2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0672
    Pseudolaric Acid C
    		Inhibitor 99.59%
    Pseudolaric C is a diterpenoid isolated from the root bark of Pseudolarix amabilis, has antifungal activity.
    Pseudolaric Acid C
  • HY-N0216A
    Benzoic acid lithium
    		Inhibitor 99.63%
    Benzoic acid lithium is an aromatic alcohol found in many plants and is a common additive in food, beverages, cosmetics and other products. Benzoic acid lithium inhibits bacteria and fungi and acts as a preservative.
    Benzoic acid lithium
  • HY-N8420
    Thalifoline
    		Inhibitor 99.19%
    Thalifoline is an alkaloid and displays antifungal activity.
    Thalifoline
  • HY-N1997
    Pyromeconic acid
    		Inhibitor 99.01%
    Pyromeconic acid is an antifungal substance.
    Pyromeconic acid
  • HY-113430
    5-n-Heneicosylresorcinol
    		Inhibitor ≥98.0%
    5-n-Heneicosylresorcinol (5-Heneicosylresorcinol) is an active n-alkyl(enyl)resorcinols (AR) occurring in cereal products from Colombia. Antifungal activity.
    5-n-Heneicosylresorcinol
  • HY-125699
    Ochratoxin C
    		Inhibitor 99.35%
    Ochratoxin C is the ethyl ester analog of ochratoxin A, a mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant.
    Ochratoxin C
  • HY-172670
    Spore germination-IN-1
    		Inhibitor
    Spore germination-IN-1 (Compound 110) is an orally active spore germination inhibitor (IC50: 14 μM). Spore germination-IN-1 specifically inhibits the enzymatic activities of mature SleC and CspB on spores (Kd: 12 and 8 μM). Spore germination-IN-1 can be used in studies against C. difficile.
    Spore germination-IN-1
  • HY-17395S
    Terbinafine-d3 hydrochloride
    		Inhibitor 99.87%
    Terbinafine-d3 hydrochloride is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria.
    Terbinafine-d<sub>3</sub> hydrochloride
  • HY-W004282S
    Undecanoic acid-d21
    		Inhibitor 98.80%
    Undecanoic acid-d21 (Undecanoate-d21) is the deuterium labeled Undecanoic acid (HY-W004282). Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum.
    Undecanoic acid-d<sub>21</sub>
  • HY-106784
    Ajoene
    		Inhibitor ≥99.0%
    Ajoene, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities.
    Ajoene
  • HY-B2144J
    Chitosan (≥90% deacetylated,viscosity 650-700 mPa.s)
    		Inhibitor
    Chitosan (Deacetylated chitin) (≥90% deacetylated, viscosity 650-700 mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi. Chitosan (≥90% deacetylated, viscosity 650-700 mPa.s) can be used as a versatile biomaterial in drug delivery, tissue engineering, and wound healing.
    Chitosan (≥90% deacetylated,viscosity 650-700 mPa.s)
  • HY-119847
    Abafungin
    		Chemical 99.10%
    Abafungin, a antifungal agent, inhibitis the transmethylation at the C-24 position of the sterol side chain, catalyzed by the enzyme sterol-C-24-methyltransferase.
    Abafungin
  • HY-111912
    Tribenuron-methyl
    		Inhibitor ≥98.0%
    Tribenuron-methyl, a sulfonylurea herbicide agent, can be used as the fungicide agent. Tribenuron-methyl plays an important role in controlling the weeds and diseases in wheat field.
    Tribenuron-methyl
  • HY-N7996
    Matairesinoside
    		Inhibitor 99.88%
    Matairesinoside is a lignan with antibacterial and antioxidant activities. Matairesinoside also shows virus-cell fusion inhibitory activity.
    Matairesinoside
  • HY-138136
    Ticlatone
    		Inhibitor 99.02%
    Ticlatone is an antifungal that can be used for the research of mycoses.
    Ticlatone
  • HY-B0238R
    Amorolfine hydrochloride (Standard)
    		Inhibitor
    Amorolfine (hydrochloride) (Standard) is the analytical standard of Amorolfine (hydrochloride). This product is intended for research and analytical applications. Amorolfine (Ro 14-4767/002) hydrochloride is a potent anti-fungal agent. Amorolfine hydrochloride inhibits ergosterol biosynthesis. Amorolfine hydrochloride has the potential for the research of Neoscytalidium dimidiatum onychomycosis.
    Amorolfine hydrochloride (Standard)
  • HY-14273R
    Isavuconazole (Standard)
    		Inhibitor
    Isavuconazole (Standard) is the analytical standard of Isavuconazole. This product is intended for research and analytical applications. Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.
    Isavuconazole (Standard)
  • HY-100121
    Vibunazole
    		Inhibitor 99.91%
    Vibunazole (BAY-N-7133) is an antifungal azole agent. Vibunazole inhibits coccidioidostatic.
    Vibunazole
  • HY-B0421R
    Mycophenolic acid (Standard)
    		Inhibitor
    Mycophenolic acid (Standard) is the analytical standard of Mycophenolic acid. This product is intended for research and analytical applications. Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
    Mycophenolic acid (Standard)
  • HY-B0576
    Sulfacetamide sodium
    		Inhibitor 99.71%
    Sulfacetamide (Sulphacetamide) sodium is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide sodium has antifungal and antibacterial activities.
    Sulfacetamide sodium
Cat. No. Product Name / Synonyms Application Reactivity