2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-170885
    Group II intron-IN-1
    		Inhibitor
    Group II intron-IN-1 (Compound 1) is an inhibitor of fungal Group II introns, with an IC50 of 3 μM. Group II intron-IN-1 can be used for research on infections caused by fungi such as Candida.
    Group II intron-IN-1
  • HY-161049
    Antifungal agent 89
    		Inhibitor
    Antifungal agent 89 (compound 28) is a antifungal agent against Cryptococcus neoformans with minimum inhibitory concentration value ranging from 0.8 to 52.17 μM.
    Antifungal agent 89
  • HY-N14220
    Epoformin
    		Inhibitor
    Epoformin, is a fungal cyclohexene epoxide that can be isolated from Diplodia quercivora. Epoformin is an antibiotic and exhibits weak inhibitory activity against rye seedling sheath growth. Epoformin exhibits antifungal activity, inhibits Phytophthora cinnamomi and Phytophthora plurivora.
    Epoformin
  • HY-40354AR
    Tofacitinib citrate (Standard)
    		Inhibitor
    Tofacitinib (citrate) (Standard) is the analytical standard of Tofacitinib (citrate). This product is intended for research and analytical applications. Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.
    Tofacitinib citrate (Standard)
  • HY-N14155
    Epelmycin A
    		Inhibitor
    Epelmycin A has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.
    Epelmycin A
  • HY-161457
    (Gly0.8Nap0.2)20
    		Inhibitor
    (Gly0.8Nap0.2)20 is a compound that dual targets fungal membranes and DNA. (Gly0.8Nap0.2)20 has antibacterial activity.
    (Gly0.8Nap0.2)20
  • HY-173342
    Neocryptolepine-Cl
    		Inhibitor
    Neocryptolepine-Cl (compound Z24) is an inhibitor of Bcthi4 and exhibits excellent antifungal activity against B. cinerea with EC50 value of 0.56 μg/mL.
    Neocryptolepine-Cl
  • HY-N12497
    Moracin B
    		Inhibitor
    Moracin B is a phytoalexin with antifungal activity. Moracin B can be isolated from the cortex and phloem tissues of mulberry (Morus alba Linne) infected with Fusarium solani f. sp. mori. Moracin B can be used to study plant disease resistance mechanisms against microbial infections, particularly showing potential application value in the field of plant disease control.
    Moracin B
  • HY-174353S
    CYP51-IN-23-d3
    		Inhibitor
    CYP51-IN-23-d3 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum . CYP51-IN-23-d3 can prevent fungal phase transformation and biofilm formation. CYP51-IN-23-d3 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-23-d3 can be used for the study of invasive fungal infections (IFIs).
    CYP51-IN-23-d3
  • HY-B0851S
    Triadimenol-d4
    Triadimenol-d4 is the deuterium labeled Triadimenol. Triadimenol is a triazole fungicide and has been widely used in agriculture. Triadimenol has certain toxicity to animals.
    Triadimenol-d<sub>4</sub>
  • HY-138194
    Destomycin B
    		Inhibitor
    Destomycin B (A-16316-C) is an antibiotic, and is active against fungi. Destomycin B also has anthelmintic activity.
    Destomycin B
  • HY-118451
    Lanomycin
    		Inhibitor
    Lanomycin is an antifungal compound with activity against Candida and dermatophytes.
    Lanomycin
  • HY-N13025
    8-Acetylverrucarin L
    		Inhibitor
    8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candida albicans and Geotrichum candidum.
    8-Acetylverrucarin L
  • HY-B2048R
    Pencycuron (Standard)
    		Inhibitor
    Pencycuron (Standard) is the analytical standard of Pencycuron. This product is intended for research and analytical applications. Pencycuron is a benzoylurea fungicide. Pencycuron kills fungi by inhibiting the synthesis of fungal cell walls.Pencycuron can be used in research on the control of fungal diseases on crops, such as sheath blight, powdery mildew and late blight.
    Pencycuron (Standard)
  • HY-N13951
    Aranochlor A
    		Inhibitor
    Aranochlor A is an antibiotic found in Pseudoarachniotus roseus (HIL Y-30499). Aranochlor A exhibits antibacterial and antifungal activities.
    Aranochlor A
  • HY-N12675
    Phoslactomycin F
    		Inhibitor
    Phoslactomycin F has weak effect against Gram-positive bacteria, but has strong effect against fungi.
    Phoslactomycin F
  • HY-N13890
    Arginomycin
    		Inhibitor
    Arginomycin is a nucleoside antibiotic that inhibits the growth of Gram-positive bacteria and fungi in vitro.
    Arginomycin
  • HY-W286805
    Perinaphthenone
    		Inhibitor
    Perinaphthenone has antifungal activity, with IC50s of 36.2 μM (at day 3), 13.3 μM (at day 3), and 39.0 μM (at 60 h) for Botrytis spp., Fusarium spp. and Botryodiplodia spp., respectively.
    Perinaphthenone
  • HY-N14575
    Pyrrolomycin B
    		Inhibitor
    Pyrrolomycin B is a pyrrole antibiotic. Pyrrolomycin B has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-individual fungi activity.
    Pyrrolomycin B
  • HY-17373S2
    Posaconazole-d3
    		Inhibitor
    Posaconazole-d3 (SCH 56592-d3) is deuterium labeled Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
    Posaconazole-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity