2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W167979
    3-Amino-1,2,4-triazin-5(2H)-one
    		Inhibitor
    3-Amino-1,2,4-triazin-5(2H)-one is an organic compound belonging to the triazine family. 3-Amino-1,2, 4-Triazin-5 (2H)-one and its derivatives may have a variety of biological activities, such as antibacterial, antifungal, antiviral, or antitumor but the specific activity depends on its chemical structure and functional groups. 3-Amino-1,2, 4-Triazin-5 (2H)-one is a lead compound with a wide range of applications.
    3-Amino-1,2,4-triazin-5(2H)-one
  • HY-N0363AR
    (+)-Columbianetin acetate (Standard)
    (+)-Columbianetin acetate (Standard) is the analytical standard of (+)-Columbianetin acetate. This product is intended for research and analytical applications. (S)-Columbianetin acetate is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity.
    (+)-Columbianetin acetate (Standard)
  • HY-N14016
    Chaetiacandin
    		Inhibitor
    Chaetiacandin inhibits Candida albicans.
    Chaetiacandin
  • HY-N15343
    Albiducin A
    		Inhibitor
    Albiducin A is an antibiotic found in Hymenoscyphus albidus, exhibiting antibacterial and anticancer activities. The MIC range of Albiducin A against bacteria and fungi is 16.7-66.7 mg/mL. Its IC50 values for mouse fibroblast cell line (L929) and human cervical carcinoma cell line (KB3-1) are 6.1 and 2.7 μg/mL, respectively. Albiducin A holds promise for research in the fields of infection and cancer diseases.
    Albiducin A
  • HY-121766
    Iprovalicarb
    		Inhibitor
    Iprovalicarb (Fencaramid; SZX-0722) is a fungicide that can be used for the study of fungal diseases in the wine sector.
    Iprovalicarb
  • HY-129900
    (-)-Luteoskyrin
    		Inhibitor
    (-)-Luteoskyrin has a wide range of antibacterial activity, such as against malaria (with an IC50 of 0.51 μg/mL), tuberculosis (MIC of 6.25 μg/mL), and it also shows antibacterial effects (with MIC for Gram-positive bacteria ranging from 0.39 to 1.56 μg/mL, and for Gram-negative bacteria from 3.13 to 12.50 μg/mL), as well as antifungal activity (with MIC against plant pathogens ranging from 3.13 to 50μg/mL). (-)-Luteoskyrin exhibits cytotoxicity against NCI-H187 cells, with an IC50 range of 0.16–17.99 μg/mL.
    (-)-Luteoskyrin
  • HY-W514721
    D13
    		Inhibitor
    D13, an Acylhydrazones derivative, possesses antifungal activity. D13 is effective against murine sporotrichosis.
    D13
  • HY-W714076R
    Ametoctradin (Standard)
    		Inhibitor
    Ametoctradin (Standard) is the analytical standard of Ametoctradin. This product is intended for research and analytical applications. Ametoctradin is a potent Qo site inhibitor of bc1 complex in mitochondrial respiration. Ametoctradin is a highly selective and effective Oomycete-specific fungicide that can be used against late blight and downy mildews.
    Ametoctradin (Standard)
  • HY-116568R
    Prothioconazole (Standard)
    		Inhibitor
    Prothioconazole (Standard) is the analytical standard of Prothioconazole. This product is intended for research and analytical applications. Prothioconazole is a triazolinthione fungicide. Prothioconazole is a CYP51 inhibitor.
    Prothioconazole (Standard)
  • HY-N14442
    Haliangicin B
    		Inhibitor
    Haliangicin B has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
    Haliangicin B
  • HY-B0572R
    Zinc Pyrithione (Standard)
    		Inhibitor
    Zinc Pyrithione (Standard) is the analytical standard of Zinc Pyrithione. This product is intended for research and analytical applications. Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump. Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis.
    Zinc Pyrithione (Standard)
  • HY-N14159
    Epelmycin E
    		Inhibitor
    Epelmycin E has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.
    Epelmycin E
  • HY-N12267A
    Terrestribisamide
    		Inhibitor
    Terrestribisamide ((E)-N,N′-Diferuloylputrescine) can be isolated from dried fruits of Tribulus terrestris. Terrestribisamide has antibacterial, antifungal, antioxidant, anticancer effects.
    Terrestribisamide
  • HY-N14990
    Pneumocandin C0
    		Inhibitor
    Pneumocandin C0 is the isomer of Pneumocandin B0 (HY-17578) with antifungal activity, which is found by carrying out fermentations of Glarea lozoyensis at a high residual fructose concentration.
    Pneumocandin C0
  • HY-N5161
    Arborcandin B
    		Inhibitor
    Arborcandin B is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin B exhibits IC50 values of 0.30 μg/mL and 0.025 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin B has an MIC of 2-4 μg/mL against the genus Candida.
    Arborcandin B
  • HY-B0854R
    Mancozeb (Standard)
    		Inhibitor
    Mancozeb (Standard) is the analytical standard of Mancozeb. This product is intended for research and analytical applications. Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells.
    Mancozeb (Standard)
  • HY-156195
    BHBM
    		Inhibitor
    BHBM (compound 1) is an aromatic acylhydrazone antifungal agent with high bactericidal activity against Cryptococcus neoformans.
    BHBM
  • HY-163634
    YZK-C22
    		Inhibitor
    YZK-C22, containing a 1,2,3-thiadiazol-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole skeleton, is a fungicide lead compound with broad-spectrum fungicidal activity.
    YZK-C22
  • HY-N14817
    Neocopiamycin B
    		Inhibitor
    Neocopiamycin B is found in the strain of Str. hygroscopicus var. crystallogenes. Neocopiamycin B has antifungal activity.
    Neocopiamycin B
  • HY-W715372
    Pyraoxystrobin
    		Inhibitor
    Pyraoxystrobin is a QoI fungicide, with an EC50 of 0.0094 μg/mL for M. oryzae isolates. Pyraoxystrobin can be used for the research of M. oryzae in rice fields.
    Pyraoxystrobin
Cat. No. Product Name / Synonyms Application Reactivity