nucleobases and can be incorporated into the target DNA. 5-Aminouridine exhibits a wide range of biological activity and it inhibits the growth of tumors, fungi and viruses.
    5-Aminouridine
  • HY-N7701A
    L-Triguluronic acid
    		≥98.0%
    L-Triguluronic acid is a linear polysaccharide copolymer composed of three L-guluronic acid (G) and can be used to from Alginate. Alginate is a generic name of unbranched polyanionic polysaccharides and can be used for the research of anti-fungal agents delivery carries.
    L-Triguluronic acid
  • HY-122950
    Harzianic acid
    		Inhibitor
    Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide.
    Harzianic acid
  • HY-B0370R
    Tolnaftate (Standard)
    		Inhibitor
    Tolnaftate (Standard) is the analytical standard of Tolnaftate. This product is intended for research and analytical applications. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. .
    Tolnaftate (Standard)
  • HY-126237
    Acetyllovastatin
    		Inhibitor 98.86%
    Acetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against the enzyme acetylcholinesterase with an IC50 of 79 μg/mL. Lovastatin has been found to display antifungal activity, and suppresses proliferation of a number of transformed cell lines.
    Acetyllovastatin
  • HY-15141R
    Staurosporine (Standard)
    		Inhibitor
    Staurosporine (Standard) is the analytical standard of Staurosporine. This product is intended for research and analytical applications. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer[1][2][3][4][5].
    Staurosporine (Standard)
  • HY-N8173
    Valtrate hydrine B4
    		Inhibitor
    Valtrate hydrine B4 is a natural compound with antifungal activities.
    Valtrate hydrine B4
  • HY-N4302
    Monensin
    		Inhibitor
    Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects.
    Monensin
  • HY-N3056
    Pinosylvin monomethyl ether
    		≥99.0%
    Pinosylvin monomethyl ether has antibacterial effect and fungicidal activity.
    Pinosylvin monomethyl ether
  • HY-W017316R
    Terpinen-4-ol (Standard)
    Terpinen-4-ol (Standard) is the analytical standard of Terpinen-4-ol. This product is intended for research and analytical applications. Terpinen-4-ol (4-Carvomenthenol) is a naturally occurring monoterpene, and can be extracted from a variety of aromatic plants. Terpinen-4-ol is a potent bactericidal agent which possess antifungal , anti-inflammatory and antitumor properties as well, suggesting Terpinen-4-ol to be used for relevant research.
    Terpinen-4-ol (Standard)
  • HY-121982
    Cyclo(L-Phe-L-Val)
    		Inhibitor 99.88%
    Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). cyclo(L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions.
    Cyclo(L-Phe-L-Val)
  • HY-161091
    AM-2-19
    		Inhibitor
    AM-2-19 (SF001) is an ergosterol-extracting polyene antifungal that is discovered through modifications to the amphotericin B toxin by chemists.
    AM-2-19
  • HY-W016867
    4-Chlorosalicylic acid
    		Inhibitor 99.95%
    4-Chlorosalicylic acid is a pharmaceutical intermediate. Inhibits monophenolase and diphenolase activity with IC50s of 1.89 mM and 1.10 mM. Potent antimicrobial activity. Against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.
    4-Chlorosalicylic acid
  • HY-119784
    Eupenifeldin
    Eupenifeldin is pentacyclic bistropolone isolated from cultures of Eupenicillium brefeldianum ATCC 74184. Eupenifeldin is cytotoxic against the HCT-116 cell line. Eupenifeldin has the potential for the research of leukemia.
    Eupenifeldin
Cat. No. Product Name / Synonyms Application Reactivity