2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14219
    Enactin Ⅴa
    		Inhibitor
    Enactin Va is found in the strain of Streptomyces roseoviridis. Enactin Va has only weak antifungal activity.
    Enactin Ⅴa
  • HY-N14605
    Chandrananimycin C
    		Inhibitor
    Chandrananimycin C has anti-mucor activity, as well as anti-tumor cell activity such as CCL HT29, MFXF 529L, MACL McF-7.
    Chandrananimycin C
  • HY-W748023
    Cryptosporiopsin A
    		Inhibitor
    Cryptosporiopsin A, a polyketide with antifungal activity, exhibits motility inhibitory and lytic activities against zoospores of the grapevine downy mildew pathogen Plasmopara viticola.
    Cryptosporiopsin A
  • HY-N14527
    Octacosamicin B
    		Inhibitor
    Octacosamicin B has the function of resisting bacterium, yeast, and filamentous fungus, but the function of resisting bacterium is weak.
    Octacosamicin B
  • HY-B0450AR
    Ciclopirox olamine (Standard)
    		Inhibitor
    Ciclopirox (olamine) (Standard) is the analytical standard of Ciclopirox (olamine). This product is intended for research and analytical applications. Ciclopirox olamine (Ciclopirox ethanolamine) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox olamine also has anticancer and anti-inflammatory effect.
    Ciclopirox olamine (Standard)
  • HY-N14856
    Verlamelin
    		Inhibitor
    Verlamelin is a depsipeptide antibiotic. Verlamelin has anti-fungal activity against plant pathogens.
    Verlamelin
  • HY-W715444
    Mucidin
    		Inhibitor
    Mucidin is an antifungal antibiotic that inhibits electron-transfer reactions in the cytochrome bc1 complex of the mitochondrial respiratory chain.
    Mucidin
  • HY-120921R
    Zoxamide (Standard)
    Zoxamide (Standard) is the analytical standard of Zoxamide. This product is intended for research and analytical applications. Zoxamide (RH-7281) is an oomycete fungicide. Zoxamide arrests nuclear division in Phytophthora capsici germlings and destroyed the microtubule cytoskeleton.
    Zoxamide (Standard)
  • HY-N13889
    Altiloxin A
    Altiloxin A, a fungal metabolite, is a drimane-type sesquiterpenoid. Altiloxin A shows phytotoxic activity on the lettuce seedlings.
    Altiloxin A
  • HY-N13994
    Clavamycin A
    		Inhibitor
    Clavamycin A has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase.
    Clavamycin A
  • HY-W019852R
    Flutriafol (Standard)
    		Inhibitor
    Flutriafol (Standard) is the analytical standard of Flutriafol. This product is intended for research and analytical applications. Flutriafol is a triazole fungicide with broad spectrum fungicidal activity.
    Flutriafol (Standard)
  • HY-W017445
    Homogentisic acid lactone
    		Inhibitor 98.32%
    Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity.
    Homogentisic acid lactone
  • HY-125606
    Amphocil
    		Inhibitor
    Amphocil is an equimolar mixture of Amphotericin B (HY-B0221) and cholesteryl sulphate with antifungal effects. Amphocil is promising for research of disseminated cryptococcosis.
    Amphocil
  • HY-N1320
    Sambutoxin
    Sambutoxin is a mycotoxin. Sambutoxin can be isolated from wheat culture of Fusarium sambucinum.
    Sambutoxin
  • HY-N14788
    Cephemimycin
    		Inhibitor
    Cephemimycin has weak antibacterial and antifungal activity.
    Cephemimycin
  • HY-135141
    Tetrahydroechinocandin B
    		Inhibitor
    Tetrahydroechinocandin B (L 687,901) is a potent antifungal agent. Tetrahydroechinocandin B inhibits 1,3-beta-D-glucan synthesis with an IC50 of 0.85 μg/mL.
    Tetrahydroechinocandin B
  • HY-N6051R
    (-)-Maackiain (Standard)
    		Inhibitor
    (-​)​-Maackiain (Standard) is the analytical standard of (-​)​-Maackiain. This product is intended for research and analytical applications. (-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active.
    (-)-Maackiain (Standard)
  • HY-N14040
    Crocacin B
    		Inhibitor
    Crocacin B has anti-yeast and filamentous fungal activity. Crocacin B can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin B can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum.
    Crocacin B
  • HY-165494
    Oudemansin A
    		Inhibitor
    Oudemansin A is an antibiotic. Oudemansin A acts on fungi to inhibit protein, RNA and DNA synthesis.
    Oudemansin A
  • HY-Y0055R
    Phenothiazine (Standard)
    		Inhibitor
    Phenothiazine (Standard) is the analytical standard of Phenothiazine. This product is intended for research and analytical applications. Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases.
    Phenothiazine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity