2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-D2430
    Chitosan-PEG-Cy3
    		Inhibitor
    Chitosan-PEG-Cy3 is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, Chitosan and polyethylene glycol (PEG). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Chitosan exhibits antimicrobial activity against various bacteria and fungi.
    Chitosan-PEG-Cy3
  • HY-10445
    Pramiconazole
    		Inhibitor
    Pramiconazole is a broad-spectrum antifungal agent with oral activity. Pramiconazole has a good affinity for 14α-demethylase. Pramiconazole can be used in the study of fungal infections in the local skin, hair, nails, oral cavity, and genital mucosa.
    Pramiconazole
  • HY-118065R
    Fenhexamid (Standard)
    		Inhibitor
    Fenhexamid (Standard) is the analytical standard of Fenhexamid. This product is intended for research and analytical applications. Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor. Fenhexamid shows fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea).
    Fenhexamid (Standard)
  • HY-N14583
    Glucoallosamidin A
    		Inhibitor
    Glucoallosamidin A is a glycoside antibiotic that can inhibit Chitinase activity. Glucoallosamidin A can inhibit Candida albicans ATCC 10231 chitinase with an IC50 of 3.4 μg/mL.
    Glucoallosamidin A
  • HY-N15097
    Dihydrocompactin
    		Inhibitor
    Dihydrocompactin, an antifungal metabolite, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMG-CoA reductase) from Penicillium citrinum.
    Dihydrocompactin
  • HY-138540R
    1-Dodecylimidazole (Standard)
    		Inhibitor
    1-Dodecylimidazole (Standard) is the analytical standard of 1-Dodecylimidazole. This product is intended for research and analytical applications. 1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity.
    1-Dodecylimidazole (Standard)
  • HY-N13912
    Anticapsin
    		Inhibitor
    Anticapsin is a glucosamine-6-phosphate synthase inhibitor with antifungal effects.
    Anticapsin
  • HY-14283R
    Luliconazole (Standard)
    		Inhibitor
    Luliconazole (Standard) is the analytical standard of Luliconazole. This product is intended for research and analytical applications. Luliconazole (NND 502) is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including dermatophytosis, tinea corporis, tinea pedis et al.
    Luliconazole (Standard)
  • HY-N7063S
    Nerol-d2
    		Inhibitor
    Nerol-d2 is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity.
    Nerol-d<sub>2</sub>
  • HY-168155
    Mps1-IN-9
    		Inhibitor
    Mps1-IN-9 (compound M-12) is an Mps1-targeted inhibitor discovered for broad-spectrum antifungal agents..
    Mps1-IN-9
  • HY-125694
    MFB-1041
    		Inhibitor
    MFB-1041 is an orally active antifungal agent, but exhibits poor oral absorption. MFB-1041 induces the binding of drug to serum albumin.
    MFB-1041
  • HY-N14426
    Concanamycin F
    		Inhibitor
    Concanamycin F has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase (Ki=0.02 nM), which is an important tool for biochemical research.
    Concanamycin F
  • HY-N15595
    Curvulol
    		Inhibitor
    Curvulol is an antimicrobial agent with a polyketide structure. Curvulol can be isolated from Taxus baccata ( Chaetosphaeronema achilleae). Curvulol has a significant cytotoxicity against L929 and KB-3-1 cells, and strongly inhibits Staphylococcus aureus biofilm formation with a MIC of 64 μg/mL.
    Curvulol
  • HY-169812
    Dihydrobiochanin A
    		Inhibitor
    Dihydrobiochanin A has antifungal activity. Dihydrobiochanin A is a flavonoid that can isolated from Swartzia polyphylla.
    Dihydrobiochanin A
  • HY-170378
    Laccase-IN-5
    		Inhibitor
    Laccase-IN-5 (Compound 2b) is the inhibitor for Laccase with an IC50 of 0.82 μM. Laccase-IN-5 increases the cell membrane permeability, limits the growth of hyphae, destorys the cell wall, and induces oxidative stress responses. Laccase-IN-5 exhibits antifungal activity against various plant pathogenic fungi and oomycetes, inhibits B. dothidea with an EC50 of 0.96 mg/L.
    Laccase-IN-5
  • HY-129585
    SM-4470
    		Inhibitor
    SM-4470 is an orally active antifungal compound. SM-4470 has inhibitory activity against yeast, Aspergillus, and dermatophytes in vitro.
    SM-4470
  • HY-124408R
    Mepronil (Standard)
    		Inhibitor
    Mepronil (Standard) is the analytical standard of Mepronil. This product is intended for research and analytical applications. Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection.
    Mepronil (Standard)
  • HY-N5202
    Aspochalasin A
    		Inhibitor
    Aspochalasin A has anti-bacterial and anti-fungal effects.
    Aspochalasin A
  • HY-N14547
    Crotocin
    		Inhibitor
    Crotocin has the fungal activity of anti-cryptococcus neoforme, candida albicans, Tinea trichoderma of brewer's yeast, and can be inactivated by blood.
    Crotocin
  • HY-N15186
    Gymnoascolide A
    Gymnoascolide A, identified as a fungal metabolite in M. filamentosa, demonstrates vasodilatory effects. At a concentration of 1 µM, it effectively inhibits contractions induced by calcium in isolated rat aortic rings.
    Gymnoascolide A
Cat. No. Product Name / Synonyms Application Reactivity